Analysis of thermo-sensitive nociceptor expression and mechanism by using dentin-pulp complex culture system.
| Project/Area Number |
19791404
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Conservative dentistry
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| Research Institution | Kagoshima University |
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Principal Investigator |
TATSUYAMA Shoko Kagoshima University, 医学部・歯学部附属病院, 助教 (70347095)
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| Project Period (FY) |
2007 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥5,010,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥810,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2007: ¥1,500,000 (Direct Cost: ¥1,500,000)
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| Keywords | 象牙芽歯髄複合体 / 温度感受性受容体 / 象牙芽細胞 / 歯髄細胞 / VR-1 / TRPV8 / 温度感受性イオンチャンネル / 象牙質歯髄複合体 / 象牙知覚過敏症 / 温感受性イオンチャンネル / 免疫染色法 / 象牙質知覚過敏症 |
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| Research Abstract |
In this study, we confirmed the expression of the transient receptor potential melastatin-8 (TRPM8) in human dental pulp cells and in mouse odontoblasts. Using rat dental pulp slice culture as a dentin-pulp complex models we further revealed TRPM8 expression in rat odontoblasts. Our results indicated that odontoblasts could directly respond to noxious stimuli, example as cold condition, and transduce the signal to the nearby nerves, accordingly odontblasts may be involved in dentin hypersensitivity.
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Report
(4 results)
Research Products
(2 results)
