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Regeneration of dental pulp by transplantation of endothelial progenitor cells from tooth, bone marrow, artery, and adipose tissue.

Research Project

Project/Area Number 19791418
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Conservative dentistry
Research InstitutionNational Institute for Longevity Sciences,NCGG

Principal Investigator

庵原 耕一郎  National Institute for Longevity Sciences,NCGG, 口腔疾患研究部, 特任研究員 (60435865)

Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥3,780,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥480,000)
Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2007: ¥1,700,000 (Direct Cost: ¥1,700,000)
Keywords歯内療法学 / SP細胞 / 歯髄 / 大動脈 / 骨髄 / 脂肪 / ヤイクロアレイ / 歯髄幹細胞 / 大動派 / マイクロアレイ
Research Abstract

創傷治癒部位においては、骨髄より湧出し全身血管を循環している単核球あるいはangioblastまたは、局所動静脈壁の組織幹細胞が血管新生や免疫反応に関与することが示唆されている。本研究は歯髄傍血管に存在する幹・前駆細胞(CD34^+ ; CD31^- ; CD146^-SP細胞)の発現遺伝子を全身組織あるいは骨髄由来のものと網羅的に比較した。よって、深い齲蝕、歯髄炎、あるいは抜髄後の歯髄再生治療において、有用な細胞源を確保する手がかりを与えるものと期待される。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (20 results)

All 2008 2007

All Journal Article (4 results) (of which Peer Reviewed: 2 results) Presentation (14 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] A novel stem cell source for vasculogenesis in ischemia: subfraction of side population cells from dental pulp2008

    • Author(s)
      Iohara K, Zheng L, Wake H, Ito M, Nabekura J, Wakita H, Nakamura H, Into T, Matsushita K, Nakashima M.
    • Journal Title

      Stem Cells 26

      Pages: 2408-2418

    • Related Report
      2008 Final Research Report
  • [Journal Article] ラット歯髄創傷治癒過程におけるMMP-3の機能解析2008

    • Author(s)
      天野一晴, 中島美砂子, 鄭力, 庵原耕一郎, 松井寛敬, 山崎雅弘, 松下健二, 中村洋
    • Journal Title

      日本歯科保存学雑誌 51

      Pages: 602-613

    • NAID

      110007026966

    • Related Report
      2008 Final Research Report
  • [Journal Article] A novel stem cell source for vasculogenesis in ischemia : subfraction of side population cells from dental pulp2008

    • Author(s)
      Iohara K, Zheng L, Wake H, Ito M, Nabekura J, Wakita H, Nakamura H, Into T, Matsushita K, Nakashima M.
    • Journal Title

      Stem Cells 26

      Pages: 2408-2418

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ラット歯髄創傷治癒過程におけるMMP-3の機能解析2008

    • Author(s)
      天野一晴、中島美砂子、鄭力、庵原耕一郎、松井寛敬、山崎雅弘、松下健二、中村洋
    • Journal Title

      日本歯科保存学雑誌 51

      Pages: 602-613

    • NAID

      110007026966

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] Enhanced wound healing by matrix metalloproteinase-3 after dental pulp amputation2008

    • Author(s)
      Amano K, Nakashima M, Zheng L, Iohara K, Matsui H, Yamasaki M, Matsushita K, Nakamura H.
    • Organizer
      Japanese Association for Dental Researc
    • Place of Presentation
      Nagya
    • Year and Date
      2008-11-30
    • Related Report
      2008 Final Research Report
  • [Presentation] Enhanced wound healing by matrix metalloproteinase-3 after dental pulpamputation2008

    • Author(s)
      Amano K, Nakashima M, Zheng L, Iohara K, Matsui H, Yamasaki M. Matsushita K, Nakamura H.
    • Organizer
      Japanese Association for Dental Research
    • Place of Presentation
      Nagya
    • Year and Date
      2008-11-30
    • Related Report
      2008 Annual Research Report
  • [Presentation] 乳歯由来歯髄細胞は血管新生・神経再生を促進する2008

    • Author(s)
      庵原耕一郎, 杉山昌彦, 中村さやか, 山田陽一, 上田実, 松下健二, 中村洋, 中島美砂子
    • Organizer
      日本歯科保存学会
    • Place of Presentation
      富山
    • Year and Date
      2008-11-06
    • Related Report
      2008 Final Research Report
  • [Presentation] 乳歯由来歯髄細胞は血管新生・神経再生を促進する2008

    • Author(s)
      庵原耕一郎、杉山昌彦、中村さやか、山田陽一、上田実、松下健二、中村洋、中島美砂子
    • Organizer
      第129回日本歯科保存学会
    • Place of Presentation
      富山
    • Year and Date
      2008-11-06
    • Related Report
      2008 Annual Research Report
  • [Presentation] 歯髄幹細胞を用いた血管・神経の再生医療2008

    • Author(s)
      中島美砂子, 庵原耕一郎
    • Organizer
      第53回(社)日本口腔外科学会総会
    • Place of Presentation
      徳島
    • Year and Date
      2008-10-20
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] Pulp Regeneration2008

    • Author(s)
      Nakashima M, Iohara K.
    • Organizer
      th International Conference on Bone Morphogenetic Proteins
    • Place of Presentation
      Lake Tahoe, California
    • Year and Date
      2008-07-12
    • Related Report
      2008 Final Research Report
  • [Presentation] Pulp Regeneration2008

    • Author(s)
      Nakashima M, Iohara K.
    • Organizer
      7^<th> International Conference on Bone Morphogenetic Proteins
    • Place of Presentation
      Lake Tahoe, California
    • Year and Date
      2008-07-12
    • Related Report
      2008 Annual Research Report
  • [Presentation] 歯髄CD31陰性SP細胞の歯髄および脳組織における神経・血管再生に対する効果の検討2008

    • Author(s)
      杉山昌彦, 庵原耕一郎, 脇田英明, 服部宇, 上田実, 中島美砂子
    • Organizer
      日本歯科保存学会
    • Place of Presentation
      新潟
    • Year and Date
      2008-06-06
    • Related Report
      2008 Final Research Report
  • [Presentation] 歯髄CD31陰性SP細胞の歯髄および脳組織における神経・血管再生に対する効果の検討2008

    • Author(s)
      杉山昌彦、庵原耕一郎、脇田英明、服部宇、上田実、中島美砂子
    • Organizer
      第128回日本歯科保存学会
    • Place of Presentation
      新潟
    • Year and Date
      2008-06-06
    • Related Report
      2008 Annual Research Report
  • [Presentation] 歯髄幹細胞を用いた象牙質・歯髄再生-歯の延命化を目指して2008

    • Author(s)
      中島美砂子, 庵原耕一郎
    • Organizer
      日本歯科放射線学会第49回学術大会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-05-17
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] 高い血管新生能を有する歯髄CD31陰性SP細胞による歯髄再生2008

    • Author(s)
      庵原耕一郎, 鄭力, 和気弘明, 伊藤正孝, 鍋倉淳一, 脇田英明, 中村洋, 引頭毅, 松下健二, 中島美砂子
    • Organizer
      日本再生医療学会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-03-12
    • Related Report
      2008 Final Research Report 2007 Annual Research Report
  • [Presentation] A Potential New Cell Source for Vasculogenesis in Ischemia, CD31-;CD146- Side Population Cells from Dental Pulp2007

    • Author(s)
      Nakashima M, Iohara K, Zheng L, Wake H, Ito M, Wakita H, Nabekura J, Nakamura H, Into T, Matsushita K
    • Organizer
      The American Society for Cell Biology 47th Annual Meeting
    • Place of Presentation
      Washington, DC, USA
    • Year and Date
      2007-12-04
    • Related Report
      2008 Final Research Report
  • [Presentation] A Potential New Cell Source for Vasculogenesis in Ischemia,CD31-;CD146- Side Population Cells from Dental Pulp2007

    • Author(s)
      Nakashima M, Iohara K, Zheng L, Wake H, Ito M, Wakita H, Nabekura J, Nakamura H, Into T, Matsushita K
    • Organizer
      The American Society for Cell Biology 47th Annual Meeting
    • Place of Presentation
      Washington,DC,USA
    • Year and Date
      2007-12-04
    • Related Report
      2007 Annual Research Report
  • [Presentation] 高い血管新生能を有する歯髄CD31陰性SP細胞を用いた歯髄再生2007

    • Author(s)
      庵原耕一郎, 中村洋, 松下健二, 中島美砂子
    • Organizer
      日本歯科保存学会
    • Place of Presentation
      岡山
    • Year and Date
      2007-11-08
    • Related Report
      2008 Final Research Report 2007 Annual Research Report
  • [Patent(Industrial Property Rights)] 管充填材及び歯組織再生方法2008

    • Inventor(s)
      中島美砂子, 庵原耕一郎
    • Industrial Property Rights Holder
      ヒューマンサイエンス財団
    • Filing Date
      2008-03-12
    • Related Report
      2008 Final Research Report
  • [Patent(Industrial Property Rights)] 根管充填材及び歯組織再生方法2008

    • Inventor(s)
      中島美砂子, 庵原耕一郎
    • Industrial Property Rights Holder
      ヒューマンサイエンス財団
    • Industrial Property Number
      2008-063391
    • Filing Date
      2008-03-12
    • Related Report
      2008 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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