Synthesis of a water-soluble nanocarbon and its biodistribution

• Project/Area Number: 19791419
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: 補綴理工系歯学
• Research Institution: Hokkaido University
• Principal Investigator: ABE Shigeaki Hokkaido University, 大学院歯学研究科, 助教 (40374566)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥3,520,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥420,000); Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2007: ¥1,700,000 (Direct Cost: ¥1,700,000)
• Keywords: 生体適合性 / 体内動態 / カーボンナノチューブ / ・マイクロ / ナノ粒子 / 歯科用材料・歯科理工学

Research Abstract

本研究では、フラーレンやカーボンナノチューブ(以下、CNT)など炭素系ナノ微粒子の生体適合性検討の為、上記素材の親水化、体内での循環・滞留・排泄(体内動態)の可視化・追跡を試みた。化学的表面修飾により、生体へと投与可能なCNT分散液を作成し、この分散液をマウスへと投与、経過観察を行った。電子顕微鏡観察から各臓器へのCNTの到達が確認された。また体内動態可視化法の検討の為、走査型蛍光X線分析顕微鏡、核磁気共鳴撮像(MRI)法などを用いて無機粒子の体内動態の観測に成功した。

Research Products

• [Journal Article] Time-dependence and visualization of TiO2 and Pt particle biodistribution in mice (2009)
  • Author(s): S. Abe, C. Koyama, M. Uo, T. Akasaka, Y. Kuboki and F. Watari
  • Journal Title: J. Nanoscience Nanotechnology 9 Pages: 4988-4991
  • Peer Reviewed
• [Journal Article] A DFT and MD study on the interaction of carbon nano-materials with metal ions (2009)
  • Author(s): S. Abe, F. Watari, T. Takada and H. Tachikawa
  • Journal Title: Molecular Crystals and Liquid Crystals 505 Pages: 51-58
  • Peer Reviewed
• [Journal Article] Internal distribution of several inorganic microparticles in mice (2009)
  • Author(s): S. Abe, C. Koyama, T. Akasaka, M. Uo, Y. Kuboki, and F. Watari
  • Journal Title: Internal distribution of several inorganic microparticles in mice 396-398 Pages: 539-542
  • Peer Reviewed
• [Journal Article] Development of a multiwalled carbon nanotube coated collagen dish (2009)
  • Author(s): M. Terada, S. Abe, T. Akasaka, M. Uo, Y. Kitagawa, and F. Watari
  • Journal Title: Dental Material J. 28 Pages: 82-88
  • NAID: 110007041975
  • Peer Reviewed
• [Journal Article] Maturation of osteoblast-like SaoS2 induced by carbon nanotubes (2009)
  • Author(s): X. Li, H. Gao, M. Uo, Y. Sato, T. Akasaka, S. Abe, Q. Feng, F. Cui, and F. Watari
  • Journal Title: Biomedical Materials 4 Pages: 15005-15012
  • Peer Reviewed
• [Journal Article] Visualization of invasion into the body and internal diffusion of nanoparticles (2009)
  • Author(s): F. Watari, S. Abe, I..Rosca, A. Yokoyama, M. Uo, T. Akasaka, N..Takashi, Y. Totsuka, E..Hirata, M. Matsuoka, K..Ishikawa, S..Itoh and Y..Yawaka
  • Journal Title: Key Engineering Materials 396-398 Pages: 569-572
  • Peer Reviewed
• [Journal Article] Material nanosizing effect on living organisms : non-specific, biointeractive, physical size effects (2009)
  • Author(s): F. Watari, N. Takashi, A. Yokoyama, M. Uo, T. Akasaka, Y. Sato, S. Abe, Y. Totsuka, K Tohji
  • Journal Title: J. Royal Society Interface 6
  • Peer Reviewed
• [Journal Article] Internal distribution of several inorganic microparticles in mice (2009)
  • Author(s): S. Abe, C. Koyama, T. Akasaka, M. Uo, Y. Kuboki, and F. Watari
  • Journal Title: Key Engineering Materials 396-398 Pages: 539-542
  • Peer Reviewed
• [Journal Article] Visualization of invasion into the body and internal diffusion of nanoparticles (2009)
  • Author(s): F. Watari, S. Abe, I..Rosca, A. Yokoyama, M. Uo, T. Akasaka, N..Takashi, Y. Totsuka, E.. Hirata, M. Matsuoka, K.. Ishikawa, S.. Itoh and Y.. Yawaka
  • Journal Title: Key Engineering Materials 396-398 Pages: 569-572
  • Peer Reviewed
• [Journal Article] Time-dependence and visualization of TiO_2 and Pt particle hiodistribution in mice (2009)
  • Author(s): S. Abe, C. Koyama, M. Uo, T. Akasaka, Y. Kuboki and F. Watari
  • Journal Title: J. Nanoscience Nanotechnology 9 Pages: 4988-4991
  • Peer Reviewed
• [Journal Article] Ab-initio calculations on the structures and electronic states of dimethylsulfide-water clusters (2008)
  • Author(s): S. Abe, T. Fukuzumi, and H. Tachikawa
  • Journal Title: Synth. React. Inorg. Met.-Org. Nano-Metal Chem 38 Pages: 105-110
  • Peer Reviewed
• [Journal Article] H. Nakagawa, M. Ohira, S. Hayashi, S. Abe, S. Saito, N. Nagahori, K. Monde, Y. Shinohara, N. Fujitani, H. Kondo, S. Akiyama, A. Nakagawara, and S. Nishimura (2008)
  • Author(s): H. Nakagawa, M. Ohira, S. Hayashi, S. Abe, S. Saito, N. Nagahori, K. Monde, Y. Shinohara, N. Fujitani, H. Kondo, S. Akiyama, A. Nakagawara, and S. Nishimura
  • Journal Title: Cancer Letters 270 Pages: 296-301
  • Peer Reviewed
• [Journal Article] Behavior of in vitro, in vivo and internal motion of micro/nano particles of titanium, titanium oxides and others (2008)
  • Author(s): F. Watari, S. Abe, C. Koyama, A. Yokoyama, T. Akasaka, M. Uo, M. Matsuoka, Y. Totsuka, M. Esaki, M. Morita, and T. Yonezawa
  • Journal Title: J. Ceram. Soc. Jpn 116 Pages: 1-5
  • NAID: 110006614230
  • Peer Reviewed
• [Journal Article] XAFS analysis of Ti and Ni dissolution from pure Ti, Ni-Ti alloy, and SUS304 in soft tissues (2008)
  • Author(s): M. Uo, K. Asakura, K. Tamura, Y. Totsuka, S. Abe, T. Akasaka, and F. Watari
  • Journal Title: Chemistry Letters 37 Pages: 958-959
  • NAID: 10024282428
  • Peer Reviewed
• [Journal Article] Internal diffusion of micro/nanoparticles inside body (2008)
  • Author(s): F. Watari, S. Abe, K. Tamura, M. Uo, A. Yokoyama, and Y. Totsuka
  • Journal Title: Key Engineeing Materials 361-363 Pages: 95-98
  • Peer Reviewed
• [Journal Article] Alterations in the glycoform of cisplatin-resistant human carcinom a cells are caused by defects in the endoplasmic reticulum-associated degradation system (2008)
  • Author(s): H. Nakagawa, M. Ohira, S. Hayashi, S. Abe, S. Saito, N. Nagahori, K. Monde, Y. Shinohara, N. Fujitani, H. Kondo, S. Akiyama, A. Nakagawara, and S. Nishimura
  • Journal Title: Cancer Letters 270 Pages: 296-301
  • Peer Reviewed
• [Journal Article] Internal diffusion of micro/nanoparticles inside body (2008)
  • Author(s): F. Watari, S. Abe, K. Tamura, M. Uo, A. Yokoyama, and Y Totsuka
  • Journal Title: Key Engineering Materials 361-363 Pages: 95-98
  • Peer Reviewed
• [Journal Article] Ab-initio calculations on the structures and electronic states of dimethylsulfide-water clusters (2008)
  • Author(s): Shigeaki Abe, Takahiro Fukuzumi, and Hiroto Tachi kawa
  • Journal Title: Synth. React. Inorg. Met.-Org. Nano-Metal Chem 38 Pages: 105-110
  • Peer Reviewed
• [Journal Article] Reaction dynamics following electron capture of chlorofluorocarbon adsorbed on water cluster: A direct density functional theory molecular dynamics study (2007)
  • Author(s): H. Tachikawa and S. Abe
  • Journal Title: J. Chem. Phys 126 Pages: 194310-194319
  • Peer Reviewed
• [Journal Article] Reaction dynamics following electron capture of chlorofluor ocarbon adsorbed on water cluster: A direct density functional theory molecular dynamics study (2007)
  • Author(s): Hiroto Tachikawa and Shigeaki Abe
  • Journal Title: J. Chem. Phys 126 Pages: 194310-194319
  • Peer Reviewed
• [Journal Article] Biodistribution imaging of magnetic nanoparticles in mice compared with X-ray scanning analytical microscopy and Magnetic Resonance imaging
  • Author(s): S. Abe, I. Kida, M. Esaki, T. Akasaka, M. Uo, Y. Sato, B. Jeyadevan, Y. Kuboki, M. Morita, K.Tohji, and F. Watari
  • Journal Title: Bio-Medical Materials and Engineering in press
  • Peer Reviewed
• [Journal Article] In vivo internal diffusion of several inorganic microparticles through an oral administration
  • Author(s): S. Abe, C. Koyama, M. Esaki, T. Akasaka, M. Uo, Y. Kuboki, M. Morita, and F. Watari
  • Journal Title: Bio-Medical Materials and Engineering in press
  • Peer Reviewed
• [Journal Article] Multiwalled carbon nanotube coating on titanium
  • Author(s): M. Terada, S. Abe, T. Akasaka, M. Uo, Y. Kitagawa, and F. Watari
  • Journal Title: Bio-Medical Materials and Engineering in press
  • NAID: 120001415110
  • Peer Reviewed
• [Journal Article] Adhesion of human osteoblast-like cells (Saos-2) to carbon nanotube sheets
  • Author(s): T. Akasaka, A. Yokoyama, M. Matsuoka, T. Hashimoto, S. Abe, M. Uo and F. Watari
  • Journal Title: Bio-Medical Materials and Engineering in press
  • NAID: 120003878531
  • Peer Reviewed
• [Journal Article] In vivo internal diffusion of several inorganic microparticles through an oral administration
  • Author(s): S. Abe, C. Koyama, M. Esaki, T. Akasaka, M. Uo, Y Kubold, M. Morita, and F. Watari
  • Journal Title: Bio-Medical Materials and Engineering (in press)
  • Peer Reviewed
• [Journal Article] Biodistribution imaging of magnetic nanoparticles in mice compared with X-ray scanning analytical microscopy and Magnetic Resonance imaging
  • Author(s): S. Abe, I. Kida, M. Esaki, T. Akasaka, M. Uo, Y Sato, B. Jeyadevan, Y. Kuboki, M. Morita, K.Tohji, and F. Watari
  • Journal Title: Bio-Medical Materials and Engineering (in press)
  • Peer Reviewed
• [Journal Article] Multiwalled carbon nanotube coating on titanium
  • Author(s): M. Terada, S. Abe, T. Akasaka, M. Uo, Y. Kitagawa, and F. Watari
  • Journal Title: Bio-Medical Materials and Engineering (in press)
  • NAID: 120001415110
  • Peer Reviewed
• [Journal Article] Adhesion of human osteoblast-like cells(Saos-2) to carbon nanotube sheets
  • Author(s): T. Akasaka, A. Yokoyama, M. Matsuoka, T. Hashimoto, S. Abe, M. Uo and F. Watari
  • Journal Title: Bio-Medical Materials and Engineering (in press)
  • NAID: 120003878531
  • Peer Reviewed
• [Presentation] A direct study on graphene-water interaction system (2009)
  • Author(s): S. Abe, Y. Nagoya, F. Watari and H. Tachikawa
  • Organizer: 5th International Conference on Molecular Electronics and Bioelectronics
  • Place of Presentation: Miyazaki
  • Year and Date: 2009-03-17
• [Presentation] A direct study on graphene-water interaction system (2009)
  • Author(s): S. Abe, Y. Nagoya, F. Watari and H. Tachikawa
  • Organizer: 5^<th> International Conference on Molecular Electronics and Bioelectronics
  • Place of Presentation: Miyazaki、Miyazaki International Conference Hall
  • Year and Date: 2009-03-17
• [Presentation] 成層圏での氷上にトラップされたフロン化合物の光分解メカニズム (2009)
  • Author(s): 阿部薫明、亘理文夫、田地川浩人
  • Organizer: 北海道支部2009年冬季研究発表会
  • Place of Presentation: 札幌
  • Year and Date: 2009-02-03
• [Presentation] 成層圏での氷上にトラップされたフロン化合物の光分解メカニズム (2009)
  • Author(s): 阿部薫明、亘理文夫、田地川浩人
  • Organizer: 北海道支部2009年冬季研究発表会
  • Place of Presentation: 札幌市、北海道大学
  • Year and Date: 2009-02-03
• [Presentation] 人工酵素モデルを用いた石灰化反応の制御 (2009)
  • Author(s): 林大輔、阿部薫明、石田智毅、大和谷恵実、赤坂司、宇尾基弘、亘理文夫、高田知哉
  • Organizer: 第21回代用臓器・再生医学研究会
  • Place of Presentation: 札幌
  • Year and Date: 2009-01-31
• [Presentation] 人工酵素モデルを用いた石灰化反応の制御 (2009)
  • Author(s): 林大輔、阿部薫明、石田智毅、大和谷恵実、赤坂司、宇尾基弘、亘理文夫、高田知哉
  • Organizer: 第21回代用臓器・再生医学研究会
  • Place of Presentation: 札幌市、札幌医科大学
  • Year and Date: 2009-01-31
• [Presentation] A DFT and MD study on the evaporation dinamics of water molecules on carbon nano-materials (2008)
  • Author(s): S. Abe, Y. Nagoya, F. Watari and H. Tachikawa
  • Organizer: 8th International Conference on Nano-Molecular Electronics
  • Place of Presentation: Kobe
  • Year and Date: 2008-12-16
• [Presentation] A DFT and MD study on the evaporation dinamics of water moleculeson carbon nano-materials (2008)
  • Author(s): S. Abe, Y. Nagoya, F. Watari and H. Tachikawa
  • Organizer: 8^<th> International Conference on Nano-Molecular Electronics
  • Place of Presentation: Kobe, Portpia Hotel
  • Year and Date: 2008-12-16
• [Presentation] Internal distribution behavior of inorganic particles in mice (2008)
  • Author(s): S. Abe, T. Yonezawa, C. Koyama, T. Akasaka, M. Uo, Y. Kuboki, and F. Watari
  • Organizer: 21st International symposium of microprocesses and nanotechnology
  • Place of Presentation: Fukuoka
  • Year and Date: 2008-10-29
• [Presentation] Internal distribution behavior of inorganic particles in mice (2008)
  • Author(s): S. Abe, T. Yonezawa, C. Koyama, T. Akasaka, M. Uo, Y. Kuboki, and F. Watari
  • Organizer: 21^<st> International symposium of microprocesses and nanotechnology
  • Place of Presentation: Fukuoka, JAL Resort Se a Hawks Hotel
  • Year and Date: 2008-10-29
• [Presentation] Biodistribution of several inorganic micro/nano particles in mice (2008)
  • Author(s): S. Abe, C. Koyama, T. Akasaka, M. Uo, Y. Kuboki, and F. Watari
  • Organizer: 21st International Symposium on Ceramics in Medicine (Bioceramics21)
  • Place of Presentation: Buzios
  • Year and Date: 2008-10-22
• [Presentation] Biodistribution of several inorganic micro/nano particles in mice (2008)
  • Author(s): S. Abe, C. Koyama, T. Akasaka, M. Uo, Y. Kuboki, and F. Watari
  • Organizer: 21^<st> International Symposium on Ceramics in Medicine(Bioceramics21)
  • Place of Presentation: Buzios, Atlantico Buzios Convention & Resort
  • Year and Date: 2008-10-22
• [Presentation] ナノカーボン物質と磁性金属イオン(Mn2+)との相互作用に関する理論的研究 (2008)
  • Author(s): 阿部薫明、亘理文夫、高田知哉、田地川浩人
  • Organizer: 平成20年度第2回分子科学討論会
  • Place of Presentation: 福岡
  • Year and Date: 2008-09-26
• [Presentation] ナノカーボン物質と磁性金属イオン(Mn^<2+>)との相互作用に関する理論的研究 (2008)
  • Author(s): 阿部薫明、亘理文夫、高田知哉、田地川浩人
  • Organizer: 平成20年度第2回分子科学討論会
  • Place of Presentation: 福岡市、福岡国際会議場
  • Year and Date: 2008-09-26
• [Presentation] バイオミメティクポリマーによる石灰化反応の制御 (2008)
  • Author(s): 石田智毅、阿部薫明、赤坂司、宇尾基弘、亘理文夫
  • Organizer: 平成20年度秋期第52回日本歯科理工学会学術講演会
  • Place of Presentation: 吹田
  • Year and Date: 2008-09-21
• [Presentation] バイオミメティクポリマーによる石灰化反応の制御 (2008)
  • Author(s): 石田智毅、阿部薫明、赤坂司、宇尾基弘、亘理文夫
  • Organizer: 平成20年度秋期第52回日本歯科理工学会学術講演会
  • Place of Presentation: 吹田市、千里ライフサイエンスセンター
  • Year and Date: 2008-09-21
• [Presentation] マウス体内での投与粒子の分布・拡散挙動の可視化 (2008)
  • Author(s): 阿部薫明、小山千佳、赤坂司、宇尾基弘、久保木芳徳、亘理文夫
  • Organizer: 平成20年度日本歯科理工学会北海道・東北支部夏期セミナー
  • Place of Presentation: 千歳
  • Year and Date: 2008-08-24
• [Presentation] マウス体内での投与粒子の分布・拡散挙動の可視化 (2008)
  • Author(s): 阿部薫明、小山千佳、赤坂司、宇尾基弘、久保木芳徳、亘理文夫
  • Organizer: 平成20年度日本歯科理工学会北海道・東北支部夏期セミナー
  • Place of Presentation: 千歳市、丸駒温泉
  • Year and Date: 2008-08-24
• [Presentation] A DFT and MD study on the interaction of carbon nano-materials with metal ions (2008)
  • Author(s): S. Abe, F. Watari and H. Tachikawa
  • Organizer: International Symposium on Multi-scale Simulationsof Biological and Soft Materials
  • Place of Presentation: Tokyo
  • Year and Date: 2008-06-19
• [Presentation] A DFT and MD study on the interaction of carbon nano-materials with metal ions (2008)
  • Author(s): S. Abe, F. Watari and H. Tachikawa
  • Organizer: International Symposium on Multi-scale Simulationsof Biological and Soft Materials
  • Place of Presentation: Tokyo, Akihabara Cross Field
  • Year and Date: 2008-06-19
• [Presentation] Distribution imaging of mangetic particles in mice compared with magnetic resonance imaging and X-ray scanning analytical microscope (2008)
  • Author(s): M. Esaki, S. Abe, T. Akasaka, M. Uo, T. Hosono, Y. Sato, B. Jeyadevan, Y. Kuboki, M. Morita, K. Tohji, and F. Watari
  • Organizer: International Symposium on "Nanotoxicology Assessment and Biomedical Application of Fine Particles and Nanotubes
  • Place of Presentation: Sapporo
  • Year and Date: 2008-06-17
• [Presentation] Distribution imaging of mangetic particles in mice compared with magnetic resonance imaging and X-ray scanning analytical microscope (2008)
  • Author(s): M. Esaki, S. Abe, T. Akasaka, M. Uo, T. Hosono, Y. Sato , B. Jeyadevan, Y. Kuboki, M. Morita, K. Tohji, and F. Watari
  • Organizer: International Symposium on " Nanotoxicology Assessment and Biomedical Application of Fine Particles and Nanotubes "
  • Place of Presentation: Sapporo, Hokkaido Uni versity
  • Year and Date: 2008-06-17
• [Presentation] Imaging of biodistribution of organic- / inorganic- particles in mice (2008)
  • Author(s): S. Abe, C. Koyama, T. Akasaka, M. Uo, Y. Kuboki, and F. Watari
  • Organizer: International Symposium on "Nanotoxicology Assessment and Biomedical Application of Fine Particles and Nanotubes
  • Place of Presentation: Sapporo
  • Year and Date: 2008-06-16
• [Presentation] Imaging of biodistribution of organic-/inorganic-particles in mice (2008)
  • Author(s): S. Abe, C. Koyama, T. Akasaka, M. Uo, Y Kuboki, and F. Watari
  • Organizer: International Symposium on " Nanotoxicology Assessment and Biomedical Application of Fine Particles and Nanotubes "
  • Place of Presentation: Sapporo, Hokkaido Uni versity
  • Year and Date: 2008-06-16
• [Presentation] Determination of administered organic/inorganic particles in mice (2008)
  • Author(s): S. Abe, C. Koyama, M. Esaki, I. Kida, I. Rosca, T. Akasaka, M. Uo, M. Morita, Y. Sato, B. Jeyadevan, Y. Kuboki, K. Tohji, F. Watari
  • Organizer: 8th World Biomaterial Congress 2008
  • Place of Presentation: Amsterdam
  • Year and Date: 2008-05-31
• [Presentation] Determination of administered organic/inorganic particles in mice (2008)
  • Author(s): S. Abe, C. Koyama, M. Esaki, I. Kida, I. Rosca, T. Akasaka, M. Uo, M. Morita, Y. Sato, B. Jeyadevan, Y. Kuboki, K. Tohji, F. Watari
  • Organizer: 8^<th> World Biomaterial Congress 2008
  • Place of Presentation: Amsterdam, Rai Convent ion Center
  • Year and Date: 2008-05-31
• [Presentation] 有機・無機マイクロ粒子の生体内での分布状態の可視化 (2008)
  • Author(s): 阿部薫明、小山千佳、江崎光恵、Iosif Rosca、赤坂司、宇尾基弘、森田学、久保木芳徳、亘理文夫
  • Organizer: 平成20年度春期第51回日本顕微鏡学会学術講演会
  • Place of Presentation: 京都
  • Year and Date: 2008-05-21
• [Presentation] 有機・無機マイクロ粒子の生体内での分布状態の可視化 (2008)
  • Author(s): 阿部薫明、小山千佳、江崎光恵、Iosif Rosca、赤坂司、宇尾基弘、森田学、久保木芳徳、亘理文夫
  • Organizer: 平成20年度春期第51回日本顕微鏡学会学術講演会
  • Place of Presentation: 京都市、京都国際会館
  • Year and Date: 2008-05-21
• [Presentation] 各種マイクロ・ナノ粒子の生体内での分布状態の追跡とその可視化 (2008)
  • Author(s): 阿部薫明、江崎光恵、赤坂司、宇尾基弘、久保木芳徳、亘理文夫
  • Organizer: 平成20年度春期第51回日本歯科理工学会学術講演会
  • Place of Presentation: 横浜
  • Year and Date: 2008-04-27
• [Presentation] 各種マイクロ・ナノ粒子の生体内での分布状態の追跡とその可視化 (2008)
  • Author(s): 阿部薫明、江崎光恵、赤坂司、宇尾基弘、久保木芳徳、亘理文夫
  • Organizer: 平成20年度春期第51回日本歯科理工学会学術講演会
  • Place of Presentation: 横浜市、鶴見大学記念館
  • Year and Date: 2008-04-27
• [Presentation] マウス体内での有機・無機粒子の体内循環挙動の追跡 (2008)
  • Author(s): 阿部薫明、小山千佳、江崎光恵、Iosif Danel Rosca、赤坂司、宇尾基弘、森田学、久保木芳徳、亘理文夫
  • Organizer: 第20回代用臓器・再生医学研究会
  • Place of Presentation: 北海道大学・札幌
  • Year and Date: 2008-02-02
• [Presentation] マウス体内での有機・無機粒子の体内循環挙動の追跡 (2008)
  • Author(s): 阿部薫明、小山千佳、江崎光恵、IosifRosca、赤坂司、宇尾基弘、森田学、久保木芳徳、亘理文夫
  • Organizer: 第20回代用臓器・再生医学研究会
  • Place of Presentation: 札幌市・北海道大学
  • Year and Date: 2008-02-02
• [Presentation] カーボンナノ材料と金属イオン(Mn2+)との相互作用に関する理論的研究 (2008)
  • Author(s): 阿部薫明、亘理文夫、田地川浩人
  • Organizer: 北海道支部2008年冬季研究発表会
  • Place of Presentation: 札幌
  • Year and Date: 2008-01-30
• [Presentation] カーボンナノ材料と金属イオン(Mn^<2+>)との相互作用に関する理論的研究 (2008)
  • Author(s): 阿部薫明、亘理文夫、田地川浩人
  • Organizer: 北海道支部2008年冬季研究発表会
  • Place of Presentation: 札幌市・北海道大学
  • Year and Date: 2008-01-30
• [Presentation] (2007)
  • Author(s): 阿部薫明、小山千佳、江崎光恵、I. D. Rosca、赤坂司、宇尾基弘、森田学、久保木芳徳、亘理文夫
  • Organizer: 第5回「ナノトキシコロジーアセスと微粒子・ナノチューブのバイオ応用」研究会
  • Place of Presentation: 名古屋
  • Year and Date: 2007-12-18
• [Presentation] 各種マイクロ・ナノ粒子の生体内での分布状態の追跡とその可視化 (2007)
  • Author(s): 阿部薫明、小山千佳、江崎光恵、IosifRosca、赤坂司、宇尾基弘、森田学、久保木芳徳、亘理文夫
  • Organizer: 第5回「ナノトキシコロジーアセスと微粒子・ナノチューブのバイオ応用」研究会
  • Place of Presentation: 名古屋市・(財)ファインセラミックセンター
  • Year and Date: 2007-12-18
• [Presentation] 有機・無機微粒子の体内動態イメージング法の検討、各種マイクロ・ナノ粒子の生体内での分布状態の追跡とその可視 (2007)
  • Author(s): 阿部薫明、小山千佳、I. D. Rosca、赤坂司、宇尾基弘、久保木芳徳、亘理文夫
  • Organizer: 第29回日本バイオマテリアル学会
  • Place of Presentation: 吹田
  • Year and Date: 2007-11-27
• [Presentation] 有機・無機微粒子の体内動態イメージング法の検討 (2007)
  • Author(s): 阿部薫明、小山千佳、IosifRosca、赤坂司、宇尾基弘、久保木芳徳、亘理文夫
  • Organizer: 第29回日本バイオマテリアル学会
  • Place of Presentation: 豊中市・千里ライフサイエンスセンター
  • Year and Date: 2007-11-27
• [Presentation] 、Determination of administered magnetite nanoparticles in mice: Magnetic resonance imaging and X-ray scanning electronic microscope (2007)
  • Author(s): M. Esaki, Shigeaki Abe, I. Kida, T. Akasaka, M. Uo, Y. Kuboki, F. Watari
  • Organizer: Determination of administered magnetite nanoparticles in mice: Magnetic resonance imaging and X-ray scanning electronic microscope
  • Place of Presentation: Bangkok
  • Year and Date: 2007-11-24
• [Presentation] 、Visualization of distribution of inorganic micro/nano particles in mice using X-ray scanning electronic microscope (2007)
  • Author(s): S. Abe, C. Koyama, T. Akasaka, M. Uo, Y. Kuboki, F. Watari
  • Organizer: International Dental Materials Congress 2007
  • Place of Presentation: Imperial Queen's Hotel・Bangkok
  • Year and Date: 2007-11-24
• [Presentation] Visualization of distribution of inorganic micro/nano particlesin mice using X-ray scanning electronic microscope. (2007)
  • Author(s): Shigeaki Abe, Chika Koyama, Tsukasa Akasaka, Motohiro Uo, Yoshinori Kuboki, Fumio Watari
  • Organizer: International Dental Materials Congress 2007
  • Place of Presentation: バンコク市・The imperial Queen's Park Hotel
  • Year and Date: 2007-11-24
• [Presentation] Determination of administered magnetite nanoparticles inmice: Magnetic resonance imaging and X-ray scanning electronic microscope. (2007)
  • Author(s): Mitsue Esaki, Shigeaki Abe, Ikuhiro Kida, Tsukasa Akasaka, Motohiro Uo, Yoshinori Kuboki, Fumio Watari
  • Organizer: International Dental Materials Congress 2007
  • Place of Presentation: バンコク市・The imperial Queen's Park Hotel
  • Year and Date: 2007-11-24
• [Presentation] マウスに投与したマイクロ・ナノ微粒子の体内動態の可視化法の開発 (2007)
  • Author(s): 阿部薫明、小山千佳、I. D. Rosca、赤坂司、宇尾基弘、古月文志、久保木芳徳、亘理文夫
  • Organizer: 第4回「ナノトキシコロジーアセスと微粒子・ナノチューブのバイオ応用」研究会
  • Place of Presentation: 東京
  • Year and Date: 2007-08-01
• [Presentation] マウスに投与したマイクロ・ナノ微粒子の体内動態の可視化法の開発 (2007)
  • Author(s): 阿部薫明、小山千佳、IosifRosca、赤坂司、宇尾基弘、古月文志、久保木芳徳、亘理文夫
  • Organizer: 第4回「ナノトキシコロジーアセスと微粒子・ナノチューブのバイオ応用」研究会
  • Place of Presentation: 東京都・タワーホール船堀
  • Year and Date: 2007-08-01
• [Presentation] 各種金属微粒子の体内動態のイメージング (2007)
  • Author(s): 阿部薫明、赤坂司、宇尾基弘、久保木芳徳、亘理文夫
  • Organizer: 平成19年度春期第49回日本歯科理工学会学術講演会
  • Place of Presentation: 札幌
  • Year and Date: 2007-05-13
• [Presentation] 各種金属微粒子の体内動態のイメージング (2007)
  • Author(s): 阿部薫明、赤坂司、宇尾基弘、久保木芳徳、亘理文夫
  • Organizer: 平成19年度春期第49回日本歯科理工学会学術講演会
  • Place of Presentation: 札幌市・札幌コンベンションセンター
  • Year and Date: 2007-05-13