| Project/Area Number |
19791462
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
補綴理工系歯学
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| Research Institution | Nihon University |
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Principal Investigator |
NAKADA Hiroshi Nihon University, 松戸歯学部, 講師 (10349970)
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| Co-Investigator(Renkei-kenkyūsha) |
SAKAE Toshiro 日本大学, 松戸歯学部, 准教授 (20112948)
NUMATA Yasuko 日本大学, 松戸歯学部, 大学院生
LEGEROS Racquel Z. University College of Dentistry, Department of Biomaterials & Biomimetics, Professor
LEGEROS John P New York University College of Dentistry, Department of Biomaterials & Biomimetics, Professor
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥3,860,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2007: ¥1,000,000 (Direct Cost: ¥1,000,000)
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| Keywords | 歯学 / 細胞・組織 / 骨 / 動物 / インプラント |
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| Research Abstract |
The purpose of this study was to investigate changes in bone quality associated with the mineralization of new bone forming around implants. This study investigated the quality and composition of new bone that formed around implants at 4 and 8 weeks post-implantation, compared to those of cortical bone. In new bone near cortical bone, PO_4^<3->, CO_3^<2->, and amide I distributions increased over time, and calcification progressed. In new bone more distant from cortical bone, PO_4^<3->, CO_3^<2->, and amide I distributions also increased over time, but to a lesser extent compared to that close to cortical bone. Our findings clearly showed changes in bone quality related to the degree of mineralization, based on sequential changes in chemical bonding and the distribution of elements and molecules comprising bone.
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