Central mechanisms involved in masticatory movements

• Project/Area Number: 19791466
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: 補綴理工系歯学
• Research Institution: Nihon University
• Principal Investigator: LEE Jun Nihon University, 歯学部, 助教 (10386055)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥3,780,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥480,000); Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2007: ¥1,700,000 (Direct Cost: ¥1,700,000)
• Keywords: ドパミン / 大脳基底核 / 顎運動 / ドパミン神経系 / 側坐核 / ドパミンD_1受容体 / ドパミンD_2受容体 / 視床背内側核 / アセチルコリン受容体 / turning behaviour / アデニル酸シクラーゼ / ホスホリパーゼC / bisphenol-A

Research Abstract

本研究では、以下の検討を行った。(1)2種類のドパミンD1受容体アゴニスト(アデニル酸シクラーゼ活性化型、ホスホリパーゼC活性化型)は、顎運動を発現するが、そのタイプによってD1受容体の関与様式が異なることが示唆された。(2)内分泌攪乱物質を幼若期に投与したラット群と対照群とでは、ドパミン依存性の行動に差が認められなかった。したがって、内分泌攪乱物質処置ラットの多動症モデルとしての有用性は限られたものであることが考えられた。(3)側坐核からの遠心性投射路の一つとして考えられる視床背内側核(mdT)のGABAA受容体の役割について検討した結果、mdTのGABAA受容体は側坐核のアセチルコリン受容体機能に重要な役割を果たすことが明らかとなった。

Research Products

• [Journal Article] GABAA receptors in the mediodorsal thalamus play a crucial role in rat shell-specific acetylcholine-mediated, but not dopamine-mediated (2009)
  • Author(s): Ikeda H, Kotani A, Lee J, Koshikawa N, Cools AR
  • Journal Title: turning behaviour. Neuroscience Vol. 159 Pages: 1200-1207
  • Peer Reviewed
• [Journal Article] GABA(A)receptors in the mediodorsal thalamus play a crucial role in rat shell-specific acetylcholine-mediated, but not dopamine-mediated, turning behaviour (2009)
  • Author(s): H. Ikeda, A. Kotani, J. Lee, N. Koshikawa, AR. Cools
  • Journal Title: Neuroscience 159 Pages: 1200-1207
  • Peer Reviewed
• [Journal Article] 5-HT1A and 5-HT1B receptors in the ventrolateral striatum differentially modulate apomorphine-induced jaw movements in rats (2008)
  • Author(s): Fujita S, Kiguchi M, Lee J, Terakado M, Suga K, Hatanaka H, Koshikawa N
  • Journal Title: Journal of Oral Science Vol. 50, No. 4 Pages: 387-395
  • NAID: 130000072796
  • Peer Reviewed
• [Journal Article] 5-HT(1A)and 5-HT(1B)receptors in the ventrolateral striatum different ially modulate apomorphine-induced jaw movements in rats (2008)
  • Author(s): S. Fujita, M. Kiguchi, J. Lee, M. Terakado, K. Suga, H. Hatanaka, N. Koshikawa
  • Journal Title: Journal of Oral Science 50-4 Pages: 387-395
  • Peer Reviewed
• [Journal Article] Behavioral responses to methylphenidate and apomorphine in rats exposed neonatally to bisphenol-A (2007)
  • Author(s): Kiguchi M, Fujita S, Lee J, Shimizu N, Koshikawa N
  • Journal Title: Journal of Oral Science vol No.4 Pages: 311-318
  • NAID: 130000072882
  • Peer Reviewed
• [Journal Article] Behavioral responses to methylphenidate and apomorphine in ratsexposed neonatally to bisphenol-A (2007)
  • Author(s): M. Kiguchi
  • Journal Title: Journal of Oral Science 49-4 Pages: 311-318
  • Peer Reviewed