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The development for newly treatment of oral cancer by transfection of RIG-I, novel differentiation induction gene

Research Project

Project/Area Number 19791479
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Surgical dentistry
Research InstitutionHirosaki University

Principal Investigator

SAKAKI Hirotaka  Hirosaki University, 医学部附属病院, 助教 (90374850)

Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥3,480,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥480,000)
Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2007: ¥1,400,000 (Direct Cost: ¥1,400,000)
KeywordsRIG-I / poly-IC / 口腔癌細胞
Research Abstract

RIG-Iその機能はいまだ明らかにされていない新規の遺伝子である。
申請者はRIG-I遺伝子を用いた新たな遺伝子治療の可能性に着目し、これまで遂行してきたRIG-I遺伝子の機能解析に加え、口腔癌由来細胞株を用い、RIG-I遺伝子の腫瘍抑制遺伝子としての可能性を検討し、同遺伝子を用いた遺伝子治療につながる基礎的研究を行った。
その結果、RIG-I遺伝子導入によって口腔癌由来細胞株においてG1/S期およびG2/M期進行が抑制されることが推測された。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (2 results)

All 2008

All Journal Article (2 results) (of which Peer Reviewed: 2 results)

  • [Journal Article] A case of pleomorphic adenoma in the palate detected by positron emission tomography/computed tomography screening for cancer2008

    • Author(s)
      Sakaki H、 Satoh H、 Kobayashi W、Narita K、Asano T、Kimura H
    • Journal Title

      Asian J Oral Maxillofac Surg 20

      Pages: 97-101

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] A case of pleomorphic adenoma in the palate detected by positron emissiontomography / computed tomography screening for cancer2008

    • Author(s)
      Sakaki H
    • Journal Title

      Asian J Oral Maxillofac Surg 20

      Pages: 97-101

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed

URL: 

Published: 2007-04-01   Modified: 2016-04-21  

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