Analysis of NFAT signaling of osseous cells of iso-grafted bonetreated with topical administration of immunosuppressant agent.

• Project/Area Number: 19791485
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Surgical dentistry
• Research Institution: Tohoku University
• Principal Investigator: HIROTAN Hiroaki Tohoku University, 病院, 助教 (90312595)
• Project Period (FY): 2007 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥3,860,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥660,000); Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2008: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2007: ¥1,000,000 (Direct Cost: ¥1,000,000)
• Keywords: 口腔外科学一般 / 破骨細胞 / 骨芽細胞 / 免疫抑制剤 / 移植 / NFAT / 移植骨

Research Abstract

The present study was undertaken to analyze NFAT signaling of osseous cells of iso-grafted bone treated with topical administration of immunosuppressant drug, cyclosporine A. The iso-grafted bone was dissected and taken by soft X-ray. Topical cyclosporine A had no effect on bone mineral content. Topical cyclosporine A decreased the number of osteoclast and osteoblast. These results suggest that topical cyclosporine A decreased bone turnover of iso-grafted bone and another data suggest that NFAT is involved in Fas-mediated apoptosis of osseous cells.