Self-Assembling Peptide Nanofiber Scaffolds, Platelet Rich Plasma, and Mesenchymal Stem Cells for Injectable Bone Regeneration with Tissue Engineering

• Project/Area Number: 19791505
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Surgical dentistry
• Research Institution: Nagoya University
• Principal Investigator: KENJI Ito Nagoya University, 医学部・附属病院, 病院助教 (50402623)
• Project Period (FY): 2007 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥3,800,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥600,000); Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2007: ¥1,200,000 (Direct Cost: ¥1,200,000)
• Keywords: 未分化間葉系幹細胞 / ナノ材料再生医学 / 3Dマトリックス / 骨再生療法 / ナノ材料 / 再生医学 / 未分化間葉系細胞

Research Abstract

The purpose of this study was to investigate a capability of 3D PuraMatrix^<TM> (PM), which is a self-assembling peptide nanomaterial, as a scaffold for bone regeneration in combination with dog mesenchymal stem cells (dMSCs) and/or platelet-rich plasma (PRP) using tissue engineering and regenerative medicine (TERM) technology. This report showed that MSCs might keep their own potential and promote new bone regeneration in the three-dimensional structure by PM scaffolds. Taken together, it is suggested that PM might be useful as a scaffold of bone regeneration in cell therapy, and these results might lead to an effective treatment method for bone defects.

Research Products

• [Journal Article] Self-assembling peptide nanofiber scaffolds, platelet-rich plasma, and mesenchymal stem cells for injectable bone regeneration with tissue engineering. (2009)
  • Author(s): Yoshimi R, Yamada Y, Ito K, Nakamura S, Abe A, Nagasaka T, Okabe K, Kohgo T, Baba S, Ueda M.
  • Journal Title: J Craniofac Surg. 20 Pages: 1523-1530
  • Peer Reviewed
• [Journal Article] Self-assembling peptide nanofiber scaffolds, platelet rich plasma, and mesenchymal stem cells for injectable bone regeneration with tissue engineering. (2009)
  • Author(s): Yoshimi, R.
  • Journal Title: J Craniofac Surg. 20 Pages: 1523-1530
  • Peer Reviewed
• [Presentation] A novel sinus augmentation using tissue-engineered bone for immediate function (2008)
  • Author(s): N Sayaka, Y. Yoichi, K. Ito, H. Hideharu, and Minoru Ueda.
  • Organizer: 17^<th> annual scientific meeting of European association for osseointegration
  • Place of Presentation: Warsaw, Poland
• [Presentation] ナノテクノロジーによる新規3次元マトリックスの再生医学的骨再生法への応用 (2007)
  • Author(s): 吉見涼子、山田陽一、伊藤憲治上田実, 他
  • Organizer: 第52回日本口腔外科学会総会
  • Place of Presentation: 名古屋国際会議場. 日本
• [Presentation] ナノテクノロジーによる新規3次元マトリックスの再生医学的骨再生法への応用 (2007)
  • Author(s): 吉見涼子、山田陽一、伊藤憲治 上田 実, 他
  • Organizer: 第52回 日本口腔外科学会総会
  • Place of Presentation: 名古屋国際会議場.日本
• [Book] 再生医療とインプラント (2007)
  • Author(s): 伊藤 憲治
  • Total Pages: 207
  • Publisher: クインテッセンス出版株式会社