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siRNA therapy targeting DIF・PDE1 signaling in malignant melanoma

Research Project

Project/Area Number 19791508
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Surgical dentistry
Research InstitutionMie University

Principal Investigator

SHIMIZU Kasumi  Mie University, 医学部・附属病院, 助教 (20378368)

Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥3,660,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2007: ¥2,100,000 (Direct Cost: ¥2,100,000)
Keywords悪性黒色腫 / Phosphodiesterase 1 / Phosphodiesterasa 1
Research Abstract

悪性腫瘍細胞で細胞内のセカンドメッセンジャーであるcAMP等を分解しその濃度を調整しているphosphodiesterase (PDE)1アイソザイム(PDE1A, PDE1B, PDE1C)のいくつかが発現していることを確認した. PDE1Cの遺伝子変異部分に対するsiRNAを作成し, 導入を行った. 細胞増殖はやや抑制された. 科学研究費若手研究(B)(平成21, 22年度)では転移との関係を解明する予定である.

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (3 results)

All 2009 2008 Other

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (1 results)

  • [Journal Article] Characterization of Phosphodiesterase 1 in Human Malignant Melanoma Cell Lines.2009

    • Author(s)
      Kasumi Shimizu, Taku Murata, Yoshihiro Watanabe, Chu Sato, Hiroshi Morita and Toshiro Tagawa.
    • Journal Title

      Anticancer Research. 29(4)

      Pages: 1119-1122

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Characterization of Phosphodiesterase 1 in Human Malignant Melanoma Cell Lines

    • Author(s)
      Kasumi Shimizu
    • Journal Title

      Anticancer Research (in press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] 分化誘導因子による悪性黒色腫細胞増殖抑制効果の検討2008

    • Author(s)
      清水香澄, 村田琢, 渡邉由裕, 溝井心, 鈴木智子, 森田寛, 平本憲一, 田川俊郎
    • Organizer
      第51回日本口腔科学会中部地方部会
    • Place of Presentation
      愛知学院大学(名古屋市)
    • Year and Date
      2008-10-11
    • Related Report
      2008 Annual Research Report 2008 Final Research Report

URL: 

Published: 2007-04-01   Modified: 2016-04-21  

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