Role of grafted nerve to saliva secretion in submandibular gland allograft
| Project/Area Number |
19791510
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Surgical dentistry
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| Research Institution | Osaka University |
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Principal Investigator |
ISOMURA Emiko Osaka University, 歯学部附属病院, 医員 (70397701)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥5,247,099 (Direct Cost: ¥4,543,923、Indirect Cost: ¥703,176)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,617,099 (Direct Cost: ¥1,243,923、Indirect Cost: ¥373,176)
Fiscal Year 2007: ¥2,200,000 (Direct Cost: ¥2,200,000)
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| Keywords | 口腔外科一般 / 顎下腺 / 他家移植 / 神経再生 / 唾液腺 / 神経移植 / 唾液分泌 |
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| Research Abstract |
Using a vascularized submandibular gland transplantation method, we extracted portions of the submandibular gland including the duct from beagle dogs and placed them into the submental region of age- and weight- matched dogs. Differences in the amount of saliva secretion and histologic appearance were compared based of the existence of chorda tympani branches in the allograft.
At 10 weeks after transplantation, the amount of resting saliva in the group grafted with the nerve was clearly increased, whereas the quantity of that in the group that underwent transplantation without the nerve was quite low. In the former group, responses were demonstrated after taste stimulation and electronic nerve stimulation.
Our results showed a clear relationship between the presence of a nerve in grafted submandibular glands and saliva secretion.
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Report
(4 results)
Research Products
(1 results)
