Diagnostic value of dynamic contrast-enhanced MRI in the salivary gland tumors

• Project/Area Number: 19791518
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Surgical dentistry
• Research Institution: Okayama University
• Principal Investigator: HISATOMI Miki Okayama University, 大学院・医歯薬学総合研究科, 助教 (60314704)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥2,840,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥240,000); Fiscal Year 2008: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2007: ¥1,800,000 (Direct Cost: ¥1,800,000)
• Keywords: 歯科放射線診断学 / dynamic CE-MRI / 唾液腺腫瘍 / 口腔癌 / 多形性腺腫 / ワルチン腫瘍

Research Abstract

造影剤を静脈から速やかに注入し,目的部位について造影剤流入時の時間的変化を画像化したものがdynamic CE-MRIである。唾液腺腫瘍の中でも高頻度に認められる良性腫瘍の多形性腺腫とワルチン腫瘍および悪性腫瘍の粘表皮癌と腺様嚢胞癌において、このdynamic CE-MRIが鑑別に有用であった研究結果を英文雑誌に報告した(Oral Oncol. 2007 43(9):940-7)。ワルチン腫瘍は、急増・急減の特異的な造影効果を現し、診断学上、重要な結果を得られた。また、dynamic CE-MRIのパラメーターのうち、Tmax(最も高い造影効果の値を示した時間)とWashout ratio(造影剤の排出の割合)が診断に有用であった。

Research Products

• [Journal Article] Dynamic contrast-enhanced magnetic resonance imaging for estimating tumor proliferation and microvessel density oforal squamous cell carcinomas (2008)
  • Author(s): Unetsubo T, Konouchi H, Yanagi Y,Murakami J, Fujii M, Matsuzaki H, Hisatomi M, Nagatsuka H
  • Journal Title: Asaumi JI.Oral Oncol (Epub ahead of print)
  • Peer Reviewed
• [Journal Article] Diagnostic value of dynamic contrast-enhanced MRI in the salivary gland tumors (2007)
  • Author(s): Hisatomi M, Asaumi J, Yanagi Y, Unetsubo T,Maki Y, Murakami J, Matsuzaki H, Honda Y, Konouchi H
  • Journal Title: Oral Oncol 43(9) Pages: 940-7
  • Peer Reviewed
• [Journal Article] Diagnostic value of dynamic contrast-enhanced MRI in the salivary gland tumors. (2007)
  • Author(s): Hisatomi M, Asaumi J, et. al.
  • Journal Title: Oral Oncology 43 Pages: 940-947
  • Peer Reviewed
• [Journal Article] Dynamic contrast-enhanced magnetic resonance imaging for estimating tumor proliferation and microvessel density of oral squamous cell carcinomas
  • Author(s): Unetsubo T, Konouchi H, Yanagi Y, Murakami J, Fujii M, Matsuzaki H, Hisatomi M, Nagatsuka H, Asaumi JI.
  • Journal Title: Oral Oncology (In press [Epub ahead of print])
  • Peer Reviewed
• [Presentation] Dynamic contrast-enhanced magnetic resonance imaging for estimatimg tumor proliferation and microvessel density oforal squamous cell carcinoma (2008)
  • Author(s): Unetsubo T, Konouchi H, Yanagi Y,Murakami J, Matsuzaki H, Hisatomi M, Asaumi JI.
  • Organizer: The 7th Asian Congress of Oral and Maxillo-Facial Radiology,The 13th Conference of Clinical Diagnostics of JSOMR
  • Place of Presentation: Nara、Japan
• [Presentation] Diagnostic value of dynamic contrast-enhanced MRI in the salivary gland tumors (2008)
  • Author(s): Hisatomi M, Asaumi JI, Yanagi Y, Unetsubo T, Maki Y, Murakami J, Matsuzaki H, Honda Y, Konouchi H
  • Organizer: 日本歯科放射線学会第5回総会・第49回学術大会
  • Place of Presentation: 名古屋
• [Presentation] Dynamic contrast-enhanced magnetic resonance imaging for estimatimg tumor proliferation and microvessel density of oral squamous cell carcinoma (2008)
  • Author(s): Unetsubo T, Konouchi H, Yanagi Y, Murakami J, Matsuzaki H, Asaumi JI.
  • Organizer: The 7th Asian Congress of Oral and Maxillo-Facial Radiology, The 13th Conference of Clinical Diagnostics of JSOMR
  • Place of Presentation: 奈良