Identification of new oral cancer biomarker through the screening ofsecreted and cell surface protein

• Project/Area Number: 19791521
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Surgical dentistry
• Research Institution: Hiroshima University
• Principal Investigator: MITANI Yoshitsugu Hiroshima University, 病院, 歯科診療医 (30432678)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥3,690,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥390,000); Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2007: ¥2,000,000 (Direct Cost: ¥2,000,000)
• Keywords: 悪性腫瘍 / 新規癌バイオマーカー / 分泌蛋白質 / 膜蛋白質

Research Abstract

分泌蛋白質もしくは膜蛋白質はがんにおいて重要な役割を果たしており、診断マーカーや分子標的治療となりうる可能性を持っている。本研究はこの分泌蛋白質、膜蛋白質のみに限定したスクリーニング法を利用し、新規口腔癌バイオマーカーの同定を試みた。今回残念ながら新規マーカーの同定には至らなかったが、いくつかの膜蛋白、分泌蛋白が得られた。今後継続して研究を行うことで、新規癌マーカーが得られると考えられた。

Research Products

• [Journal Article] Expression of epiregulin,a novel epidermal growth factor ligand associated with prognosis in humanoral squamous cell carcinomas (2008)
  • Author(s): Shigeishi H, Higashikawa K, Hiraoka M, Fujimoto S, Mitani Y, Ohta K, TakechiM, Kamata N
  • Journal Title: OncolRep 19(6) Pages: 1557-1564
  • Peer Reviewed
• [Journal Article] Expression of epiregulin, a novel epidermal growth factor ligand associated with prognosis in human oral squamous cell carcinomas (2008)
  • Author(s): Shigeoshi Hideo
  • Journal Title: Oncology Reports 19(6) Pages: 1557-1564
  • Peer Reviewed
• [Journal Article] Reg IV is a serum biomarker for gastric cancer patients and predicts response to 5-fluorouracil-based chemotherapy (2007)
  • Author(s): Mitani Y, Oue N, Matsumura S, Yoshida K, Noguchi T, Ito M, Tanaka S, Kuniyasu H, Kamata N, Yasui W
  • Journal Title: Oncogene 26(30) Pages: 4383-4393
  • NAID: 120000875405
  • Peer Reviewed
• [Journal Article] DNA demethylation of vascular endothelial growth factor-C is associated with gene expression and its possible involvement of lymphangiogenesis in gastric cancer (2007)
  • Author(s): Matsumura S, Oue N, Mitani Y, Kitadai Y, Yasui W
  • Journal Title: Int J Cancer 120(8) Pages: 1689-1695
  • Peer Reviewed
• [Journal Article] Reg IV is a serum biomarer for gastric canstric cancer patients and predicts response to 5-fluorouracil-based chemotherapy. (2007)
  • Author(s): Yoshitsugu Mitani
  • Journal Title: Oncogene 26(30) Pages: 4383-4393
  • Peer Reviewed
• [Journal Article] DNA ethylation of vascular endothelial growth factor-C asociated with gene expression and its possible involvement of lymphangiogenesis in gastric cancer. (2007)
  • Author(s): Shunji Matsumura
  • Journal Title: International Journal of Cancer 120(8) Pages: 1689-1695
  • Peer Reviewed