The involvement of Ephrin signaling in the invasion and metastas is of squamous cell carcinoma cells

• Project/Area Number: 19791528
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Surgical dentistry
• Research Institution: Kochi University
• Principal Investigator: SASABE Eri Kochi University, 教育研究部・医療学系, 助教 (40363288)
• Project Period (FY): 2007 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥5,060,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥660,000); Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2007: ¥2,200,000 (Direct Cost: ¥2,200,000)
• Keywords: 癌 / 遺伝子 / 細胞 / 組織 / 発現制御 / シグナル伝達 / Eph / Ephrin / 口腔扁平上皮癌 / 浸潤 / 転移

Research Abstract

Eph/Ephrin mRNA and protein were expressed in oral squamous cell carcinoma (OSC) cells. EphrinB2 was especially overexpressed in oral squamous cell carcinoma and high invasive OSC cells. The proliferation, attachment, and invasion were suppressed in EphrinB2 knock-downed cells as compared with control cells. The treatment with EphB/Fc chimera promoted the attachment, but inhibited the invasion of EphrinB2 knock-downed cells. these results suggest that EphrinB2 contributes to the proliferation, attachment, and invasion of OSC cells.

Research Products

• [Journal Article] Reantive oxygen species produced by the knockdown of manganese-superoxide dismutase up-regulate hypoxia-inducible factor-lalpha expression in oral squamous cell carcinoma. cells. (2010)
  • Author(s): Sasabe F, Yang T, Ohno S, Yamamoto T.
  • Journal Title: Free Radio Biol Med. 48(10) Pages: 1321-9
  • Peer Reviewed
• [Journal Article] Enhancement of apoptotic damage of squamous cell carcinoma cells by inhibition of the mitochondrial DNA repairing system. (2008)
  • Author(s): Ueta E, Sasabe E, Yang Z, OsakiT, YamamotoT
  • Journal Title: Cancer Sci 99(11) Pages: 2230-7
  • NAID: 10024013145
  • Peer Reviewed
• [Journal Article] Ionizing irradiation induces apoptotic damage of salivary gland acinar cells via NADPH oxidase 1-dependent superoxide generation. (2008)
  • Author(s): Tateishi Y, Sasabe E, Ueta E, Yamamoto T
  • Journal Title: Biochem Biophys Res Commun. 366(2) Pages: 1301-7
  • Peer Reviewed
• [Journal Article] 口腔扁平上皮癌細胞におけるEph/Ephrinの発現とその意義. (2008)
  • Author(s): 笹部衣里, 大野清二, 立本行宏, 山本哲也
  • Journal Title: 口腔組織培養学会誌 17(1) Pages: 41-42
• [Journal Article] Ionizing irradiation induces apoptotic damage of salivary gland acinar cells via NADPH oxidase 1-dependent superoxide generation (2008)
  • Author(s): Tateishi Yoshihisa, Sasabe Eri, Ueta Eisaku, Yamamoto Tetsuya
  • Journal Title: Biochemical and Biophysical Research Communications 366(2) Pages: 301-307
  • Peer Reviewed
• [Presentation] 口腔扁平上皮癌細胞におけるEph/Ephrinシグナルの関わり (2008)
  • Author(s): 大野清二, 笹部衣里, 谷脇史人, 森下慶子, 山本哲也
  • Organizer: 第62回日本口腔科学会学術集会
  • Place of Presentation: 福岡
• [Presentation] 口腔扁平上皮癌細胞におけるEph/Ephrinの発現とその意義 (2007)
  • Author(s): 笹部衣里, 大野清二, 立本行宏, 山本哲也
  • Organizer: 第44回日本口腔組織培養学会
  • Place of Presentation: 愛媛
  • Year and Date: 2007-12-01
• [Presentation] 口腔扁平上皮癌細胞におけるEph/Ephrinの発現とその意義 (2007)
  • Author(s): 笹部衣里、大野清二、立本行宏、山本哲也
  • Organizer: 第44回日本口腔組織培養学会
  • Place of Presentation: 松山市
  • Year and Date: 2007-12-01
• [Remarks]
  • URL: http://www.kochims.ac.jo/~fmdntst/index.hem
• [Remarks]
  • URL: http://www.kochi-ms.ac.jp/~fm_dntst/index.htm