The involvement of Ephrin signaling in the invasion and metastas is of squamous cell carcinoma cells
| Project/Area Number |
19791528
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Surgical dentistry
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| Research Institution | Kochi University |
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Principal Investigator |
SASABE Eri Kochi University, 教育研究部・医療学系, 助教 (40363288)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥5,060,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥660,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2007: ¥2,200,000 (Direct Cost: ¥2,200,000)
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| Keywords | 癌 / 遺伝子 / 細胞 / 組織 / 発現制御 / シグナル伝達 / Eph / Ephrin / 口腔扁平上皮癌 / 浸潤 / 転移 |
|---|
| Research Abstract |
Eph/Ephrin mRNA and protein were expressed in oral squamous cell carcinoma (OSC) cells. EphrinB2 was especially overexpressed in oral squamous cell carcinoma and high invasive OSC cells. The proliferation, attachment, and invasion were suppressed in EphrinB2 knock-downed cells as compared with control cells. The treatment with EphB/Fc chimera promoted the attachment, but inhibited the invasion of EphrinB2 knock-downed cells. these results suggest that EphrinB2 contributes to the proliferation, attachment, and invasion of OSC cells.
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Report
(3 results)
Research Products
(10 results)
