Influence of immunonutrition in oral carcinoma patients receiving chemotherapy

• Project/Area Number: 19791531
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Surgical dentistry
• Research Institution: Nagasaki University
• Principal Investigator: YOSHITOMI Izumi Nagasaki University, 大学院・医歯薬学総合研究科, 助教 (90363457)
• Project Period (FY): 2007 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥3,890,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥690,000); Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2007: ¥900,000 (Direct Cost: ¥900,000)
• Keywords: 臨床腫瘍学 / 免疫栄養 / アルギニン / グルタミン / 口腔癌 / 化学療法

Research Abstract

In this study, I examined the cell proliferation of oral squamous cell carcinoma cell lines with immunonutrients. Furthermore, the cells were exposed to various 5-FU, I examined cytotoxicity and relations with the nutrient density. I examined the expression of OPRT which related to the expression of the side effect and DPD which correlate with drug metabolism.

Research Products

• [Journal Article] Ribonucleotide reductase small subunit p53R2 promotes oral cancer invasion via the E-cadherin/β-catenin pathway (2009)
  • Author(s): Yanamoto, S., Kawasaki, G., Yamada, S., Yoshitomi, I., Yoshida, H., Mizuno, A.
  • Journal Title: Oral Oncology 5 Pages: 521-525
  • Peer Reviewed
• [Journal Article] Overexpression of metastasisassociated MTA1 in oral squamous cell carcinomas : correlation with metastasis and invasion (2008)
  • Author(s): Kawasaki G, Yanamoto S, Yosh itomi I. Yamada S. Mizuno A
  • Journal Title: Int J Oral Maxillofac Surg 37 Pages: 1039-1046
  • Peer Reviewed
• [Presentation] 舌下腺に発生した筋上皮腫の一例. (2009)
  • Author(s): 松谷康平, 川崎五郎, 山田慎一, 吉冨泉, 水野明夫、藤田修一、池田通
  • Organizer: 第42回(NPO)日本口腔科学会九州地方部会
  • Place of Presentation: 久留米市
  • Year and Date: 2009-12-05
• [Presentation] 口腔癌に対するS-1/CDDP併用術前化学療法の効果について. (2009)
  • Author(s): 吉冨泉, 川崎五郎, 柳本惣市, 山田慎一, 水野明夫
  • Organizer: 第47回日本癌治療学会学術集会
  • Place of Presentation: 横浜市
  • Year and Date: 2009-10-23
• [Presentation] 口腔扁平上皮癌におけるEMS1/cortactinの発現の意義 (2009)
  • Author(s): 山田慎一, 柳本惣市, 川崎五郎, 吉冨泉, 川北晃子, 水野明夫
  • Organizer: 第54回(社)日本口腔外科学会総会・学術大会
  • Place of Presentation: 札幌市
  • Year and Date: 2009-10-09
• [Presentation] 口腔癌における癌幹細胞様side population細胞の分離. (2009)
  • Author(s): 柳本惣市, 川崎五郎, 山田慎一, 吉冨泉, 水野明夫
  • Organizer: 第54回(社)日本口腔外科学会総会・学術大会
  • Place of Presentation: 札幌市
  • Year and Date: 2009-10-09
• [Presentation] Efficacy of the S-1/cisplatin preoperative chemotherapy for patients with oral carcinoma. (2009)
  • Author(s): Yoshitomi, I., Kawasaki, G., Yanamoto, S., Yamada, S., Miuzno, A.
  • Organizer: 2nd World Congress of the International Academy of Oral Oncology
  • Place of Presentation: Tronto, Canada
  • Year and Date: 2009-07-10
• [Presentation] Characteristics of cancer stem like side population cell in oral squamous cell carcinoma. (2009)
  • Author(s): Yanamoto, S., Kawasaki, G.,Yamada, S., Yoshitomi, I., Mizuno, A.
  • Organizer: 19th International Conference on Oral and Maxillofacial Surgery
  • Place of Presentation: Shanghai, China
  • Year and Date: 2009-05-24
• [Presentation] Spindle cell carcinoma of the oral cavity. (2009)
  • Author(s): Kawasaki, G., Yanamoto, S., Yoshitomi, I., Kawano, T., Miuzno, A., Fujita, S., Ikeda, T.
  • Organizer: 19th International Conference on Oral and Maxillofacial Surgery
  • Place of Presentation: Shanghai, China
  • Year and Date: 2009-05-24
• [Presentation] 過去10年間の当科における悪性リンパ腫症例の臨床的検討. (2009)
  • Author(s): 吉冨泉, 川崎五郎, 柳本惣市, 馬場信行, 山田慎一, 河野俊広, 水野明夫
  • Organizer: 第63回日本口腔科学会学術集会
  • Place of Presentation: 浜松市
  • Year and Date: 2009-04-17
• [Presentation] 口腔扁平上皮癌におけるEMS1の発現の意義 (2009)
  • Author(s): 山田慎一, 柳本惣市, 川崎五郎, 吉冨泉, 水野明夫
  • Organizer: 第63回日本口腔科学会学術集会
  • Place of Presentation: 浜松市
  • Year and Date: 2009-04-16
• [Presentation] 舌への転移から発見された賢細胞癌の一例 (2008)
  • Author(s): 吉冨泉, 川崎五郎, 吉田一, 水野明夫, 藤田修一, 池田通
  • Organizer: 第41回(NPO)日本口腔科学会九州地方部会
  • Place of Presentation: 北九州市
  • Year and Date: 2008-12-06
• [Presentation] SAPHO症候群と思われたび慢性硬化性下顎骨骨髄炎の1例 (2008)
  • Author(s): 柳本惣市, 川崎五郎, 吉冨泉, 水野明夫
  • Organizer: 第41回(NPO)日本口腔科学会九州地方部会
  • Place of Presentation: 北九州市
  • Year and Date: 2008-12-06
• [Presentation] UFT術前単独投与により原発巣の消失を見た口腔癌症例 (2008)
  • Author(s): 吉冨泉、川崎五郎、山田慎一、柳本惣市、水野明夫
  • Organizer: 第54回(社)日本口腔外科学会総会
  • Place of Presentation: 徳島市
  • Year and Date: 2008-10-20
• [Presentation] 当科における矯正用アンカースクリューインプラントの臨床的検討, 徳島, 10月{日口外誌54(総会特別号), p.162, 2008} (2008)
  • Author(s): 馬場信行, 山田慎一, 吉田一, 柳本惣市, 吉冨泉, 河野俊広, 白石直之, 川崎五郎, 水野明夫
  • Organizer: 第54回(社)日本口腔外科学会総会
  • Place of Presentation: 徳島市
  • Year and Date: 2008-10-20
• [Presentation] 口腔扁平上皮癌におけるactinin4の発現の意義, (福岡市), 2008, 日日本口腔科学会雑誌, 57, 483, 2008 (2008)
  • Author(s): 山田慎一, 柳本惣市, 川崎五郎, 吉冨泉, 水野明夫
  • Organizer: 第62回日本口腔科学会学術集会
  • Place of Presentation: 福岡市
  • Year and Date: 2008-04-17
• [Presentation] Perioperative immunonutrition in patientswith oral carcinoma. (2007)
  • Author(s): Yoshitomi, I., Kawasaki, G., Yanamoto, S., Mizuno, A., Tobita, T., Yamaguchi, T.
  • Organizer: 1st World Congress of the International Academy of Oral Oncology
  • Place of Presentation: Amsterdam, The Netherlands