New Treatment method of Chronic Temporomandibular Joint Arthritis by Ultrasound Gene Translation

• Project/Area Number: 19791538
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Surgical dentistry
• Research Institution: Kyushu Dental College
• Principal Investigator: HABU Manabu Kyushu Dental College, 歯学部, 助教 (00360058)
• Project Period (FY): 2007 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥3,700,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥600,000); Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2008: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2007: ¥1,100,000 (Direct Cost: ¥1,100,000)
• Keywords: 顎関節炎モデル / TNF-α / アポトーシス / 超音波遺伝子導入 / 慢性顎関節炎

Research Abstract

Anti-inflammatory cytokine treatment using ultrasound gene translation is a useful new method for chronic temporomandibular joint arthritis therapy.

Research Products

• [Journal Article] Significance of Dynamic Magnetic Resonance Sialography in Prognostic Evaluation of Saline Solution Irrigation of the Parotid Gland for the Treatment of Xerostomia. (2010)
  • Author(s): Manabu Habu, Tatsuo Tanaka, Taiki Tomoyose, Kentaro Ono, Toshihiro Anzai, Yuu Ozaki, Izumi Yoshioka, Yoshihiro Yamashita, Masaaki Kodama, Noriaki Yamamoto, Masufumi Oda, Nao Wakasugi, Shinobu Matsumoto, Tetsu Takahashi, Kiyotoshi Inenaga, Kazuhiro Tominaga, Yasuhiro Morimoto
  • Journal Title: J Oral Maxillofac Surg Pages: 768-776
• [Journal Article] Significance of Dynamic Magnetic Resonance Sialography in Prognostic Evaluation of Saline Solution Irrigation of the Parotid Gland for the Treatment of Xerostomia. (2010)
  • Author(s): Habu, M., et al
  • Journal Title: J Oral Maxillofac Surg 68 Pages: 768-776
  • Peer Reviewed
• [Journal Article] Targeted drug delivery system for oral cancer therapy using sonoporation. (2009)
  • Author(s): Maeda, H., Tominaga, K., Iwanaga, K., Nagao, F., Habu, M., Tsujisawa, T., Seta, Y., Toyoshima, K., Fukuda, J andNishihara, T
  • Journal Title: J Oral Pathol Med 38(7) Pages: 572-579
• [Journal Article] argeted drug delivery system for oral cancer therapy using sonoporation. (2009)
  • Author(s): Maeda, H., Habu. M., et al
  • Journal Title: J Oral Pathol Med 38 Pages: 572-579
  • Peer Reviewed
• [Journal Article] The BMP signaling and its Smads in Mandibular Distraction Osteogenesis. (2008)
  • Author(s): Khanal, A., Yoshioka, I., Tominaga, K., Furuta, N., Habu, M., Fukuda, J.
  • Journal Title: Oral Diseases 14 Pages: 347-355
• [Journal Article] Influence of altered occlisal plane on rabbit temporomandibular joint cartilage (2008)
  • Author(s): Sakiko. Y.
  • Journal Title: J Oral Pathol Med 1 Pages: 30-37
  • Peer Reviewed
• [Journal Article] The BMP signaling and its Smads in Mandibular Distraction Osteogenesis (2008)
  • Author(s): Khanal. A.
  • Journal Title: Oral Diseases 14 Pages: 347-355
  • Peer Reviewed
• [Journal Article] Local delivery system of cytotoxic agent by sonoporation. (2007)
  • Author(s): Iwanaga, K., Tominaga, K., Yamamoto, K., Habu, M., Maeda, H., Akifusa, S., Tsujusawa, T., Okinaga, T., Fukuda, J., Nishihara, T.
  • Journal Title: Cancer Gene Therapy 14 Pages: 354-363
• [Journal Article] The BMP signaling and its Smads in Mandibular Distraction Osteogenesis. (2007)
  • Author(s): Khanal, A., Yoshioka, I., Tominaga, K., Furuta, N., Habu, M., Fukuda, J.
  • Journal Title: Oral Diseases
• [Journal Article] Changes in temporomandibular disc position during growth in young Japanese. (2007)
  • Author(s): Tominaga, K., Konoo, T., Morimoto, Y., Tanaka, T., Habu, M., Fukuda, J.
  • Journal Title: Dentomaxillofac Radiol 36 Pages: 397-401
• [Journal Article] Influence of altered occlusal plane on rabbit temporomandibular joint cartilage. (2007)
  • Author(s): Yoshikawa, S., Nodai, E., Habu, M., Furuta, N., Fukuda, J., Yamaguti, K.
  • Journal Title: J Oral Pathol Med 37 Pages: 30-37
• [Journal Article] Changes in temporomandibular disc position during growth in young Japanese. (2007)
  • Author(s): Tominaga, K.
  • Journal Title: Dentomaxillofac Radiol 36 Pages: 397-401
  • Peer Reviewed
• [Journal Article] Influence of altered occlusal plane on rabbit temporomandibu lar joint cartilage. (2007)
  • Author(s): Yoshikawa, S.
  • Journal Title: J Oral Pathol Med 37 Pages: 30-37
  • Peer Reviewed
• [Journal Article] Local delivery system of cytotoxic agent by sonoporation. (2007)
  • Author(s): Iwanaga, K.
  • Journal Title: Cancer Gene Therapy 14 Pages: 354-363
  • Peer Reviewed
• [Presentation] ウサギ抗原誘発慢性顎関節炎における抗サイトカイン治療モデルの検討 (2009)
  • Author(s): 土生学, 他
  • Organizer: 第54回日本口腔外科学会総会
  • Place of Presentation: 札幌
  • Year and Date: 2009-10-09
• [Presentation] ウサギ抗原誘発顎関節炎モデルにおける抗サイトカイン治療モデルの検討. (2008)
  • Author(s): 土生学
  • Organizer: 第52回日本口腔外科学会総会
  • Place of Presentation: 徳島
  • Year and Date: 2008-10-22
• [Presentation] ウサギ抗原誘発顎関節炎モデルにおける抗サイトカイン治療モデルの検討 (2008)
  • Author(s): 土生学
  • Organizer: 第52回日本口腔外科学会総会
  • Place of Presentation: 徳島
  • Year and Date: 2008-10-22
• [Presentation] Histopathlogical influence of anti-TNF-alpha therapy on antigen-induced arthritis model of the rabbit temporomandibular joint. (2007)
  • Author(s): Habu, M., Tominaga, K., Hirota, Y., Fukuda, J.
  • Organizer: 89th Annual meeting of the American Assosiation of Oral and Maxillofacial Surgery
  • Place of Presentation: Honolulu, Hawaii, USA
  • Year and Date: 2007-10-17
• [Presentation] Histopathlogical influence of anti-TNF-alpha therapy on antig en-induced arthritis model of the rabbit temporomandibular joint. (2007)
  • Author(s): Habu, M.
  • Organizer: 89th Annual meeting of the American Assosi ation of Oral and Maxillofacial Surgery
  • Place of Presentation: Honolulu,Hawaii,USA
  • Year and Date: 2007-10-17
• [Presentation] ウサギ抗原誘発顎関節炎モデルにおける抗TNF-α抗体顎関節内投与の影響. (2007)
  • Author(s): 土生学
  • Organizer: 第20回日本顎関節学会総会
  • Place of Presentation: 金沢
  • Year and Date: 2007-06-21
• [Presentation] ウサギ抗原誘発顎関節炎モデルにおける抗TNF-α抗体顎関節内投与の影響 (2007)
  • Author(s): 土生 学
  • Organizer: 第20回日本顎関節学会総会
  • Place of Presentation: 金沢
  • Year and Date: 2007-06-21