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Association with central sensitization and descending inhibition in patients with myogenous type of temporomandibular disorder.

Research Project

Project/Area Number 19791542
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Surgical dentistry
Research InstitutionKeio University

Principal Investigator

MURAOKA Wataru  Keio University, 医学部, 共同研究員 (70317254)

Project Period (FY) 2007 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥3,660,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2008: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2007: ¥2,100,000 (Direct Cost: ¥2,100,000)
Keywords歯学 / 遺伝子 / 疼痛 / 慢性筋性顎関節症 / 時間的加重 / セロトニン関連遺伝子
Research Abstract

I hypothesized that the pathogenesis of myogeneous TMD had a relationship to the central sensitization and descending inhibition, and investigated by using temporal summation tests, mapping of referred pain in the masticatory muscle, and the serotonin transporter gene polymorphism.
At the present stage, this study showed that myogeneous TMD cases may, in fact, be related to the central sensitization, and require longer duration of treatment in order to show improvement of signs and symptoms.
The analysis of the serotonin transporter gene polymorphism was, so far, inconclusive. I will continue this study for further consideration by increasing the number of subjects.

Report

(4 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (3 results)

All 2009

All Presentation (3 results)

  • [Presentation] The Difference of Treatment Effectiveness between Active and Latent Myofascial Trigger Point Associated with Temporomandibular Disorder.2009

    • Author(s)
      Wataru Muraoka, Daisuke Kobayashi, Tomoko Wada, Masatsugu Otaishi, Taneaki Nakagawa, Koichi Wajima
    • Organizer
      5th International Conference on Orofacial Pain and Temporomandibular Disorders
    • Place of Presentation
      Brazil Bahia
    • Year and Date
      2009-08-28
    • Related Report
      2009 Final Research Report
  • [Presentation] 筋性顎関節症における活動性トリガーポイントと潜在性トリガーポイントにおける経過の違いについて.2009

    • Author(s)
      村岡渡, 小林大輔, 和田知子, 佐藤仁, 大泰司正嗣, 中川種昭, 和嶋浩一
    • Organizer
      第22回日本顎関節学会総会・学術大会、第14回日本口腔顔面痛学会総会・学術大会共催
    • Place of Presentation
      東京ポスター
    • Year and Date
      2009-07-26
    • Related Report
      2009 Final Research Report
  • [Presentation] The Difference of Treatment Effectiveness between Active and Latent Myofascial Trigger Point Associated with Temporomandibular Disorder2009

    • Author(s)
      Wataru Muraoka
    • Organizer
      5th International Conference on Orofacial Pain and Temporomandibular Disorders
    • Place of Presentation
      Bahia, BRAZIL.
    • Related Report
      2009 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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