Analysis of alterations by stably expressing or suppressing SCCA gene in an oral squamous cell carcinoma cell line

• Project/Area Number: 19791558
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Surgical dentistry
• Research Institution: Fukuoka Dental College
• Principal Investigator: HASHIMOTO Kenichiro Fukuoka Dental College, 歯学部, 助教 (00412619)
• Project Period (FY): 2007 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥3,460,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥360,000); Fiscal Year 2009: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2008: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2007: ¥1,900,000 (Direct Cost: ¥1,900,000)
• Keywords: 臨床腫瘍学 / SCCA / 口腔扁平上皮癌 / 個別化治療法

Research Abstract

This study examined the tumorigenic effect of SCCA (Squamous cell carcinoma antigen) by stably expression or suppuression in an oral squamous cell carcinoma cell line. There was no significant difference in the cellular morphology or proliferative activity, which could have been caused by SCCA transfection, between the SCCA suppressive transfectants and the controls. These results suggested that SCCA do not directly play a role in the cellular morphology or proliferative activity.