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Electrophysiological analysis of higher nervous function induced by orthodontics apparatus

Research Project

Project/Area Number 19791589
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Orthodontic/Pediatric dentistry
Research InstitutionNagasaki University

Principal Investigator

ZEREDO Jorge  Nagasaki University, 大学院・医歯薬学総合研究科, 助教 (10363459)

Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥2,640,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2007: ¥1,600,000 (Direct Cost: ¥1,600,000)
Keywordsストレス / 痛み / 矯正治療 / 行動 / ラット
Research Abstract

ウィスター系ラットを用いて、痛みとストレスの行動学的な解析行った。全身麻酔下で、脳手術にて脳慢性電極を埋め込み、視床下部ニューロン活動の記録した。同時に、咬筋の筋電図を記録した。一群は口腔内にCo-Cr合金からなる矯正装置を切歯部に接着した。この装置は50グラム相当の力を発揮するものであった。もう一群は対照としてシャム装置を接着した。結果として、実験群のラットには装置接着後の一日目に痛みやストレスを示す行動の増大を認めた。拘束に対するストレス応答が増大し、辺縁系を含めた高次機能へのストレスの影響がうかがえる。ラットの臼歯部に矯正力を加えたことによって、摂食行動は低下した。また、咬筋の筋電図活動は高かった。視床下部ニューロンの発火活動は実験群が対照群より低い頻度を認めた。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (18 results)

All 2008 2007 Other

All Journal Article (8 results) (of which Peer Reviewed: 8 results) Presentation (10 results)

  • [Journal Article] Disinhibitory involvement of the anterior cingulate cortex in the descending antinociceptive effect induced by electroacupuncture stimulation in rats2008

    • Author(s)
      Hirano T, Zeredo JL, Kimoto M, Moritaka K, Nasution FH, Toda K
    • Journal Title

      Am J Chin Med 36(3)

      Pages: 569-577

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Emotional stress-and pain-related behaviors evoked by experimental tooth movement2008

    • Author(s)
      Yozgatian JH, Zeredo JL, Hotokezaka H, Koga Y, Toda K, Yoshida N
    • Journal Title

      Angle Orthod 78(3)

      Pages: 487-94

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] A calcium-receptor agonist induces gustatory neural responses in bullfrogs2007

    • Author(s)
      Okada Y, Imendra KG, Miyazaki T, Hotokezaka H, Fujiyama R, Zeredo JL, Toda K
    • Journal Title

      Cell Mol Neurobiol 27(6)

      Pages: 771-781

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Functional changes of the temporomandibular jointmechanoreceptors induced by a lateral mandibular shift in rats2007

    • Author(s)
      Kokai S, Yabushita T, Zeredo JL, Toda K, Soma K
    • Journal Title

      Angle Orthod 77(3)

      Pages: 436-441

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Splenius muscle activities induced by temporomandibular joint stimulation in rats2007

    • Author(s)
      Kobayashi M, Yabushita T, Zeredo JL, Toda K, Soma K
    • Journal Title

      Brain Res Bull 72(1)

      Pages: 44-48

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] High-intensity laser for acupuncture-like stimulation2007

    • Author(s)
      Zeredo JL, Sasaki KM, Toda K
    • Journal Title

      Lasers Med Sci 22(1)

      Pages: 37-41

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effect of traditional "Juci" (contralateral acupuncture) on orofacial nociceptive behavior in the rat2007

    • Author(s)
      Miura K, Ohara T, Zeredo JL, Okada Y, Toda K, Sumikawa K
    • Journal Title

      J Anesth 21(1)

      Pages: 31-36

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Measuring biting behavior induced by acute stress in the rat

    • Author(s)
      Zeredo JL, Kumei Y, Shibazaki T, Yoshida N, Toda K
    • Journal Title

      Behavior Research Methods (in press)

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Presentation] Biting behavior induced by acute stress in the rat during experimental tooth movement2008

    • Author(s)
      ゼレドジョージ
    • Organizer
      行動学測定学会2008
    • Place of Presentation
      マーストリヒト
    • Year and Date
      2008-08-27
    • Related Report
      2008 Annual Research Report
  • [Presentation] レーザー切開による術後痛み感覚とアポトーシスとの関連2008

    • Author(s)
      ゼレド ジョージ
    • Organizer
      アポトーシス2008
    • Place of Presentation
      ルクセンブルグ
    • Year and Date
      2008-01-25
    • Related Report
      2007 Annual Research Report
  • [Presentation] Rat hypothalamic response to the Lunar and Martian gravity during parabolic flights2008

    • Author(s)
      Kumei Y, Zeredo JL, Seki S, Kageyama D, Matsuura M, Fusejima Y, Ikeda T, Toda K
    • Organizer
      Life in Space for Life on Earth 2008 Symposium
    • Place of Presentation
      Angers, Francee
    • Related Report
      2008 Final Research Report
  • [Presentation] Stressful Behaviors During Moderate-Low Gravity Exposure in Rats2008

    • Author(s)
      Zeredo JL, Kumei Y, Toda K
    • Organizer
      Life in Space for Life on Earth 2008 Symposium
    • Place of Presentation
      Angers, France
    • Related Report
      2008 Final Research Report
  • [Presentation] Chemical Sensation can be Modulated by High-Gravity in Rats2008

    • Author(s)
      Kimoto, M. ; Takase, S, Toda, K, Zeredo JL, Kumei, Y
    • Organizer
      Life in Space for Life on Earth 2008 Symposium
    • Place of Presentation
      Angers, France
    • Related Report
      2008 Final Research Report
  • [Presentation] Japanese Research Group for Life Sciences in the Lunar and Martian Gravity2008

    • Author(s)
      Kumei Y, Akiyama H, Ikeda T, Ishioka N, Ito M, Iwasaki K, Igarashi M, Kageyama D, Kizaki M, Matsuura M, Morita S, Mukai C, Nomura Y, Toda K, Wakata K, Yamashita M, Zeredo JL
    • Organizer
      Life in Space for Life on Earth 2008 Symposium
    • Place of Presentation
      Angers, France
    • Related Report
      2008 Final Research Report
  • [Presentation] Measuring the neuronal activity of hypothalamus nd behavior of rats on the diffuse low gravity conditions2008

    • Author(s)
      Kumei Y, Zeredo JL, Seki S, Matsuura M, Kimoto M, Kageyama D, Fusejima Y, Ikeda T, Toda K
    • Organizer
      Measuring Behavior 2008 Symposium
    • Place of Presentation
      Maastricht, The Netherlands
    • Related Report
      2008 Final Research Report
  • [Presentation] Biting behavior induced by acute stress in the rat during experimental tooth movement2008

    • Author(s)
      Zeredo JL, Kumei Y, Shibazaki T, Yoshida N, Kimoto M, Toda K
    • Organizer
      Measuring Behavior 2008 Symposium
    • Place of Presentation
      Maastricht, The Netherlands
    • Related Report
      2008 Final Research Report
  • [Presentation]2008

    • Author(s)
      Kimoto M, Kumei Y, Zeredo JL, Toda K
    • Organizer
      Changes in feeding behavior after high gravity loading in orchidectomized and ovariectomized rats 2008 Symposium
    • Place of Presentation
      Maastricht, The Netherlands
    • Related Report
      2008 Final Research Report
  • [Presentation] ラット針鎮痛発現における前帯状回の役割2007

    • Author(s)
      ゼレド ジョージ
    • Organizer
      日本歯科東洋医学会
    • Place of Presentation
      大阪
    • Year and Date
      2007-10-25
    • Related Report
      2007 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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