Effect of maternal deprivation in the early period on immobilization stress reaction in the adult rat, -the evaluation of a central nervous system mechanism-

• Project/Area Number: 19791591
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Orthodontic/Pediatric dentistry
• Research Institution: Kagoshima University
• Principal Investigator: MATSUMOTO Yuko Kagoshima University, 医学部・歯学部附属病院, 助教 (20315443)
• Project Period (FY): 2007 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥570,000); Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2007: ¥1,300,000 (Direct Cost: ¥1,300,000)
• Keywords: ラット / 母子分離 / 身体抑制ストレス / カテコールアミン作動性ニューロン / 血中コルチコステロン濃度 / カテコールアミン作動陸ニューロン / 6-OHDA

Research Abstract

The immobilization stress-induced corticosterone levels were significantly lower in the MD(6-OHDA) group than in MD(saline) group and control group at T30. Plasma CORT levels were significantly higher in the MD(saline) group than other groups at T180, on the other hand, plasma CORT levels in control group returned to the basal level at T180. In MD(6-OHDA) group, although the peak of plasma CORT levels were low, plasma CORT levels decreased more slowly following termination of stress, and did not return to the basal level at T180. These results suggested that the maternal deprivation in early period produce a long-term effect on the hippocampus of MD rat that was involved in the negative feedback regulation of glucocorticoids.

Research Products

• [Journal Article] Jaw motion during gum-chewing in children with primary dentition. (2010)
  • Author(s): Kubota N, Hayasaki H, Saitoh I, Iwase Y, Maruyama T, Inada E, Hasegawa H, Yamada C, Takemoto Y, Matsumoto Y, Yamasaki Y.
  • Journal Title: The journal of craniomandibular practice 28(1) Pages: 19-29
  • Peer Reviewed
• [Journal Article] Jaw motion during gum-chewing in children with primary dentition. (2010)
  • Author(s): Kubota N, Hayasaki H, Saitoh I, Iwase Y, Maruyama T, Inada E, Hasegawa H, Yamada C, Takemoto Y, Matsumoto Y, Yamasaki Y.
  • Journal Title: The journal of cranio mandibular practice 28(1) Pages: 19-29
  • Peer Reviewed
• [Journal Article] Movement of the instantaneous center of rotation and the position of the lateral excursion center during lateral excursion. (2008)
  • Author(s): Hayasaki H, Saitoh I, Iwase Y, Inada E, Hasegawa H, Tokutomi J, Matsumoto Y, Yamasaki Y.
  • Journal Title: The journal of craniomandibular practice 26(4) Pages: 253-262
  • Peer Reviewed
• [Journal Article] Cross-sectional growth changes in skeletal and soft tissue cephalometric landmarks of children. (2008)
  • Author(s): Inada E, Saitoh I, Hayasaki H, Yamada C, Iwase Y, Takemoto Y, Matsumoto Y, Yamasaki Y.
  • Journal Title: The journal of craniomandibular practice 26(3) Pages: 170-181
  • Peer Reviewed
• [Journal Article] Cross-sectional growth changes in skeletal and soft tissue cephalometric landmarks of children (2008)
  • Author(s): Inada E, Saitoh I, Hayasaki H, Yamada C, Iwase Y, T akemoto Y, Matsumoto Y, Yamasaki Y.
  • Journal Title: the journal of craniomandibular practice 26(3) Pages: 170-181
  • Peer Reviewed
• [Journal Article] Movement of the instantaneous center of rotation and the position of the lateral excursion center during lateral excursion (2008)
  • Author(s): Hayasaki H, Saitoh I, Iwase Y, Inada E, Hasegawa H, Tokutomi J, Matsumoto Y, Yamasaki Y.
  • Journal Title: the journal of craniomandibular practice 26(4) Pages: 253-262
  • Peer Reviewed