Exploring the possibility of the fibrinogen gene polymorphism as a prepotent risk factor of pathogenesis of periodontitis

• Project/Area Number: 19791607
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Periodontal dentistry
• Research Institution: Niigata University
• Principal Investigator: MOROZUMI Toshiya Niigata University, 医歯学総合病院, 助教 (20444151)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥3,550,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥450,000); Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2007: ¥1,600,000 (Direct Cost: ¥1,600,000)
• Keywords: フィブリノゲン / 遺伝子多型 / Bβフィブリノゲン / プロモーター領域 / IL-6 / 遺伝子機能解析

Research Abstract

フィブリノゲンは急性炎症時の血液凝固・止血反応において重要な機能を果たす蛋白質として知られる。高濃度フィブリノゲンは過度の血栓形成や出血傾向をもたらし、冠状動脈性心疾患や脳梗塞に対する有意な独立した危険因子となる。Bβフィブリノゲン・プロモーター領域には6つの遺伝子多型が存在するが、実際にどの多型が機能を有しているのかはわかっていない。そこで全ての組み合わせを作製し、同時に機能解析を行った。その結果、-1420G/A と-148C/Tがサプレッサーとして、-854G/Aがエンハンサーとしての機能を有することが示唆された。

Research Products

• [Journal Article] A case report of multiple-drug-induced gingival overgrowth with TIMP-3 over-expression (2008)
  • Author(s): Kubota T, Itagaki M, Morozumi T, Maruyama S, Nakasone N, Shimizu T, Saku T, Yoshie H
  • Journal Title: Oral Medicine & Pathology 12 Pages: 141-148
  • NAID: 130004509511
  • Peer Reviewed
• [Journal Article] Altered gene expression levels of matrix metalloproteinases and their inhibitors in periodontitis-affected gingival tissue (2008)
  • Author(s): Kubota T, Itagaki M, Hoshino C, Nagata M, Morozumi T, Kobayashi T, Takagi R, Yoshie H
  • Journal Title: Journal of Periodontology 79 Pages: 166-173
  • Peer Reviewed
• [Journal Article] Altered gene expression levels of matrix metalloproteinases and theirinhibitors in periodontitis-affected gingival tissue. (2008)
  • Author(s): Kubota T, Itagaki M, Hoshino C, Nagata M, Morozumi T, Kobayashi T, Takagi R, Yoshie H
  • Journal Title: Journal of Periodontology 79 Pages: 166-173
  • Peer Reviewed
• [Journal Article] The functional effects of the -455G/A polymorphism on the IL-6-induced expression of the β-fibrinogen gene may be due to linkage disequilibrium with other functional polymorphisms
  • Author(s): Morozumi T, Sharma A, De Nardin E
  • Journal Title: Immunological Investigations (in press)
  • Peer Reviewed
• [Journal Article] The functional effects of the -455G/A polymorphism on the IL-6-induced expression of the β-fibrinogen gene may be due to linkage disequilibrium with other functional polymorphisms
  • Author(s): Morozumi T, Sharma A, De Nardin E
  • Journal Title: Immunological Investigations (in press)
  • Peer Reviewed
• [Presentation] Effects of subgingival irrigation and rinsing with an essential oil-containing antimicrobial mouthrinse and administration of azithromycin on bacteremia due to scaling and root planning (2008)
  • Author(s): Morozumi T, Abe D, Shimizu T, Kubota T, Yoshie H
  • Organizer: The 94th Annual Meeting of the AAP
  • Place of Presentation: Seattle, U.S.A
• [Presentation] The gene expression profile in sites with drug-induced gingival overgrowth or periodontitis-affected tissues (2008)
  • Author(s): Kubota T, Shimizu T, Abe D, Morozumi T, Yoshie H
  • Organizer: The 94th Annual Meeting of the AAP
  • Place of Presentation: Seattle, U.S.A
• [Presentation] Effects of subgingival irrigation and rinsing with an essential oil-containing antimicrobial mouthrinse and administration of azithromycin on bacteremiadue to scaling and root planning (2008)
  • Author(s): Morozumi T, Abe D, Shimizu T, Kubota T, Yoshie H
  • Organizer: The 94th Annual Meeting of the AAP
  • Place of Presentation: 米国、シアトル、ワシントン州立コンベンション・貿易センター
• [Presentation] The gene expression profile in sites with drug-induced gingival overgrowthor periodontitis-affected tissues (2008)
  • Author(s): Kubota T, Shimizu T, Abe D, Morozumi T, Yoshie H
  • Organizer: The 94th Annual Meeting of the AAP
  • Place of Presentation: 米国、シアトル、ワシントン州立コンベンション・貿易センター
• [Presentation] IL-6誘導によるBβフィブリノゲン・プロモーター領域遺伝子多型における転写活性の変化. (2007)
  • Author(s): 両角俊哉、吉江弘正
  • Organizer: 第49回歯科基礎医学会総会
  • Place of Presentation: 札幌・北海道大学
  • Year and Date: 2007-08-30
• [Presentation] Altered MMP/TIMP gene expression in drug-induced gingival overgrowth patients'gingivae (2007)
  • Author(s): Kubota T, Hoshino C, Itagaki M, Morozumi T, Nohno K, Yoshie H
  • Organizer: The 37th SSP annual meeting in conjunction with the 11th IAP Biennial Congress
  • Place of Presentation: Berne, Switzerland
• [Presentation] Functional effects of gene polymorphisms in the β-fibrinogen promoter region (2007)
  • Author(s): Morozumi T, Sharma A, Kubota T, Yoshie H, De Nardin E
  • Organizer: The 37th SSP annual meeting in conjunction with the 11th IAP Biennial Congress
  • Place of Presentation: Berne, Switzerland
• [Presentation] IL-6 誘導によるBβフィブリノゲン・プロモーター領域遺伝子多型における転写活性の変化 (2007)
  • Author(s): 両角俊哉、吉江弘正
  • Organizer: 第49回歯科基礎医学会総会, (Journal of Oral Biosciences vol.49 Suppl., 2007)
  • Place of Presentation: 札幌
• [Presentation] Functional effects of gene polymorphisms in the β-fibrinogen promoter region. (2007)
  • Author(s): Morozumi T, Sharma A, Kubota T, Yoshie H, De Nardin E
  • Organizer: The 37th SSP annual meeting in conjunction with the 11th IAP Biennial Congress
  • Place of Presentation: スイス連邦・ベルン・アレグロ国際会議場
• [Presentation] Altered MMP/TIMP gene expression in drug-induced gingival overgrowth patients's gingivae. (2007)
  • Author(s): Kubota T, Hoshino C, Itagaki M, Morozumi T, Nohno K, Yoshie H
  • Organizer: The 37th SSP annual meeting in conjunction with the 11th IAP Biennial Congress
  • Place of Presentation: スイス連邦・ベルン・アレグロ国際会議場