Analysis of novel inflammatory mediator HMGB1in periodontitis

• Project/Area Number: 19791618
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Periodontal dentistry
• Research Institution: Kagoshima University
• Principal Investigator: MORIMOTO Youko Kagoshima University, 医学部・歯学部附属病院, 助教 (30437967)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥3,680,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥480,000); Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2007: ¥1,600,000 (Direct Cost: ¥1,600,000)
• Keywords: HMGB1 / Ca9-22 / 歯周病 / TNF-α / IL-8 / MAPK / ERK / 歯肉上皮細胞 / P38MAPK

Research Abstract

炎症の新規メディエーターであるHMGB1は歯周病罹患歯肉では歯肉上皮細胞の細胞質に局在が認められ、TNF-α刺激によって細胞外へ放出されることが認められた。そして歯肉上皮上皮細胞からの放出経路はp38MAPKを介することが確認できた。また、HMGB1で歯肉上皮細胞を刺激するとIL-8の産生が上昇することから、歯周病局所におけるHMGB1の放出は、炎症性細胞の浸潤に関わっている可能性があることが示唆された。

Research Products

• [Journal Article] Induction of high mobility group box 1 release from serotonin-stimulated human umbilical vein endothelial cells (2008)
  • Author(s): Ko-Ichi Kawahara, Teruto Hashiguchi, Kiyoshi Kikuchi, Salunya Tancharoen, Naoki Miura, Takashi Ito, Yoko Oyama, Yuko Nawa, Kamal K. Biswas, Meng Xiao Jie, Yoko Morimoto, Binita Srestha, Hisayo Samashima, Ikuro Maruyama
  • Journal Title: International Journal of Molecular Medicine 22 Pages: 639-644
  • Peer Reviewed
• [Journal Article] C-reactive protein induces high-mobility group box-1 protein release through activation of p38MAPK in macrophage RAW264. 7 cells (2008)
  • Author(s): Kawahara K, Biswas KK, Unoshima M, Ito T, Kikuchi K, Morimoto Y, Iwata M, Tancharoen S, Oyama Y, Takenouchi K, Nawa Y, Arimura N, Jie MX, Shrestha B, Miura N, Shimizu T, Mera K, Arimura S, Taniguchi N, Iwasaka H, Takao S, Hashiguchi T, Maruyama I
  • Journal Title: Cardiovascular Pathology 17 Pages: 139-138
  • Peer Reviewed
• [Journal Article] Tumor necrosis factor-α Stimulates Gingival Epithelial Cells to Release High-Mobility-Group Box 1 (2008)
  • Author(s): Morimoto Y, Kawahara KI, Tanchareon S, Kikuchi K, Matsuyama T, Hashiguchi T, Izumi Y, Maruyama I
  • Journal Title: Journal of Periodontal Research 43 Pages: 76-83
  • Peer Reviewed
• [Journal Article] Induction of high mobility group box 1 release from serotonin-stimulated human umbilical vein endothelial cells (2008)
  • Author(s): Kawahara K, Morimoto Y, Maruyama I., et.al.
  • Journal Title: International Journal of Molecular Medicine 22 Pages: 639-644
  • Peer Reviewed
• [Journal Article] C-reactive protein induces high-mobility group box-1 prote in release through activation of p38MAPK in macrophage RAW264.7 cells (2008)
  • Author(s): Kawahara K, Morimoto Y, Maruyama I., et.al.
  • Journal Title: Cardiovascular Pathology 17 Pages: 129-138
  • Peer Reviewed
• [Journal Article] Tumor necrosis factor-a Stimulates Gingival, Epithelial Cells to Release High-Mobility-Group Box 1 (2008)
  • Author(s): Yoko Morimoto, Ko-ichi Kawahara, Maruvama I., et.al.
  • Journal Title: Journal of Periodontal Research 43 Pages: 76-83
  • Peer Reviewed
• [Presentation] ヒト歯肉上皮細胞のIL-8産生に及ぼすHigh Mobility Group Box 1(HMGB1)の影響 (2008)
  • Author(s): 森元陽子、川原幸一、菊池清志、松山孝司、中島結実子、小薗清香、町頭三保、丸山征郎、和泉雄一
  • Organizer: 日本歯周病学会50周年記念大会
  • Place of Presentation: 東京
  • Year and Date: 2008-09-21
• [Presentation] Gingival Epithelial Cells Potently Release HMGB1 : Implication in Periodontitis (2008)
  • Author(s): Yoko Morimoto, Ko-ichi Kawahara, Kiyoshi Kikuchi, Salunya Tancharoen, Takashi Matsuyama, Yuichi Izumi, Ikuro Maruyama, Kazuyuki Noguchi
  • Organizer: 86 IADR
  • Place of Presentation: カナダ、トロント
  • Year and Date: 2008-07-04
• [Presentation] Gingival Epithelial Cells Potently Release HMGB1 : Implication in Periodontitis (2008)
  • Author(s): Yoko Morimoto, Ko-ichi Kawa hara, Kazuyuki Noguchi, et.al.
  • Organizer: #86 IADR
  • Place of Presentation: カナダ(トロント)
  • Year and Date: 2008-07-02
• [Presentation] ヒト歯肉上皮細胞のIL-8産生に及ぼすHigy Mobility Group Box 1 (HMGBl)の影響 (2007)
  • Author(s): ○森元陽子、川原幸一、菊池清志、松山孝司、中島結実子、小薗清香、町順三保、丸山征郎、和泉雄一
  • Organizer: 第50回秋季日本歯周病学会学術大会
  • Place of Presentation: 東京
  • Year and Date: 2007-09-21