| Project/Area Number |
19791629
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Social dentistry
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| Research Institution | Tohoku University |
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Principal Investigator |
OHI Takashi Tohoku University, 大学院・歯学研究科, 助教 (10396450)
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| Co-Investigator(Renkei-kenkyūsha) |
MIYOSHI Yoshitada 東北大学, 大学病院, 医員 (10508948)
ITABASHI Shiho 東北大学, 大学院・歯学研究科, 大学院非常勤講師 (80451607)
MURAKAMI Takahisa 東北大学, 大学院・歯学研究科, 大学院非常勤講師 (70451606)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥3,830,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥630,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2007: ¥1,100,000 (Direct Cost: ¥1,100,000)
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| Keywords | 疫学 / 歯周病 / 無症候性脳血管障害 / ラクナ梗塞 / 白質病変 / 一般住民 / 疫学研究 / 大迫研究 / MRI / パノラマエックス線 |
|---|
| Research Abstract |
The purpose of this cross-sectional cohort study was to examine the association between periodontal disease and silent cerebrovascular lesions. The study cohort comprised 230 individuals at least 55 years of age residing in Ohasama, rural community in northern Japan. Subjects underwent periodontal examination and were classified into 4 groups depending on the periodontal and dentate status (normal/slight, moderate and severe peirodontitis and <10 teeth group). The association between periodontal disease and silent cerebrovascular lesions (white matter hyperintensity and lacunar infarcts) was explored by multivariate logistic regression analysis adjusted for age; gender; body mass index; smoking; alcohol consumption; and a history of hypertension, diabetes, and hypercholesterolemia. The proportions of individuals with silent cerebrovascular lesions gradually increased with a severer periodontal status. The odds ratio for the presence of lacunar infarct in severe periodontal status (OR=12.6) was significantly higher than that in the nomal/slight periodontal status (Reference). This result suggests that periodontal disease may be associated with an increased risk of silent cerebrovascular lesions.
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