Investigation on the association between periodontal disease and silent cerebrovascular lesions in a community-dwelling population.
| Project/Area Number |
19791629
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Social dentistry
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| Research Institution | Tohoku University |
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Principal Investigator |
OHI Takashi Tohoku University, 大学院・歯学研究科, 助教 (10396450)
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| Co-Investigator(Renkei-kenkyūsha) |
MIYOSHI Yoshitada 東北大学, 大学病院, 医員 (10508948)
ITABASHI Shiho 東北大学, 大学院・歯学研究科, 大学院非常勤講師 (80451607)
MURAKAMI Takahisa 東北大学, 大学院・歯学研究科, 大学院非常勤講師 (70451606)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥3,830,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥630,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2007: ¥1,100,000 (Direct Cost: ¥1,100,000)
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| Keywords | 疫学 / 歯周病 / 無症候性脳血管障害 / ラクナ梗塞 / 白質病変 / 一般住民 / 疫学研究 / 大迫研究 / MRI / パノラマエックス線 |
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| Research Abstract |
The purpose of this cross-sectional cohort study was to examine the association between periodontal disease and silent cerebrovascular lesions. The study cohort comprised 230 individuals at least 55 years of age residing in Ohasama, rural community in northern Japan. Subjects underwent periodontal examination and were classified into 4 groups depending on the periodontal and dentate status (normal/slight, moderate and severe peirodontitis and <10 teeth group). The association between periodontal disease and silent cerebrovascular lesions (white matter hyperintensity and lacunar infarcts) was explored by multivariate logistic regression analysis adjusted for age; gender; body mass index; smoking; alcohol consumption; and a history of hypertension, diabetes, and hypercholesterolemia. The proportions of individuals with silent cerebrovascular lesions gradually increased with a severer periodontal status. The odds ratio for the presence of lacunar infarct in severe periodontal status (OR=12.6) was significantly higher than that in the nomal/slight periodontal status (Reference). This result suggests that periodontal disease may be associated with an increased risk of silent cerebrovascular lesions.
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Report
(4 results)
Research Products
(19 results)
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[Journal Article] 中高齢者の抑うつに関わる歯科的要因:大迫研究.2008
Author(s)
大井孝, 栗本鮎美, 板橋志保, 三好慶忠, 水戸祐子, 水尻大希, 服部佳功, 伊藤理恵, 鈴木和広, 細川彩, 平野幹雄, 大久保孝義, 細川徹, 粟田主一, 今井潤, 渡邉誠
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Journal Title
老年歯科医学 23巻3号
Pages: 308-318
NAID
Related Report
Peer Reviewed
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[Journal Article] 中高齢者の抑うつに関わる歯科的要因 : 大迫研究2008
Author(s)
大井孝, 栗本鮎美, 板橋志保, 三好慶忠, 水戸祐子, 水尻大希, 服部佳功, 伊藤理恵, 鈴木和広, 細川彩, 平野幹雄, 大久保孝義, 細川徹, 粟田主一, 今井潤, 渡邉誠
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Journal Title
NAID
Related Report
Peer Reviewed
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[Presentation] Association of Periodontal Disease with Atherosclerosis: the Ohasama Study.2009
Author(s)
S Itabashi, T Ohi, T Murakami, H Mizushiri, M Kikuya, T Ohkubo, J Hashimoto, Y Imai, M Watanabe
Organizer
87th General Session & Exhibition of the IADR
Place of Presentation
Miami, Florida, USA
Related Report
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[Presentation] 咬合支持・咬合力と転倒骨抗発生との関運2008
Author(s)
大井孝, 服部佳功, 坪井明人, 佐藤智昭, 伊藤進太郎, 小牧健一朗, 土谷昌広, 山口哲史, 水戸祐子, 菊池雅彦, 辻一郎, 渡邉誠
Organizer
第117回日本補綴歯科学会学術大会
Place of Presentation
名古屋
Year and Date
2008-06-07
Related Report
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[Presentation] 地域高齢者における口腔状態と精神機能の縦断的検討2007
Author(s)
西村一将, 高津匡樹, 大井 孝, 菊池雅彦, 玉澤佳純, 服部佳功, 坪井明人, 佐藤智昭, 岩松正明, 伊藤進太郎, 小牧健一朗, 土谷昌広, 山口哲史, 大森 芳, 辻 一郎, 渡邉 誠
Organizer
第18回日本老年歯科医学会
Place of Presentation
札幌
Year and Date
2007-06-21
Related Report
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