Study of IGF-I effect on anti-aging for the jawbone and masticatory muscles

• Project/Area Number: 19791631
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Social dentistry
• Research Institution: Tohoku University
• Principal Investigator: KOJIMA Ikuho Tohoku University, 病院, 医員 (80447169)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥2,040,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥240,000); Fiscal Year 2008: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2007: ¥1,000,000 (Direct Cost: ¥1,000,000)
• Keywords: IGF-I / 下顎骨 / 舌 / 下顎頭 / 軟骨性成長

Research Abstract

ラットへのIGF-Iの持続投与により、下顎骨は歯列弓の幅が大きくなり、舌は舌体部重量が増加し、組織学的に筋線維束の幅および細胞間隙、上皮の厚さが増大していることが明らかとなった。この舌肥大が、下顎骨の形態学的変化をひき起こしていることが示唆された。さらに、下顎頭の軟骨層の厚さおよび骨基質面積比、骨芽細胞数が増大していることがあきらかとなり、下顎骨の過成長は、下顎頭における軟骨性成長の促進によりひき起こされていることが示唆された。

Research Products

• [Journal Article] High serum levels of IGF-I contribute to promotion of endochondral ossification in mandibular condyle and cause its specific elongation in acromegaly-like rats (2008)
  • Author(s): Kojima I, Iikubo M, Kobayashi A, Ikeda H, Sakamoto M, Sasano T.
  • Journal Title: Horm Metab Res 40 Pages: 533-538
  • Peer Reviewed
• [Journal Article] Excessive Lateral Dental Arch Expansion in Experimentally Developed Acromegaly-like Rats (2008)
  • Author(s): Iikubo M, Kobayashi A, Kojima I, Ikeda H, Sakamoto M, Sasano T.
  • Journal Title: Arch Oral Biol 53(10) Pages: 924-927
  • Peer Reviewed
• [Journal Article] Excessive Lateral Dental Arch Expansion in Experimentally Developed Acromegaly-like Rats. Arch Oral Biol (2008)
  • Author(s): Iikubo Masahiro, Kojima Ikuho, et.al.
  • Journal Title: Archives of Oral Biology 53(10) Pages: 924-927
  • Peer Reviewed
• [Journal Article] High Serum Levels of IGF-I Contribute to Promotion of Endochondoral Ossification in Mndibular Condyle and Cause its Specific Elongation in Acromegalv-like Rats (2008)
  • Author(s): Kojima Ikuho et.al.
  • Journal Title: Hormone and Metabolic Research 40 Pages: 533-538
  • Peer Reviewed
• [Journal Article] High Serum Levels of IGF-I Contribute to Promotion of Endochondoral Ossification in Mndibular Condyle and Cause its Specific Elongation in Acromegaly-like Rats (2008)
  • Author(s): Kojima Ikuho et. al.
  • Journal Title: Hormone and Metabolic Research (In press)
  • Peer Reviewed
• [Presentation] Histomorphologic Changes in the Mandibular Condyle of Acromegaly-like Rats (2008)
  • Author(s): Kojima I, Iikubo M, Kobayashi A, Ikeda H, Sakamoto M, Sasano T.
  • Organizer: IADR 86th General Session & Exhibition
  • Place of Presentation: Toronto
  • Year and Date: 2008-07-04
• [Presentation] Histomorphologic Changes in the Mandibular Condyle of Acromegaly-like Rats (2008)
  • Author(s): Kojima Ikuho et.al.
  • Organizer: IADR 86th General Session & Exhibition
  • Place of Presentation: Tbronto (カナダ)
  • Year and Date: 2008-07-04
• [Presentation] 末端肥大症様ラットモデルにおける下顎頭過成長の組織学的変化 (2008)
  • Author(s): 小嶋郁穂、飯久保正弘、阪本真弥、池田秀敏、笹野高嗣
  • Organizer: 第5回バイオサイエンスシンポジウム
  • Place of Presentation: 仙台
  • Year and Date: 2008-05-19
• [Presentation] 末端肥大症様ラットモデルにおける下顎頭過成長の組織学的変化 (2008)
  • Author(s): 小嶋郁穂、他
  • Organizer: 第5回バイオサイエンスシンボジウム
  • Place of Presentation: 仙台
  • Year and Date: 2008-05-12
• [Presentation] 末端肥大症様ラットモデルにおける顎・口腔組織の動的変化に関する研究-下顎頭の形態学的変化および組織学的変化について- (2007)
  • Author(s): 小嶋郁穂、飯久保正弘、小林あかね、池田秀敏、阪本真弥、笹野高嗣
  • Organizer: 第3回アクロメガリー・フォーラム
  • Place of Presentation: 東京
  • Year and Date: 2007-10-06
• [Presentation] 末端肥大症様ラットモデルにおける顎・口腔組織の動的変化に関する研究 (2007)
  • Author(s): 小嶋 郁穂, 他
  • Organizer: 第3回アクロメガリーフォーラム
  • Place of Presentation: 東京
  • Year and Date: 2007-10-06
• [Presentation] High Serum Levels of IGF-I Contribute to Promotion of Endochondoral Ossification in Mndibular Condyle and Cause its Specific Elongation in Acromegaly-like Rats (2007)
  • Author(s): Kojima Ikuho et. al.
  • Organizer: International Congress of DentoMaxilloFacial Radiology
  • Place of Presentation: Beijing