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Dynamic Pathway Prediction by Signature Analysisusing Multiple Edge

Research Project

Project/Area Number 19800009
Research Category

Grant-in-Aid for Young Scientists (Start-up)

Allocation TypeSingle-year Grants
Research Field Bioinformatics/Life informatics
Research InstitutionThe University of Tokyo

Principal Investigator

OHTA Yoshihiro  The University of Tokyo, 先端科学技術研究センター, 特任研究員 (80436592)

Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥322,000 (Direct Cost: ¥280,000、Indirect Cost: ¥42,000)
Fiscal Year 2008: ¥182,000 (Direct Cost: ¥140,000、Indirect Cost: ¥42,000)
Fiscal Year 2007: ¥140,000 (Direct Cost: ¥140,000)
Keywordsマルチプルエッジ / シグネチャ解析 / シグネチャパスウェイ / ハブ遺伝子 / シグネチャ / テキストマイニング / パスウェイ / ネットワーク
Research Abstract

生物系公開データベースと文献情報から時間的・空間的に関連の深いパスウェイを高精度に抽出する研究を行った。また、属性となる情報を取得し、関係の近いパスウェイをクラスタリングすることで、高精度で網羅性の高いシグネチャパスウェイ知識ベースの構築を可能とした。さらに、ここで構築された知識ベースを用いて、発現データを入力とし変動しているパスウェイを自動的に同定するための予測実験を行った。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (5 results)

All 2008 2007 Other

All Presentation (4 results) Remarks (1 results)

  • [Presentation] MultipleSnapshots Obtained Using Genomic TilingArrays Reveal the Dynamics ofTranscription in Human UmbilicalEndothelial Cells2008

    • Author(s)
      Tatsuhiko Kodama, Yoshihiro Ohta, MengXu, Takashi Minami1, Youichiro Wada, Shu-ichi Tsutsumi, Shumpei Ishikawa,Takao HamakuboHiroyuki Aburatani, PeterR Cook, and Sigeo Ihara
    • Place of Presentation
      SydneyAustralia
    • Related Report
      2008 Final Research Report
  • [Presentation] High-resolution targetedproteomics of endogenousnuclear receptorcomprex using high-quality immunomagneticbeads2007

    • Author(s)
      Kenji Daigo, Takeshi Kawamura, SatoshiKatayose, Yoshihiro Ohta, Toshiya Tanaka, Sigeo Ihara, Tatsuhiko Kodama, TakaoHamakubo
    • Organizer
      Cold Spring Harbor LaboratoryMechanisms of Eukaryotic Transcriptionmeeting
    • Place of Presentation
      cold Spring Harbor, NY.
    • Year and Date
      2007-08-31
    • Related Report
      2008 Final Research Report
  • [Presentation] Robustness of the proteininteraction network2007

    • Author(s)
      Nobuhiko Oshida, Jun-ichi Kitakami, Naoko S. Nishikawa, Yoshihiro Ohta, and Sigeo Ihara
    • Organizer
      The 7thinternational workshop on advancedgenomics
    • Place of Presentation
      Tokyo, Japan
    • Related Report
      2008 Final Research Report
  • [Presentation] Robustness of the protein interaction network.2007

    • Author(s)
      Nobuhiko Oshida, Jun-ichi Kitakami, Naoko S. Nishikawa, Yoshihiro Ohta, and Sigeo Ihara and Sigeo Ihara
    • Organizer
      The 7th international workshop on advanced genomics.
    • Place of Presentation
      Tokyo, Japan.
    • Related Report
      2007 Annual Research Report
  • [Remarks]

    • URL

      http://www.lsbm.org/

    • Related Report
      2008 Annual Research Report

URL: 

Published: 2007-04-01   Modified: 2016-04-21  

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