Electret β-TCP particle composited chitosan tube for peripheral nerve regeneration

• Project/Area Number: 19800011
• Research Category: Grant-in-Aid for Young Scientists (Start-up)
• Allocation Type: Single-year Grants
• Research Field: Biomedical engineering/Biological material science
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: OU Gi Tokyo Medical and Dental University, 生体材料工学研究所, 研究機関研究員 (60451944)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥3,075,000 (Direct Cost: ¥2,670,000、Indirect Cost: ¥405,000); Fiscal Year 2008: ¥1,755,000 (Direct Cost: ¥1,350,000、Indirect Cost: ¥405,000); Fiscal Year 2007: ¥1,320,000 (Direct Cost: ¥1,320,000)
• Keywords: 再生医工学材料 / β-TCP / 電気分極 / キトサン / 神経再生 / 末梢神経 / 生体材料 / ナノスケフォルド / バイオセラミック / 電気分極処理

Research Abstract

電気分極β-TCP微粒子をキトサン繊維多孔体チューブの外層に固定し複合神経架橋用チューブを作製した。ラットの坐骨神経モデルを用いて神経移植材としての有効性を検討した。自家神経移植に相当する再生結果が得られた。

Research Products

• [Journal Article] Comparison of enhancement of bone ingrowth into hydroxyapatite ceramics with highly and lowly intereonnected pores by Electrical Polarization (2009)
  • Author(s): Wang W., Itoh S., et.
  • Journal Title: Acta Biomaterialia (In press)
  • Peer Reviewed
• [Journal Article] Influences of Mechanical Properties and Permeability on Chitosan Nano/microfiber Mesh Tubes as a Scaffold for Nerve Regeneration (2008)
  • Author(s): Wang W., Itoh S., Matsuda A., Ichinose S., Shinomiya K., Hata Y., Tanaka J.
  • Journal Title: J.Biomed.Mater.Res.Part A Vol84 Pages: 557-566
• [Journal Article] Influences of Mechanical Properties and Permeability on Chitosan Nano/microfiber Mesh Tubes as a Scaffold for Nerve Regeneration (2008)
  • Author(s): Wang W., Itoh S., et.
  • Journal Title: J. Biomed. Mater. Res. Part A 84 Pages: 557-566
  • Peer Reviewed
• [Journal Article] Effects of Schwann cell alignment along the oriented electrospun chitosan nanofibers on nerve regeneration (2008)
  • Author(s): Wang W., Itoh S., et.
  • Journal Title: J. Biomed. Mater. Res. Part A. (In press)
  • Peer Reviewed
• [Journal Article] Enhanced nerve regeneration through a bilayered chitosan tube: The effect of introduction of glycine spacer into the CYIGSR sequence (2008)
  • Author(s): Wang W., Itoh S., Matsuda A., Aizawa T., Demura M., Ichinose S., Shinomiya K., Tanaka J.
  • Journal Title: J. Biomed. Mater. Res 85 Pages: 919-928
  • Peer Reviewed
• [Journal Article] Influences of Mechanical Properties and Permeability on Chitosan Nano/microfiber Mesh Tubes as a Scaffold for Nerve Regeneration (2008)
  • Author(s): Wang W., Itoh S., Matsuda A., Ichinose S., Shinomiya K., Hato Y., Tanaka J.
  • Journal Title: J. Biomed. Mater. Res 84 Pages: 557-566
  • Peer Reviewed
• [Journal Article] Regeneration of Peripheral Nerves by Bioabsorbable Polymer Tubes with Fibrin Gel (2007)
  • Author(s): Nakayama K., Takakuda K., Koyama Y., Itoh S., Wang W., Shirahama N., Mukai T.
  • Journal Title: J. Nanosci. Nanotechnol. 7 Pages: 730-733
  • Peer Reviewed
• [Journal Article] Enhancement of peripheral nerve regeneration by using bioabsorbable polymer tubes packed with fibrin gel (2007)
  • Author(s): Nakayama K., Takakuda K., Koyama Y., Itoh S., Wang W., Mukai T., Shirahama N.
  • Journal Title: Artif. Organs 31 Pages: 500-508
  • Peer Reviewed
• [Journal Article] Electrical Polarization Processing Improves Bone Regeneration in Interconnected Pores of Porous HA (2007)
  • Author(s): Yamashita K., Itoh S., Wang W.
  • Journal Title: Orthopaedic Ceramic Implants 26 Pages: 34-39
  • Peer Reviewed
• [Journal Article] Electrical Polarized Hydroxyapatite Ceramics Induced Super Osteoconductivity (2007)
  • Author(s): Wang W., Itoh S., Tanaka Y., Yamashita K.
  • Journal Title: Annual Reports of the Institute of Biomaterials and Bioengineering 41 Pages: 22-25
  • NAID: 40016136070
• [Journal Article] Effects of Schwann cell alignment alongthe oriented electrospun chitosan nanofibers on nerve regeneration
  • Author(s): Wei Wang, Soichiro Itoh, Katsumi Konno, Takeshi Kikkawa, Shizuko Ichinose, Katsuyoshi Sakai, Tsuneo Ohkuma, Kazuhiko Watabe
  • Journal Title: J.Biomed.Mater.Res.Part A (In press)
• [Journal Article] Comparison of enhancement of bone ingrowth into hydroxyapatite ceramics with highly and lowly interconnected pores by Electrical Polarization
  • Author(s): Wei Wang, Soichiro Itoh, Yumi Tanaka, Akiko Nagai, Kimihiro Yamashita
  • Journal Title: Acta Biomaterialia (In press)
• [Presentation] 分極β-TCP粉体を用いた末梢神経再生 (2009)
  • Organizer: 日本セラミック協会2009年年会
  • Place of Presentation: 野田
• [Presentation] Osteoconductivity of Hydroxyapatite by Electrical Polarization Processing (2008)
  • Author(s): Enhanced
  • Organizer: The 9th Japan-Korea Congress of Plasticand Reconstructive Surgery
  • Place of Presentation: Okinawa, Japan
• [Presentation] Ingrowth into Hydroxyapatite with Interconnected Pores by Electrical Polarization (2008)
  • Author(s): Enhanced Bone
  • Organizer: 8th World Biomaterials Congress 2008
  • Place of Presentation: Amsterdam, Netherland
• [Presentation] (2008)
  • Organizer: Electret bioceramics for bone regeneration 2008CMCEE & LCS conference
  • Place of Presentation: Shanghai, China
• [Presentation] 国内バイオセラミックスの電気分極処理及び生体に及ぼす影響 (2008)
  • Organizer: 第7回日本再生医療学会
  • Place of Presentation: 名古屋
• [Presentation] Electret Bioceramics for bone Tissue Regeneration (2008)
  • Organizer: 日本バイオマテリアル学会シンポジウム
  • Place of Presentation: 東京
• [Presentation] Enhanced Bone Ingrowth into Hydroxyapatite with Interconnected Pores by Electrieal Polarization (2008)
  • Author(s): Wang W., et.
  • Organizer: 8th World Biomaterials Congress 2008
  • Place of Presentation: Amsterdam, Netherland
• [Presentation] Electret bioceramics for bone regeneration (2008)
  • Author(s): Wang W., et.
  • Organizer: 008CMCEE&LCS conference
  • Place of Presentation: Shanghai, China
• [Presentation] Electret Bioceramies for bone Tissue Regeneration (2008)
  • Author(s): 王 巍 等
  • Organizer: 日本バイオマテリアル学会シンポジウム2008
  • Place of Presentation: 東京
• [Presentation] 足場材料の配向性が末梢神経および脊髄の再生に及ぼす効果 (2008)
  • Author(s): 伊藤聰一郎、王巍、福島和之、渡部和彦、榎本光裕、久保木芳徳、四宮謙一
  • Organizer: 第7回日本再生医療学会
  • Place of Presentation: 名古屋国際会議場
• [Presentation] バイオセラミックスの電気分極処理及び生体に及ぼす影響 (2008)
  • Author(s): 王巍、伊藤聰一郎、中村美穂、田中優実、山下仁大
  • Organizer: 第7回日本再生医療学会
  • Place of Presentation: 名古屋国際会議場
• [Presentation] Enhanced osteoconductivity of hydroxyapatite by electrical polarization (2008)
  • Author(s): 王巍、伊藤聰一郎、中村美穂、四宮謙一、山下仁大
  • Organizer: 第9回日韓形成外科学会
  • Place of Presentation: 沖縄万国津梁館
• [Presentation] 神経架橋用キトサン・メッシュ・チューブの力学強度と物質透過性が神経再生に及ぼす促進効果 (2007)
  • Author(s): 伊藤聰一郎、王巍、大熊恒雄、四宮謙一
  • Organizer: 第22回日本整形外科学会基礎学術集会
  • Place of Presentation: 浜松アクトシティー
• [Presentation] 電気分極したハイドロキシアパタイト多孔体による骨再生の促進 (2007)
  • Author(s): 王巍、伊藤聰一郎、大橋菜多里、中村美穂、岩崎健、山下仁大
  • Organizer: 第10回日本組織工学会
  • Place of Presentation: 大手町サンケイプラザ