Acetylcholine signal in the monkey striatum for trial-and-error based decision making

• Project/Area Number: 19800033
• Research Category: Grant-in-Aid for Young Scientists (Start-up)
• Allocation Type: Single-year Grants
• Research Field: Neurophysiology and muscle physiology
• Research Institution: Kyoto Prefectural University of Medicine
• Principal Investigator: YAMADA Hiroshi Kyoto Prefectural University of Medicine, 医学部, 博士研究員 (70453115)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥3,125,000 (Direct Cost: ¥2,720,000、Indirect Cost: ¥405,000); Fiscal Year 2008: ¥1,755,000 (Direct Cost: ¥1,350,000、Indirect Cost: ¥405,000); Fiscal Year 2007: ¥1,370,000 (Direct Cost: ¥1,370,000)
• Keywords: 大脳基底核 / 線条体 / 意志決定 / 行動選択 / 報酬 / ドーパミン / アセチルコリンサル / アセチルコリン / サル

Research Abstract

大脳基底核の線条体に含まれるアセチルコリンは試行錯誤で行動するために重要な報酬信号を検出し、思考や意志決定などの高次認知機能に深く関わる可能性が示唆されている。自由意志で行動を企画・実行する課程に線条体のアセチルコリンが寄与するメカニズムを知るために、サル線条体のアセチルコリン受容体の機能脱落実験を行った。その結果、線条体のアセチルコリンが試行錯誤で適切な行動を見つけ出す過程に寄与する結果を得た。線条体のアセチルコリンが、現在の行動の結果を次の行動へと反映させる過程を仲介すると考えられる。

Research Products

• [Journal Article] History-and current instruction-based coding of forthcoming behavioral outcomes in the striatum (2007)
  • Author(s): Yamada H, Matsumoto N, Kimura M.
  • Journal Title: The Journal of Neurophysiology 98 Pages: 3557-3567
  • Peer Reviewed
• [Journal Article] History-and current instruction-based coding of forthcoming behavioral outcomes in the striatum (2007)
  • Author(s): Yamada H, Matsumoto N, Kimura
  • Journal Title: The Journal of Neurophysiology 98 Pages: 3557-3567
  • Peer Reviewed
• [Presentation] Muscimol injection into the putamen selectively impairs reward value-based action selection. Neurosci.Res. Suppl.59 (2008)
  • Author(s): Muranishi M (発表者), Inokawa H, Yamada H, Kimura M.
  • Organizer: 第31回日本神経科学学会
  • Place of Presentation: 東京
  • Year and Date: 2008-07-10
• [Presentation] Muscimol injection into the putamen selectively impairsreward value-based action selection (2008)
  • Author(s): MuranishiM, Inokawa H, Yamada H, Kimura M
  • Organizer: 日本神経科学学会
  • Place of Presentation: 東京国際フォーラム
  • Year and Date: 2008-07-10
• [Presentation] Cholinergic signal in the striatum during multi-step choice task for reward (2007)
  • Author(s): Inokawa H (発表者), Yamada H, Kimura M
  • Organizer: 第30回日本神経科学学会
  • Place of Presentation: 横浜(Neurosci. Res. Suppl. 58 : S229. P3-h06)
  • Year and Date: 2007-09-12
• [Presentation] Cholinergic signal in the striatum during multi-step choice task for reward (2007)
  • Author(s): Inokawa H, Yamada H, Kimura M
  • Organizer: 第30回日本神経科学学会
  • Place of Presentation: 横浜
  • Year and Date: 2007-09-12
• [Presentation] Neuronal coding of reinforcers during multi-step choice task in the striatum. Neurosci. Res. Suppl (2007)
  • Author(s): Yamada H (発表者), Inokawa H, Kimura M.
  • Organizer: 第30回日本神経科学学会
  • Place of Presentation: 横浜(8 : S114. P1-h05)
  • Year and Date: 2007-09-10
• [Presentation] Neuronal coding of reinforcers during multi-step choice task in the striatum. (2007)
  • Author(s): Yamada H, Inokawa H, Kimura M
  • Organizer: 第30回日本神経科学学会
  • Place of Presentation: 横浜
  • Year and Date: 2007-09-10
• [Presentation] Signals of striatal projection neurons, tonically active neurons and dopamine neurons during reward-based decision-making and action selection. J.Physiol. Sci (2007)
  • Author(s): Yamada H(発表者), Inokawa H, Matsumoto N, Enomoto K, Kimura M.
  • Organizer: 第84回日本生理学会
  • Place of Presentation: 大阪(57(Suppl) : S8. 1SC02-3)
  • Year and Date: 2007-03-21