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Structural and functional analysis of type III polyketide synthases from filamentous fungi

Research Project

Project/Area Number 19810018
Research Category

Grant-in-Aid for Young Scientists (Start-up)

Allocation TypeSingle-year Grants
Research Field Living organism molecular science
Research InstitutionNational Institute of Health Sciences (2008)
Iwate Medical University (2007)

Principal Investigator

SESHIME Yasuyo  National Institute of Health Sciences, 生薬部, 流動研究員 (30453319)

Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥3,115,000 (Direct Cost: ¥2,710,000、Indirect Cost: ¥405,000)
Fiscal Year 2008: ¥1,755,000 (Direct Cost: ¥1,350,000、Indirect Cost: ¥405,000)
Fiscal Year 2007: ¥1,360,000 (Direct Cost: ¥1,360,000)
Keywords糸状菌 / 二次代謝産物 / ポリケタイド / 生合成 / Aspergillus oryzae / ポリケタイド合成酵素
Research Abstract

III型ポリケタイド合成酵素(PKS)は、これまで、植物及び一部原核微生物に分布することが既に知られていた。今回、真核微生物について解析を進め、麹菌Aspergillus oryzaeのIII型PKS遺伝子csyA発現株が3,5-dihydroxybenzoic acid(DHBA)を主生成物として与えることを明らかにした。さらに、csyB発現株は、germicidin様新規化合物を主生成物として与えることを明らかにした。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (3 results)

All 2010 2007

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (2 results)

  • [Journal Article] Identification of csypyrone B1 as the novel product of Aspergillus oryzae type III polyketide synthase CsyB2010

    • Author(s)
      Yasuyo Seshime, Praveen Rao Juvvadi, Katsuhiko Kitamoto, Yutaka Ebizuka, Isao Fujii.
    • Journal Title

      Bioorganic & Medicinal Chemistry (in press)

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Presentation] 麹菌 Aspergillus oryzae のIII型ポリケタイド合成酵素2007

    • Author(s)
      勢〆康代, 北本勝ひこ, 海老塚豊, 藤井勲
    • Organizer
      第59回日本生物工学会
    • Place of Presentation
      広島
    • Year and Date
      2007-09-25
    • Related Report
      2008 Final Research Report
  • [Presentation] 麹菌Aspergillus oryzaeのIII型ポリケタイド合成酵素2007

    • Author(s)
      勢 康代
    • Organizer
      第59回日本生物工学会
    • Place of Presentation
      広島
    • Year and Date
      2007-09-25
    • Related Report
      2007 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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