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Chemical and biological study for effective application of traditional medicinal resources

Research Project

Project/Area Number 19850020
Research Category

Grant-in-Aid for Young Scientists (Start-up)

Allocation TypeSingle-year Grants
Research Field Chemistry related to living body
Research InstitutionTakasaki University of Health and Welfare

Principal Investigator

KANEKO Masafumi  Takasaki University of Health and Welfare, 薬学部, 准教授 (50433636)

Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥3,105,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥405,000)
Fiscal Year 2008: ¥1,755,000 (Direct Cost: ¥1,350,000、Indirect Cost: ¥405,000)
Fiscal Year 2007: ¥1,350,000 (Direct Cost: ¥1,350,000)
KeywordsTabebuia avellanedae / Taheebo / 補完代替医療 / がん化学予防 / NFD / カルス / 後発がん促進 / 抗発がん促進 / ポリケチド合成酵素 / 伝承薬
Research Abstract

ブラジル原産の伝承薬T. avellanedae の細胞を培養することにより抗がん活性をもつ5-hydroxy-2-(1-hydroxyethyl)-naphtho[2,3-b]-furan-4,9-dione(NQ801)を効率的に生産する方法の開発を行った。この化合物あるいはT. avellanedae の抽出物を用い、様々な腫瘍細胞に対する毒性試験、がん初期抗原発現抑制試験、マウスを用いた抗腫瘍活性試験を行った。その結果、本植物の医薬素材としての応用の可能性が広がった。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (5 results)

All 2009 2008 2007

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (4 results)

  • [Journal Article] Stereoselective Synthesis and Cytotoxicity of a cancer Chemopreventive Naphthoquinone from Tabebuia avellanedae2007

    • Author(s)
      Mitsuaki Yamashita, Masafumi Kaneko, Akira Iida, Harukuni Tokuda, and Katsumi Nishimura
    • Journal Title

      Bioorg. Med. Chem. Lett. 2007 17

      Pages: 6417-6420

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Presentation] ブラジル原産Tabebuia avellanedae由来成分の抗腫瘍活性2009

    • Author(s)
      金子雅文ほか4名
    • Organizer
      日本薬学会第129年会
    • Place of Presentation
      国立京都国際会館
    • Year and Date
      2009-03-26
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] 南米産伝統薬物Tabebuia avellanedaeエキスの抗腫瘍効果2008

    • Author(s)
      金子雅文ほか3名
    • Organizer
      日本生薬学会第55回年会
    • Place of Presentation
      長崎大学
    • Year and Date
      2008-09-19
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] ブラジル原産 Tabebuia avellanedae 由来成分の構造と生物活性2008

    • Author(s)
      金子雅文ほか3名
    • Organizer
      日本薬学会第128 年会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2008-03-26
    • Related Report
      2008 Final Research Report
  • [Presentation] ブラジル原産Tabebuia avellanedae由来成分の構造と生物活性2008

    • Author(s)
      金子 雅文, ほか3名
    • Organizer
      日本薬学会第128年会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Year and Date
      2008-03-26
    • Related Report
      2007 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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