Functional analysis of the PFR as a new signaling center for specifying each digit identity

• Project/Area Number: 19870001
• Research Category: Grant-in-Aid for Young Scientists (Start-up)
• Allocation Type: Single-year Grants
• Research Field: Developmental biology
• Research Institution: Tohoku University
• Principal Investigator: SUZUKI Takayuki Tohoku University, 加齢医学研究所, 助教 (40451629)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥3,125,000 (Direct Cost: ¥2,720,000、Indirect Cost: ¥405,000); Fiscal Year 2008: ¥1,755,000 (Direct Cost: ¥1,350,000、Indirect Cost: ¥405,000); Fiscal Year 2007: ¥1,370,000 (Direct Cost: ¥1,370,000)
• Keywords: 指の個性 / 骨 / BMP / ニワトリ / 発生生物学 / PFR / 指間部 / 分子生物学

Research Abstract

私たちは5本の指を持っており、それぞれの指は親指から小指にかけて異なった特徴ある形態をしています。今回、この形の違いが生み出されるメカニズムをニワトリの受精卵を使って調べました。その結果、発生中に指先の先端に指を造るために重要な細胞群を見いだし、PFR(指骨形成領域)の細胞群を新たに命名しました。さらにこの細胞群は指原器の後側の指間部からBMP(骨形成成長因子)を受け取っており、それぞれの指原器のPFRが受け取るBMPシグナルの量的な違いによって指の個性が決定されていることが分かりました。

Research Products

• [Journal Article] Unique SMAD1/5/8 activity at the phalanx-forming region determines digit identity (2008)
  • Author(s): Suzuki T., Hasso S. M. and Fallon J. F.
  • Journal Title: Proc Natl Acad Sci USA 18 Pages: 4185-4190
• [Journal Article] Congenic method in the chick limb buds by electroporation (2008)
  • Author(s): Suzuki T. and Ogura T.
  • Journal Title: Dev Growth Differ(Review) 50 Pages: 459-465
  • NAID: 10021097161
• [Journal Article] Unique SMAD1/5/8 activity at the phalanx-forming region determines digit identity. (2008)
  • Author(s): Suzuki, T., Hasso, S. M., and Fallon, J. F.
  • Journal Title: Proc Natl Acad Sci USA. 18 Pages: 4185-4190
  • Peer Reviewed
• [Presentation] Unique SMAD1/5/8 activity at the phalanx-forming region determines digit Unique SMAD1/5/8 activity at the phalanx-forming region determines digit identity (2008)
  • Author(s): Takayuki Suzuki, Sean M. Hasso, John F. Fallon, Toshihiko Ogura
  • Organizer: Chemotaxis to Development OIST meeting
  • Place of Presentation: 沖縄
  • Year and Date: 2008-11-15
• [Presentation] Unique SMAD1/5/8 activity at the phalanx-forming region determines digit identity Chemotaxis to Development (2008)
  • Author(s): Takayuki Suzuki, Sean M. Hasso, John F. Fallon, Toshihiko Ogura
  • Organizer: Chemotaxis to Development
  • Place of Presentation: 沖縄
  • Year and Date: 2008-11-15
• [Presentation] Fallon. Unidirectional sensitivity exists at the PFR to specify digit identity through unique level of SMAD1/5/8 activity (2008)
  • Author(s): Suzuki T., Sean M. Hasso. and John F.
  • Organizer: 日本発生生物学会
  • Place of Presentation: 徳島市
  • Year and Date: 2008-05-26
• [Presentation] Unique SMAD1/5/8 activity at the phalanx-forming region determines digit identity. (2007)
  • Author(s): Suzuki, T., Hasso, S. M., and Fallon, J. F.
  • Organizer: Society of Developmental Biology 66th Annual Meeting
  • Place of Presentation: Cancun, Mexico
  • Year and Date: 2007-06-16
• [Book] Electroporation into the limb : beyond misexpression (2009)
  • Author(s): Takayuki Suzuki and Toshihiko Ogura
  • Publisher: Electroporation and Sonoporation in Developmental Biology, Springer
• [Book] Electroporation and Sonoporation in Developmental Biology (2009)
  • Author(s): Electroporation into the limb : beyond misexpression
  • Total Pages: 13
  • Publisher: Springer
• [Remarks]
  • URL: http://web.me.com/stakayuki77/Ogura_lab/Top.html
• [Remarks]
  • URL: http://www.lifesci.tohoku.ac.jp/teacher/neuro/a_tysuzuki.html
• [Remarks]
  • URL: http://www.lifesci.tohoku.ac.jp/teacher/neuro/a_tysuzuki.html