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Physiological function of polyamines in brain-possible regulating factor of glial function-

Research Project

Project/Area Number 19880025
Research Category

Grant-in-Aid for Young Scientists (Start-up)

Allocation TypeSingle-year Grants
Research Field Basic veterinary science/Basic zootechnical science
Research InstitutionOsaka Prefecture University

Principal Investigator

TAKANO Katsura  Osaka Prefecture University, 生命環境科学研究科, 助教 (50453139)

Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥3,125,000 (Direct Cost: ¥2,720,000、Indirect Cost: ¥405,000)
Fiscal Year 2008: ¥1,755,000 (Direct Cost: ¥1,350,000、Indirect Cost: ¥405,000)
Fiscal Year 2007: ¥1,370,000 (Direct Cost: ¥1,370,000)
Keywordsミクログリア / アストロサイト / 神経変性疾患 / ポリアミン
Research Abstract

脳内には神経細胞以外に補助細胞であるグリア細胞が存在し、その活性変化は神経変性疾患発症メカニズムに関与することが指摘されている。グリア細胞の1つであるアストロサイトにおいて、細胞活性化刺激を行うことにより、神経変性疾患の凝集体形成に関わる酵素であるトランスグルタミナーゼの発現上昇が認められた。したがって、グリア細胞の活性化にトランスグルタミナーゼが関与し、活性化したグリア細胞において発現増加したトランスグルタミナーゼが神経変性疾患の原因となる可能性が示唆された。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (14 results)

All 2009 2008 2007 Other

All Journal Article (5 results) (of which Peer Reviewed: 5 results) Presentation (5 results) Remarks (4 results)

  • [Journal Article] A carbazole derivative protects cells against endoplasmic reticulum(ER)stress and glutathione depletion2008

    • Author(s)
      Hikari Miura, Katsura Takano, Yasuko Kitao, Satoshi Hibino, Tominari Choshi, Rika Murakami, Hiroto Suzuki, Masashi Yamada, Satoshi Ogawa, Osamu Hori
    • Journal Title

      Journal of Pharmacological Sciences 108

      Pages: 164-171

    • NAID

      10024384874

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of Amphotericin B on the expression of neurotoxic and neurotrophic factors in cultured microglia2008

    • Author(s)
      Akiko Motoyoshi, Hidemitsu Nakajima, Katsura Takano, Mitsuaki Moriyama, Yukiko Kannan, Yoichi Nakamura
    • Journal Title

      Neurochemistry International 52

      Pages: 1290-1296

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of Amphotericin B on the expression of neurotoxic and neurotrophic factors in cultured microglia.2008

    • Author(s)
      Akiko Motoyoshi
    • Journal Title

      Neurochemistry International 52

      Pages: 1290-1296

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A carbazole derivative protects cells against endoplasmic reticulum (ER) stress and glutathione depletion.2008

    • Author(s)
      Hikari Miura
    • Journal Title

      Journal of Pharmacological Sciences 108

      Pages: 164-171

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of Amphotericin B on the expression of neurotoxic and neurotro phic factors in cultured microglia2008

    • Author(s)
      Akiko Motoyoshi
    • Journal Title

      Neurochemistry International 52

      Pages: 1290-1296

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] LPS-induced transglutaminase 2 expression and the involvement of NO production in cultured astrocytes2009

    • Author(s)
      高野桂、白岩謙介、森山光章、中村洋一
    • Organizer
      第82回日本薬理学会年会
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2008 Final Research Report
  • [Presentation] LPS-induced transglutaminase 2 expression and the involvement of NO production in cultured astrocyte.2009

    • Author(s)
      高野桂
    • Organizer
      第82回日本薬理学会年会
    • Place of Presentation
      神奈川, 横浜(パシフィコ横浜)
    • Related Report
      2008 Annual Research Report
  • [Presentation] LPS-induced transglutaminase 2 expression and the involvement of NO production in rat brain astrocyte2008

    • Author(s)
      高野桂、白岩謙介、森山光章、中村洋一
    • Organizer
      第51回日本神経化学会大会
    • Place of Presentation
      富山国際会議場
    • Related Report
      2008 Final Research Report
  • [Presentation] LPS-induced transglutaminase 2 expression and the involvement of NO production in rat brain astrocyte.2008

    • Author(s)
      高野桂
    • Organizer
      第51回日本神経化学会大会
    • Place of Presentation
      富山(富山国際会議場)
    • Related Report
      2008 Annual Research Report
  • [Presentation] 血清存在下でのポリアミンによる培養ミクログリアの細胞死誘導2007

    • Author(s)
      高野桂、中村洋一
    • Organizer
      第12回グリア研究会
    • Place of Presentation
      名古屋大学
    • Year and Date
      2007-11-17
    • Related Report
      2008 Final Research Report 2007 Annual Research Report
  • [Remarks]

    • URL

      http://gweb.acs.osakafu-u.ac.jp:7780/kyoinkensaku/

    • Related Report
      2008 Final Research Report
  • [Remarks] (1)Katsura Takano, Kensuke Shiraiwa, Mitsuaki Moriyama, Yoichi Nakamura. LPS-induced transglutaminase 2 expression and the involvement of NO production in cultured astrocytes. Journal of Pharmacological Scinences, 109, Suppl. 1 ; 124P. 2009

    • Related Report
      2008 Final Research Report
  • [Remarks] (2)Katsura Takano, Kensuke Shiraiwa, Mitsuaki Moriyama, Yoichi Nakamura. LPS-induced transglutaminase 2 expression and the involvement of NO production in rat brain astrocyte. 神経化学(Bulletin of the Japanese Society for Neurochemistry), 47(No.2, 3) ; 262. 2008

    • Related Report
      2008 Final Research Report
  • [Remarks] (3)高野桂、中村洋一. 血清存在下でのポリアミンによる培養ミクログリアの細胞死誘導. 第12回グリア研究会プログラム, 12. 2007

    • Related Report
      2008 Final Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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