Regulatory mechanism of BMP-dependent osteoblast differentiation through TNF/JNK signaling pathway
| Project/Area Number |
19890027
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| Research Category |
Grant-in-Aid for Young Scientists (Start-up)
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| Allocation Type | Single-year Grants |
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| Research Field |
Functional basic dentistry
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| Research Institution | Tohoku University |
|---|
Principal Investigator |
KUDO Tada-aki Tohoku University, 大学院・歯学研究科, 助教 (50431606)
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|---|
| Project Period (FY) |
2007 – 2008
|
| Project Status |
Completed (Fiscal Year 2008)
|
| Budget Amount *help |
¥3,085,000 (Direct Cost: ¥2,680,000、Indirect Cost: ¥405,000)
Fiscal Year 2008: ¥1,755,000 (Direct Cost: ¥1,350,000、Indirect Cost: ¥405,000)
Fiscal Year 2007: ¥1,330,000 (Direct Cost: ¥1,330,000)
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|---|
| Keywords | BMP / TNF / MAPK / JNK / Dullard / 骨芽細胞分化 |
|---|
| Research Abstract |
BMP受容体の一つ、BMPRIIは、C末端領域のThr977がリン酸化酵素JNKによりリン酸化され、一方では脱リン酸化酵素Dullardにより分解の促進を受ける。本研究では、Dullardの機能とBMPRII部分欠失変異体との関係等や、Thr977がリン酸化を受けないBMPRII[T977A]変異体安定発現細胞が示す、野生型BMPRII安定発現細胞と異なる表現型についての新たな知見が得られた
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Report
(3 results)
Research Products
(18 results)
