The usefulness of PET-CT for diagnosis and treatment for maxillofacial tumor based on the metabolism -Clinical aplication of heavy-ion radiotherapy-

• Project/Area Number: 19890037
• Research Category: Grant-in-Aid for Young Scientists (Start-up)
• Allocation Type: Single-year Grants
• Research Field: Surgical dentistry
• Research Institution: Gunma University
• Principal Investigator: MIYAKUBO Mitsuyuki Gunma University, 医学部, 医員 (50451729)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥3,023,000 (Direct Cost: ¥2,630,000、Indirect Cost: ¥393,000); Fiscal Year 2008: ¥1,703,000 (Direct Cost: ¥1,310,000、Indirect Cost: ¥393,000); Fiscal Year 2007: ¥1,320,000 (Direct Cost: ¥1,320,000)
• Keywords: 外科系歯学・放射線 / X線 / 粒子線・頭頸部腫瘍・ポジトロンCT / 外科系歯学 / 放射線,X線,粒子線 / 頭頸部腫瘍 / ポジトロンCT

Research Abstract

顎口腔腫瘍症例に対し、治療前後にF-18標識αメチルタイロシン(FMT)および18F-FDGを用いたPET-CT検査を実施し、画像と病理組織診断結果などとの対比を行った。検査結果からは、FMTの集積は増殖能の高い腫瘍への特異性が高いことが確認された。対象症例において、HE・免疫組織化学染色を行った。これらの結果を、2007年度北米核医学会議などにて報告を行い、医学雑誌に投稿・審査中である。今後も種々の実験結果を加え、データの妥当性を検証する。

Research Products

• [Journal Article] Early diagnosis of recurrent hepatocellular carcinoma with 18F-FDG PET after radiofrequency ablation therapy. Ann Nucl Med. (2008)
  • Author(s): Paudyal B, Miyakubo M, et.al. (他7名)
  • Journal Title: Annals of Nuclear Medicine 22(1) Pages: 83-86
  • Peer Reviewed
• [Journal Article] Early diagnosis of recurrent hepatocellular carcinoma with 18F-FDG PET after radiofrequency ablation therapy (2008)
  • Author(s): Paudyal B
  • Journal Title: Ann Nucl Med 22(1) Pages: 83-86
  • Peer Reviewed
• [Journal Article] Clinicopathological presentation of varying 18F-FDG uptake and expression of glucose transporter 1 and hexokinase II in cases of hepatocellular carcinoma and cholangiocellular carcinoma (2007)
  • Author(s): Paudyal B, Miyakubo M, et.al. (他9名)
  • Journal Title: Oncology Reports Vol.18 Pages: 1469-1473
  • NAID: 10021280263
  • Peer Reviewed
• [Journal Article] Clinicopathological presentation of varying 18F-FDG uptake and expression of glucose transporter 1 and hexokinase II in cases of hepat6cellular carcinoma and cholangiocellular carcinoma (2007)
  • Author(s): Paudyal B
  • Journal Title: Oncol Rep 18(6) Pages: 1469-1473
  • Peer Reviewed
• [Presentation] 顎口腔腫瘍におけるFMT-PETの有用性 : FDG-PETとの比較検討 (2009)
  • Author(s): 宮久保満之, ら
  • Organizer: 第27回口腔腫瘍学会総会
  • Place of Presentation: 宇都宮市
• [Presentation] 顎口腔腫瘍におけるFMT-PETの有用性:FDG-PETとの比較検討 (2009)
  • Author(s): 宮久保満之
  • Organizer: 第27回口腔腫瘍学会総会
  • Place of Presentation: 宇都宮市
• [Presentation] 病期診断目的に施行したFDG-PETで重複癌と診断された舌癌の1例 (2008)
  • Author(s): 宮下 剛, 宮久保満之, ら
  • Organizer: 群馬県核医学研究会
  • Place of Presentation: 前橋市
  • Year and Date: 2008-11-08
• [Presentation] L-[F-18]-alpha-methyl tyrosine PET for the diagnosis of pulmonary adenocarcinoma (2008)
  • Author(s): Miyashita G, Miyakubo M et.al.
  • Organizer: The 21st Century COE Program The Fourth International Symposium on Biomedical Research Using Accelerator Technology in Gunma
  • Place of Presentation: Maebashi
• [Presentation] L-[F-18]-alpha-methyl tyrosine PET for the diagnosis of pulmonary adenocarcinoma (2008)
  • Author(s): G.Miyashita , M. Miyakubo et al
  • Organizer: The 21st Century COE Program The Fourth International Symposium on Biomedical Research Using Accelerator Technology in Gunma
  • Place of Presentation: 前橋市
• [Presentation] Diagnosis of maxillofacial tumor with L-3-[^<18>]F- fluoro-α-methyltyrosine(FMT) PET : a comparative study with FDG-PET (2007)
  • Author(s): Miyakubo M et. al.
  • Organizer: Societyof Nuclear Medicine 54 Annual Meeting
  • Place of Presentation: Washington D.C.
• [Presentation] Diagnosis of maxillofacial tumor with L-3-[^<18>F]-fluoro-α-methyltyrosine(FMT)PET:a comparative study with FDG-PET (2007)
  • Author(s): Miyakubo M
  • Organizer: Society of Nuclear Medicine 54rd Annual Meeting
  • Place of Presentation: Washington D.C