Analysis of RGMa functions in immune cells

• Project/Area Number: 19890044
• Research Category: Grant-in-Aid for Young Scientists (Start-up)
• Allocation Type: Single-year Grants
• Research Field: Cerebral neurosurgery
• Research Institution: Chiba University
• Principal Investigator: KUBO Takekazu Chiba University, 大学院・医学研究院, 助教 (80451756)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥3,085,000 (Direct Cost: ¥2,680,000、Indirect Cost: ¥405,000); Fiscal Year 2008: ¥1,755,000 (Direct Cost: ¥1,350,000、Indirect Cost: ¥405,000); Fiscal Year 2007: ¥1,330,000 (Direct Cost: ¥1,330,000)
• Keywords: 脳・神経 / 神経疾患 / 神経科学 / 免疫学 / 中枢神経傷害 / 神経免疫

Research Abstract

中枢神経軸索の再生阻害因子repulsive guidance molecule(RGMa)が免疫細胞にどのような効果を示すかを検討した結果,RGMaはCD4陽性ヘルパーT細胞を含む免疫細胞を活性化することを見出した。またRGMaの作用を抑制することで,過剰な免疫反応により誘導される動物疾患モデルである実験的自己免疫性脳脊髄炎が抑制されることを発見した。本結果は、RGMaが過剰な免疫反応を原因とする多発性硬化症などの中枢神経疾患の治療標的となることを示唆する。

Research Products

• [Journal Article] Regulation of axonal elongation and pathfinding from the entorhinal cortex to the dentate gyrus in the hippocampus by the chemokine stromal cell-derived factor 1alpha (2008)
  • Author(s): Ohshima Y, Kubo T (corresponding author), Koyama R, Ueno M, Nakagawa M, Yamashita T
  • Journal Title: Journal of Neuroscience 28 Pages: 8344-8353
  • Peer Reviewed
• [Journal Article] Neogenin regulates neuronal survival through DAP-kinase (2008)
  • Author(s): Fujita Y., Taniguchi J., Uchikawa M., Endo M., Hata K., Kubo T., Mueller B.K. and Yamashita T.
  • Journal Title: Cell Death and Differentiation 15 Pages: 1593-1608
  • Peer Reviewed
• [Journal Article] Inhibition of branching and spine maturation by repulsive guidance molecule in cultured cortical neurons (2008)
  • Author(s): Yoshida J., Kubo T. and Yamashita T.
  • Journal Title: Biochemical and Biophysical Research Communications 372 Pages: 725-729
  • Peer Reviewed
• [Journal Article] Peptides derived from repulsive guidance molecule act as antagonists (2008)
  • Author(s): Suda M, Hata K, Sawada A, Nakamura Y, Kubo T, Yamaguchi A, Yamashita T
  • Journal Title: Biochemical and Biophysical Research Communications 371 Pages: 501-504
  • Peer Reviewed
• [Journal Article] The therapeutic effects of Rho-ROCK inhibitors on CNS disorders (2008)
  • Author(s): Kubo T (corresponding author), Yamaguchi A, Iwata N, Yamashita T
  • Journal Title: Therapeutics and Clinical Risk Management 4 Pages: 605-615
  • Peer Reviewed
• [Journal Article] Myosin IIA is required for neurite outgrowth inhibition produced by RGMa (2008)
  • Author(s): Kubo T (corresponding author), Endo M, Hata K, Taniguchi J, Kitajo K, Tomura S, Yamaguchi A, Mueller BK, Yamashita T
  • Journal Title: Journal of Neurochemistry 105 Pages: 113-126
  • Peer Reviewed
• [Journal Article] Rap1 is involved in the signal transduction of myelin-associated glycoprotein (2008)
  • Author(s): Taniguchi J, Fujitani M, Endo M, Kubo T, Fujitani M, Miller FD, Kaplan DR and Yamashita T
  • Journal Title: Cell Death and Differentiation 15 Pages: 408-419
  • Peer Reviewed
• [Journal Article] Regulation of axonal elongation and pathfinding from the entorhinal cortex to the dentate gyrus in the hippocampus by the chemokine stromal cell-derived factor lalpha. (2008)
  • Author(s): Yoichi Ohshima
  • Journal Title: Journal of Neuroscience 28 Pages: 8344-8353
  • Peer Reviewed
• [Journal Article] Neogenin regulates neuronal survival. through DAP-kinase. (2008)
  • Author(s): Yuki Fujita
  • Journal Title: Cell Death and Differentiation 15 Pages: 1593-1608
  • Peer Reviewed
• [Journal Article] Inhibition of branching and spine maturation by repulsive guidance molecule in cultured cortical neurons. (2008)
  • Author(s): Junko Yoshida
  • Journal Title: Biochemical and Biophysical Research Communications 372 Pages: 725-729
  • Peer Reviewed
• [Journal Article] Peptides derived from repulsive guidance molecule act as antagonlsts. (2008)
  • Author(s): Masayoshi Suda
  • Journal Title: Biochemical and Biophysical Research Communications 371 Pages: 501-504
  • Peer Reviewed
• [Journal Article] The therapeutic effects of Rho-ROCK inhibitors on CNS disorders. (2008)
  • Author(s): Takekazu Kubo
  • Journal Title: Therapeutics and Clinical Risk Management 4 Pages: 605-615
  • Peer Reviewed
• [Journal Article] Myosin IIA is required for neurite outgrowth inhibition produced by repulsive guidance molecule (2008)
  • Author(s): 久保 武一
  • Journal Title: Journal of Neuroehemistry 105 Pages: 113-126
  • Peer Reviewed
• [Journal Article] Rap1 is involved in the signal transduction of myelin-associated glycoprotein (2008)
  • Author(s): 谷口 順子
  • Journal Title: Cell Death and Differentiation 15 Pages: 408-419
  • Peer Reviewed
• [Journal Article] BMP inhibits neurite growth by a mechanism dependent on LIM-kinase (2007)
  • Author(s): Matsuura I, Endo M, Hata K, Kubo T, Yamaguchi A, Saeki N, Yamashita T
  • Journal Title: Biochemical and Biophysical Research Communications 360 Pages: 868-873
  • Peer Reviewed
• [Journal Article] Repulsion of cerebellar granule neurons by chondroitin sulfate proteoglycans is mediated by MAPK pathway (2007)
  • Author(s): Kaneko M, Kubo T, Hata K, Yamaguchi A, Yamashita T
  • Journal Title: Neuroscience Letters 423 Pages: 62-67
• [Journal Article] Rho-ROCK inhibitors as emerging strategies to promote nerve regeneration (2007)
  • Author(s): Kubo T (corresponding author), Hata K, Yamaguchi A, Yamashita T
  • Journal Title: Current Pharmaceutical Design 13 Pages: 2493-2499
• [Journal Article] Rho-ROCK inhibitors for the treatment of CNS injury (2007)
  • Author(s): Kubo T (corresponding author), Yamashita T
  • Journal Title: Recent Patents on CNS Drug Discovery 2 Pages: 173-179
• [Journal Article] Rho-ROCK inhibitors as emerging strategies to promote nerve regeneration (2007)
  • Author(s): 久保 武一
  • Journal Title: Current Pharmaceutical Design 13 Pages: 2493-2499
• [Journal Article] Rho-ROCK inhibitors for the treatment of CNS injury (2007)
  • Author(s): 久保 武一
  • Journal Title: Recent Patents on CNS Drug Discovery 2 Pages: 173-179
• [Journal Article] BMP inhibits neurite growth by a mechanism dependent on LIM-kinase (2007)
  • Author(s): 松浦 威一郎
  • Journal Title: Biochemical and Biophysical Research Communications 360 Pages: 868-873
  • Peer Reviewed
• [Journal Article] Repulsion of cerebellar granule neurons by chondroitin sulfate proteoglycans is mediated by MAPK pathway (2007)
  • Author(s): 金子 明夏
  • Journal Title: Neuroscience Letters 423 Pages: 62-67
  • Peer Reviewed
• [Presentation] RGMaの軸索伸展阻害効果はミオシンIIAを介する (2007)
  • Author(s): 久保武一
  • Organizer: 第22回神経組織の成長・再生・移植研究会
  • Place of Presentation: 岡山コンベンションセンター
  • Year and Date: 2007-05-26
• [Presentation] RGMaの軸索伸展阻害効果はミオシンIIAを介する (2007)
  • Author(s): 久保 武一
  • Organizer: 第22回神経組織の成長・再生・移植研究会
  • Place of Presentation: 岡山コンベンションセンタ-
  • Year and Date: 2007-05-26
• [Remarks]
  • URL: http://www.m.chiba-u.ac.jp/class/neurobio/index.html
• [Remarks]
  • URL: http://www.m.chiba-u.ac.jp/class/neurobio/index.html
• [Remarks]
  • URL: http://www.m.chiba-u.ac.jp/class/neurobio/index.html