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Structural biology of MD-2 and TLR4 protein toward a therapeutic drug for sepsis

Research Project

Project/Area Number 19890048
Research Category

Grant-in-Aid for Young Scientists (Start-up)

Allocation TypeSingle-year Grants
Research Field Physical pharmacy
Research InstitutionThe University of Tokyo

Principal Investigator

OHTO Umeharu  The University of Tokyo, 大学院・薬学系研究科, 助教 (90451856)

Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥3,125,000 (Direct Cost: ¥2,720,000、Indirect Cost: ¥405,000)
Fiscal Year 2008: ¥1,755,000 (Direct Cost: ¥1,350,000、Indirect Cost: ¥405,000)
Fiscal Year 2007: ¥1,370,000 (Direct Cost: ¥1,370,000)
Keywords結晶構造解析 / 自然免疫 / エンドトキシン / リポ多糖 / 構造生物学
Research Abstract

エンドトキシンであるLPSの細胞外受容体を構成する蛋白質ヒトMD-2単体の三次元構造とアンタゴニストであるlipid IVaの複合体の三次元構造を解析した。MD-2には大きな疎水的ポケットが存在すること, lipid IVaはその疎水的ポケットに結合することから, MD-2 がLPS認識において中心的な役割を担うことを明らかとした。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (7 results)

All 2008 2007 Other

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (2 results) Remarks (1 results)

  • [Journal Article] Crystal twinning of human MD-2 protein recognizing endotoxin cores of lipopolysaccharide2008

    • Author(s)
      Ohto, U. and Satow, Y.
    • Journal Title

      J. Synchrotron. Radiat 15

      Pages: 262-265

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Crystal twinning of human MD-2 protein recognizing endotoxin cores of lipopo lysaccharide2008

    • Author(s)
      Ohto, U. and Satow, Y.
    • Journal Title

      J. Synchrotron. Radiat. 15

      Pages: 262-265

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Crystal structures of human MD-2 and its complex with antiendotoxic lipid Iva2007

    • Author(s)
      Ohto, U., Fukase, K., Miyake, K., and Satow,Y
    • Journal Title

      Science 316

      Pages: 1632-1634

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Crystal structures of human MD-2 and its complex with antiendotoxiclipid IVa2007

    • Author(s)
      Ohto, U., Fukase, K., Miyake, K., and Satow, Y.
    • Journal Title

      Science 316

      Pages: 1632-1634

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] Crystal structures of human MD-2 recognizing bacterial endotoxin2007

    • Author(s)
      Ohto, U. and Satow, Y
    • Organizer
      Biochemistry and molecular Biology 2007
    • Place of Presentation
      横浜
    • Year and Date
      2007-12-12
    • Related Report
      2008 Final Research Report
  • [Presentation] Crystal twinning of human MD-2 protein recognizing endotoxin cores oflipopolysaccharide2007

    • Author(s)
      Ohto, U. and Satow, Y
    • Organizer
      International symposium on diffraction structural biology 2007
    • Place of Presentation
      東京
    • Year and Date
      2007-09-12
    • Related Report
      2008 Final Research Report
  • [Remarks]

    • URL

      http://www.f.u-tokyo.ac.jp/~shomu/old_news.html

    • Related Report
      2007 Annual Research Report

URL: 

Published: 2007-04-01   Modified: 2016-04-21  

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