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Reserch about the pattern when the mannmarian vestibular sensory cells regenerate

Research Project

Project/Area Number 19890056
Research Category

Grant-in-Aid for Young Scientists (Start-up)

Allocation TypeSingle-year Grants
Research Field Otorhinolaryngology
Research InstitutionThe University of Tokyo

Principal Investigator

SUZUKAWA Keigo  The University of Tokyo, 医学部・附属病院, 助教 (50447398)

Co-Investigator(Renkei-kenkyūsha) YAMASOBA Tatsuya  東京大学, 医学部・附属病院, 教授 (60251302)
SUZUKI Miyuya  東京大学, 医学部・附属病院, 准教授 (50302724)
KASHIO Akinori  東京大学, 医学部・附属病院, 助教 (20451809)
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥3,085,000 (Direct Cost: ¥2,680,000、Indirect Cost: ¥405,000)
Fiscal Year 2008: ¥1,755,000 (Direct Cost: ¥1,350,000、Indirect Cost: ¥405,000)
Fiscal Year 2007: ¥1,330,000 (Direct Cost: ¥1,330,000)
Keywords前庭 / 有毛細胞 / 支持細胞 / 再生 / Cytokeratin / Vimentin
Research Abstract

哺乳類前庭感覚器において、傷害後一定期間が経過した後に有毛細胞の数が増加することが知られているが、その再生の様式については現在のところ一定した見解がない。この機序を解明すべく研究をおこなった。モルモットを用いた実験の結果、支持細胞の非対称的な有糸分裂(mitosis)による有毛細胞形成の可能性は低く、支持細胞の有毛細胞への分化転換もしくは傷害有毛細胞の自己修復の可能性が高いと考えられた。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (13 results)

All 2008 2007

All Journal Article (7 results) (of which Peer Reviewed: 7 results) Presentation (6 results)

  • [Journal Article] Distribution and severity of spontaneous lesions in the neuroepithelium and Bowman's glands in mouse olfactory mucosa : age-related progression2008

    • Author(s)
      Kondo K, Watanabe K, Sakamoto T,Suzukawa K, Nibu K, Kaga K, Yamasoba T.
    • Journal Title

      Cell Tissue Res 335

      Pages: 489-503

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Distribution and severity of spontaneous lesions in the neuroepithelium and Bowman's glands in mouse olfactory mucosa: age-related progression.2008

    • Author(s)
      Kondo K, Watanabe K, Sakamoto T, Suzukawa K, Nibu K, Kaga K, Yamasoba T.
    • Journal Title

      Cell Tissue Res 335

      Pages: 489-503

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 動眼神経麻蝉を呈した副鼻腔炎の2症例2008

    • Author(s)
      籠谷領二, 中屋宗雄, 鈴川佳吾, 金谷佳織, 渡辺健太, 山田智佳子, 石尾健一郎
    • Journal Title

      耳鼻咽喉科・順順部外科 80

      Pages: 457-462

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Surgical treatment of medial meatal fibrosis. Report of four cases2007

    • Author(s)
      Suzukawa K, Karino S, Yamasoba T.
    • Journal Title

      Auris Nasus Larynx 85

      Pages: 1403-12

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] A protein derived from the fusion of TAT peptide and FNK,aBcl-x(L) derivative. prevents cochlear hair cell death from aminoglycoside ototoxicity in vivo2007

    • Author(s)
      Kashio A, Sakamoto T, Suzukawa K, Asoh S, Ohta S, Yamasoba T.
    • Journal Title

      J Neurosci Res 85

      Pages: 1403-12

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Surgical treatment of medial meatal fibrosis. Report of four cases.2007

    • Author(s)
      Suzukawa K, Karino S, Yamasoba T.
    • Journal Title

      Auris Nasus Larynx 34

      Pages: 365-8

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A protein derived from the fusion of TAT peptide and FNK, a Bcl-x (L) derivative, prevents cochlear hair cell death from aminoglycoside ototoxicity in vivo.2007

    • Author(s)
      Kashio A, Sakamoto T, Suzukawa K, Asoh S, Ohta S, Yamasoba T.
    • Journal Title

      J Neurosci Res 85

      Pages: 1403-12

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] 嗅上皮傷害モデルマウスにおける嗅上皮再生に及ぼす加齢の影響, 非傷害動物の細胞動態との比較2008

    • Author(s)
      鈴川佳吾, 近藤健二, 坂本幸士, 渡辺健太, 山岨達也
    • Organizer
      日本鼻科学会学術講演会
    • Place of Presentation
      名古屋市
    • Year and Date
      2008-09-27
    • Related Report
      2008 Final Research Report
  • [Presentation] 嗅上皮傷害モデルマウスにおける嗅上皮再生に及ぼす加齢の影響非傷害動物の細胞動態との比較2008

    • Author(s)
      鈴川佳吾, 近藤健二, 坂本幸士, 渡辺健太, 山岨達也
    • Organizer
      日木鼻科学会学術講演会
    • Place of Presentation
      名古屋市
    • Year and Date
      2008-09-27
    • Related Report
      2008 Annual Research Report
  • [Presentation] 嗅上皮傷害物質メチマゾール投与マウスにおいて加齢変化が嗅上皮の再生過程に及ぼす影響の検討2007

    • Author(s)
      鈴川佳吾, 近藤健二, 坂本幸士, 渡辺健太, 山岨達也
    • Organizer
      第46回日本鼻科学会総会
    • Place of Presentation
      宇都宮市
    • Year and Date
      2007-09-28
    • Related Report
      2008 Final Research Report
  • [Presentation] 嗅上皮傷害物質メチマゾール投与マウスにおいて加齢変化が嗅上皮の再生過程に及ぼす影響の検討2007

    • Author(s)
      鈴川佳吾, 近藤健二, 坂本幸士, 渡辺健太, 山岨達也
    • Organizer
      第46回日本鼻科学会総会
    • Place of Presentation
      栃木県宇都宮市
    • Year and Date
      2007-09-28
    • Related Report
      2007 Annual Research Report
  • [Presentation] 当科における小児人工内耳61症例の検討2007

    • Author(s)
      鈴川佳吾, 伊藤健, 山岨達也, 加我君孝
    • Organizer
      第108回日本耳鼻咽喉科学会総会
    • Place of Presentation
      金沢市
    • Year and Date
      2007-05-17
    • Related Report
      2008 Final Research Report
  • [Presentation] 当科における小児人工内耳61症例の検討2007

    • Author(s)
      鈴川佳吾, 伊藤健, 山岨達也, 加我君孝
    • Organizer
      第108回日本耳鼻咽喉科学会総会
    • Place of Presentation
      石川県金沢市
    • Year and Date
      2007-05-17
    • Related Report
      2007 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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