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The function of Xbp-1 under the IL-3 signaling in hematopoiesis and leukemogenesis

Research Project

Project/Area Number 19890061
Research Category

Grant-in-Aid for Young Scientists (Start-up)

Allocation TypeSingle-year Grants
Research Field Pathological medical chemistry
Research InstitutionTokyo Medical and Dental University

Principal Investigator

KURATA Morito  Tokyo Medical and Dental University, 大学院・医歯学総合研究科, 助教 (40451926)

Co-Investigator(Renkei-kenkyūsha) NAKAMURA Takuro  財団法人癌研究会, 癌研究所発がん研究部, 部長 (00180373)
KITAGAWA Masanobu  東京医科歯科大学, 大学院・医歯学総合研究科, 教授 (10177834)
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥3,075,000 (Direct Cost: ¥2,670,000、Indirect Cost: ¥405,000)
Fiscal Year 2008: ¥1,755,000 (Direct Cost: ¥1,350,000、Indirect Cost: ¥405,000)
Fiscal Year 2007: ¥1,320,000 (Direct Cost: ¥1,320,000)
Keywords白血病 / IL-3 / ERストレス / xbp1 / 細胞周期 / insertional mutagenesis / Xbp-1 / ER stress / 細胞分化
Research Abstract

IL-3に関与する遺伝子としてERストレスタンパクであるXbp1(X-box binding protein 1)を同定した。Xbp1はIL-3に発現・活性化がコントロールされており、ノックダウンすると細胞増殖能の低下、apoptosisの誘導が確認された。また、活性型のXbp1を誘導すると抗apoptosis作用が見られ、同時に、細胞周期の停止と骨髄系への分化が確認された。よって、Xbp1はIL-3にコントロールされ、サイトカインシグナルと密接な関係を持ち、細胞の分化・増殖に大きく関わっている。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (9 results)

All 2009 2008 2007

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (6 results)

  • [Journal Article] Induction of integrin betal expression in bone marrow cells after chemotherapy correlates with the overexpression of lung resistance protein and poor outcome in patients with multiple myeloma.2008

    • Author(s)
      Kurata M, Nakagawa Y, Yamamoto K, Suzuki K, Kitagawa M.
    • Journal Title

      American journal hematology 83(9)

      Pages: 755-757

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A novel role for acinus and MCM2 as host-specific signaling enhancers of DNA-damage-induced apoptosis in association with viral protein gp70.2008

    • Author(s)
      Hasegawa M, Kurata M, Yamamoto K, Yoshida K, Aizawa S, Kitagawa M.
    • Journal Title

      Leukemia research Epub ahead of print

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Rapid induction of IAP family proteins and Smac/DIABLO expression after proapoptotic stimulation with doxorubicin in RPMI 8226 multiple myeloma cells.2007

    • Author(s)
      Abe S, Hasegawa M, Yamamoto K, Kurata M, Nakagawa Y, Suzuki K, Takizawa T, Kitagawa M.
    • Journal Title

      Experimental and Molecular Pathology Vol.83,Is sue 3,

      Pages: 405-412

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] 白血病発症におけるERストレスXbp-1の機能2009

    • Author(s)
      倉田盛人、北川昌伸、中村卓郎
    • Organizer
      第98回日本病理学会総会
    • Place of Presentation
      京都
    • Year and Date
      2009-05-01
    • Related Report
      2008 Final Research Report
  • [Presentation] Identification of the Xbp-1, ER-stress protein, as a key molecule of the IL-3 signaling in the hematopoietic cell2008

    • Author(s)
      Morito Kurata, Masanobu Kitagawa, Takuro Nakamura
    • Organizer
      67^<th> Annual Meeting of Japanese Cancer Association
    • Place of Presentation
      名古屋
    • Year and Date
      2008-10-28
    • Related Report
      2008 Final Research Report
  • [Presentation] Identification of the Xbp-1 as a key molecule of the cytokine signaling in the growth of the hematopoietic cell2008

    • Author(s)
      Morito Kurata, Masanobu Kitagawa, Takuro Nakamura
    • Organizer
      67^<th> Annual Meeting of Japanese Cancer Association.
    • Place of Presentation
      名古屋
    • Year and Date
      2008-10-28
    • Related Report
      2008 Annual Research Report
  • [Presentation] 血液細胞におけるIL-3シグナルとERストレス蛋白Xbp-1の役割2008

    • Author(s)
      倉田盛人、北川昌伸、中村卓郎
    • Organizer
      第97回日本病理学会総会
    • Place of Presentation
      金沢
    • Year and Date
      2008-05-15
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] Identification of the Xbp-1 as a key molecule of the cytokine signaling in the growth of the hematopoietic cell2007

    • Author(s)
      Morito Kurata, Masanobu Kitagawa, Takuro Nakamura
    • Organizer
      66^<th> Annual Meeting of Japanese Cancer Association
    • Place of Presentation
      横浜
    • Year and Date
      2007-10-05
    • Related Report
      2008 Final Research Report
  • [Presentation] Identification of the Xbp-1 as a key molecule of the cytokine signaling in the growth of the hematopoietic cell2007

    • Author(s)
      Morito Kurata, Masanobu Kitagawa, Takuro Nakamura.
    • Organizer
      66th Annual Meeting of Japanese Cancer Association.
    • Place of Presentation
      Yokohama
    • Year and Date
      2007-10-05
    • Related Report
      2007 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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