Identification of periodontal stem cells and their stem cell niche

• Project/Area Number: 19890077
• Research Category: Grant-in-Aid for Young Scientists (Start-up)
• Allocation Type: Single-year Grants
• Research Field: Orthodontic/Pediatric dentistry
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: ONO Noriaki Tokyo Medical and Dental University, 歯学部・附属病院, 医員 (20451908)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥3,085,000 (Direct Cost: ¥2,680,000、Indirect Cost: ¥405,000); Fiscal Year 2008: ¥1,755,000 (Direct Cost: ¥1,350,000、Indirect Cost: ¥405,000); Fiscal Year 2007: ¥1,330,000 (Direct Cost: ¥1,330,000)
• Keywords: 歯周組織 / 幹細胞 / 幹細胞ニッチ / 外胚葉性間葉 / 血管内皮 / 血管周皮 / 血管形成 / 微小血管 / 長期ラベル保持能 / 歯根膜 / 再生 / 歯の移動 / 歯根形成

Research Abstract

歯を支える周りの組織(歯周組織)は外部からの刺激に対して適応する能力に優れ、高い再生能力を有する。本研究においては、硬組織の新鮮切片を用いた蛍光抗体による多重染色を行い、歯周組織において「上皮系細胞」と「血管内皮細胞」が特殊な鞘状の構造を形成し、その周囲に未熟な細胞の集団が存在することを同定した。この未熟な細胞の集団は組織の恒常性の維持と再生能に関与していることが示唆される。

Research Products

• [Journal Article] Kronenberg and Masaki Noda Osteopontin Negatively Regulates Parathyroid Hormone Receptor Signaling in Osteoblasts (2008)
  • Author(s): Noriaki Ono, Kazuhisa Nakashima, Susan R. Rittling, Ernestina Schipani, Tadayoshi Hayata, Yoichi Ezura, Kunimichi Soma, David T. Denhardt, Henry M.
  • Journal Title: The Journal of Biological Chemistry vol. 283 (28) Pages: 19400-9
  • Peer Reviewed
• [Journal Article] Osteopont in Negatively Regulates Parathyroid HormoneReceptor Signal ing in Osteoblasts (2008)
  • Author(s): Ono N, Nakashima K, Rittling SR, Schipani E, Hayata T, Soma K, DenhardtDT, Kronenberg HM, EzuraY, Noda M
  • Journal Title: The Journal of Biological Chemistry 283 Pages: 1940019409-1940019409
  • Peer Reviewed
• [Journal Article] Kronenberg and Masaki Noda Constitutively Active Parathyroid Hormone Receptor Signaling in Cells in Osteoblastic Lineage Suppresses Mechanical Unloading-induced Bone Resorption (2007)
  • Author(s): Noriaki Ono, Kazuhisa Nakashima, Ernestina Schipani, Tadayoshi Hayata, Yoichi Ezura, Kunimichi Soma, Henry M.
  • Journal Title: The Journal of Biological Chemistry vol. 282 (35) Pages: 25509-16
  • Peer Reviewed
• [Journal Article] Constitutively Active Parathyroid Hormone Receptor Signaling in Cells in Osteoblastic Lineage Suppresses Mechanical Unloading-induced Bone Resorption (2007)
  • Author(s): Noriaki Ono, Kazuhisa Nakashima, Ernestina Schipani, Tadayoshi Hayata, Yoichi Ezura, Kunimichi Soma, Henry M. Kronenberg and Masaki Noda
  • Journal Title: The Journal of Biological Chemistry 282 Pages: 25509-16
  • Peer Reviewed
• [Presentation] Modulation of parathyroid hormone receptor signaling by microenvironment : Its role in bone metabolism and its implication for orthodontics. (2009)
  • Author(s): Ono N
  • Organizer: The 35th Annual Internat ional Confer ence on Craniofacial Research
  • Place of Presentation: ミシガン大学(米国・ミシガン州アナーバー)
  • Year and Date: 2009-02-27
• [Presentation] Modulation of parathyroid hormone receptor signaling by microenvironment : Its role in bone metabolism and its implication for orthodontics (2009)
  • Author(s): Ono N
  • Organizer: The 35th Annual International Conference on Craniofacial Research, University of Michigan
• [Presentation] Osteoblast-specific constitutive activation of PTH/PTHrP receptor enhances marrow-ablation-induced osteoprogenitor activities (2008)
  • Author(s): Ono N, Nakashima K, Schipani E, Hayata T, Ezura Y, Soma K, Kronenberg HM, Noda M
  • Organizer: International Association for Dental Research, 86th General Session & Exhibition
  • Year and Date: 2008-07-20
• [Presentation] Osteoblast-specific constitutive activation of PTH/PTHrP receptorenhances marrow-ablation-induced osteoprogenitor activities (2008)
  • Author(s): Ono N, Nakashima K, SchipaniE, Hayata T, Ezura Y, Soma K, Kronenberg HM, Noda M
  • Organizer: International Association for Dental Research, 86th General Session & Exhib it ion
  • Place of Presentation: トロント(カナダ)
  • Year and Date: 2008-07-05
• [Presentation] 機械的負荷の除去による骨吸収は骨芽細胞特異的な副甲状腺ホルモン受容体シグナルの活性化により抑制されるConstitutively active parathyroid hormone receptor signaling in osteoblasts suppresses mechanical unloading-induced boneresorption (2007)
  • Author(s): 小野 法明, 相馬 邦道, 中島 和久, 野田 政樹
  • Organizer: 日本矯正歯科学会
  • Place of Presentation: 大阪国際会議場