Roles of chemokines in renal regeneration

• Project/Area Number: 19890082
• Research Category: Grant-in-Aid for Young Scientists (Start-up)
• Allocation Type: Single-year Grants
• Research Field: Kidney internal medicine
• Research Institution: Kanazawa University
• Principal Investigator: FURUICHI Kengo Kanazawa University, 附属病院, 准教授 (50432125)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥3,085,000 (Direct Cost: ¥2,680,000、Indirect Cost: ¥405,000); Fiscal Year 2008: ¥1,755,000 (Direct Cost: ¥1,350,000、Indirect Cost: ¥405,000); Fiscal Year 2007: ¥1,330,000 (Direct Cost: ¥1,330,000)
• Keywords: 腎再生 / ケモカイン / IP-10 / 急性腎不全 / 虚血再還流

Research Abstract

ケモカインの果たす腎再生への役割を明らかにする目的で, 腎虚血再還流モデルに, 抗IP-10中和抗体投与した検討を行ったところ, 尿細管上皮細胞増殖は抗IP-10 中和抗体投により促進されたことから, IP-10 が尿細管細胞の増殖に対して抑制的に働いている事が示唆された. また培養尿細管上皮細胞による検討でも抗IP-10 中和抗体は細胞増殖に促進的に作用した. 以上よりIP-10 が腎再生に関与している事が示唆された.
一方, 腎原基腹膜移植の研究も順調に進み, 腎原基の取り出しのタイミングと, 腹膜および腸間膜への投与方法が確立した. 腹腔内で成長した腎原基は水腎症を呈する事から, 尿管の処理が本治療法の重要なポイントである事が判明した.

Research Products

• [Journal Article] Roles of chemokines in renal ischemia/reperfusion injury (2009)
  • Author(s): Furuichi K, Wada T, Kaneko S, Murphy PM.(1番目)
  • Journal Title: Front Biosci 13 Pages: 4021-4028
  • Peer Reviewed
• [Journal Article] Chemokine/chemokine receptor-mediated inflammation regulates pathologic changes from acute kidney injury to chronic kidney disease (2009)
  • Author(s): Furuichi K, Kaneko S, Wada T. (1番目)
  • Journal Title: Clin Exp Nephrol 13 Pages: 9-14
  • NAID: 10025585552
  • Peer Reviewed
• [Journal Article] Chemokine/chemokine receptor-mediated inflammation regulates pathologic changes from acute kidney injury to chronic kidney disease. (2009)
  • Author(s): 古市賢吾
  • Journal Title: Clin Exp Nephrol 13 Pages: 9-14
  • NAID: 10025585552
  • Peer Reviewed
• [Journal Article] Chemokine receptor CCR1 regulates inflammatory cell infiltration after renal ischemia-reperfusion injury (2008)
  • Author(s): Furuichi K, Gao JL, Horuk R, Wada T,Kaneko S, Murphy PM. (1番目)
  • Journal Title: J Immunol 181 Pages: 8670-8676
  • Peer Reviewed
• [Journal Article] IFN-inducible protein 10 (CXCL10) regulates tubular cell proliferation in renal ischemia-reperfusion injury. (2008)
  • Author(s): Furuichi K, Wada T, Kitajikma S, Toyama T, Okumura T, Hara A, Kawachi H, Shimizu F, Sugaya T, Mukaida N, Narumi S, Matsushima K, Kaneko S. (1番目)
  • Journal Title: Nephron Exp Nephrol 109
  • Peer Reviewed
• [Journal Article] Chemokine receptor CCR1 regulates infiammatory cell infiltration after renal ischemia-reperfusion injury. (2008)
  • Author(s): 古市賢吾
  • Journal Title: J Immunol 181 Pages: 8670-8676
  • Peer Reviewed
• [Journal Article] FN-inducible protein 10 (CXCL10)regulates tubular cell prolniferation in real is chemia-reperfusion injury. (2008)
  • Author(s): 古市賢吾
  • Journal Title: Nephron Exp Nephrol 109
  • Peer Reviewed
• [Journal Article] Roies of chemokines in renal ischemia/re perfusion injury (2008)
  • Author(s): 古市賢吾
  • Journal Title: Front Biosci 13 Pages: 4021-4028
  • Peer Reviewed
• [Presentation] 急性腎不全におけるケモカイン・ケモカイン受容体発現の網羅的測定 (2008)
  • Author(s): 古市賢吾
  • Organizer: 日本臨床検査医学会
  • Place of Presentation: 名古屋
  • Year and Date: 2008-11-28
• [Presentation] Chemokine receptor CCR2-positive macrophage is a key inflammatary cell in acute kidney injury (2008)
  • Author(s): 古市賢吾
  • Organizer: 米国腎臓学会
  • Place of Presentation: 米国,フィラデルフィア
  • Year and Date: 2008-11-06
• [Presentation] Chemokine receptor CCR2-positive macrophage is a key infiammatary cell in acute kidney injury (2008)
  • Author(s): 古市賢吾
  • Organizer: 米国腎臓学会
  • Place of Presentation: 米国, フィラデルフィア
  • Year and Date: 2008-11-06
• [Presentation] 腎虚血 : AKI とCKD をつなぐ炎症機序とその制御 (2008)
  • Author(s): 古市賢吾
  • Organizer: 日本腎臓学会
  • Place of Presentation: 福岡
  • Year and Date: 2008-05-26
• [Presentation] 腎虚血 : AKIとCKDをつなぐ炎症機序とその制御 (2008)
  • Author(s): 古市賢吾
  • Organizer: 日本腎臓学会
  • Place of Presentation: 福岡
  • Year and Date: 2008-05-26
• [Presentation] 腎虚血再還流障害におけるCCR1 の意義 (2007)
  • Author(s): 古市賢吾
  • Organizer: 日本臨床免疫学会
  • Place of Presentation: 大阪
  • Year and Date: 2007-10-19
• [Presentation] 腎虚血再還流障害におけるCCR1の意義 (2007)
  • Author(s): 古市 賢吾
  • Organizer: 日本臨床免疫学会
  • Place of Presentation: 大阪,ホテル阪急エキスポパーク
  • Year and Date: 2007-10-19
• [Presentation] 腎虚血再還流障害におけるCCR1の意義 (2007)
  • Author(s): 古市賢吾
  • Organizer: 日本腎臓学会
  • Place of Presentation: 浜松
  • Year and Date: 2007-05-25