Functional analysis of novel secreted protein, FDC-SP for preventive therapy against periodontitis

• Project/Area Number: 19890097
• Research Category: Grant-in-Aid for Young Scientists (Start-up)
• Allocation Type: Single-year Grants
• Research Field: Periodontal dentistry
• Research Institution: Nagoya University
• Principal Investigator: NAKAMURA Sayaka Nagoya University, 医学部・附属病院, 医員 (40437033)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥3,062,000 (Direct Cost: ¥2,660,000、Indirect Cost: ¥402,000); Fiscal Year 2008: ¥1,742,000 (Direct Cost: ¥1,340,000、Indirect Cost: ¥402,000); Fiscal Year 2007: ¥1,320,000 (Direct Cost: ¥1,320,000)
• Keywords: 歯周病学 / 抗菌タンパク / 歯周組織 / 接合上皮 / 生体防御 / FDC-SP / 自然免疫 / 予防医療

Research Abstract

歯周組織特異的遺伝子の探索において発見された新規遺伝子FDC-SPは歯周組織および耳下腺に特徴的に発現を示す遺伝子で、構造的には唾液成分のスタテリンと類似していることが明らかになっていた。本研究において、FDC-SPは歯肉の接合上皮に局所的に発現していることが明らかになり、抗菌ペプチドとして歯周病原細菌等の外的刺激から歯周組織を保護して口腔内において生体防御機能を担っている可能性が示唆された。今後、FDC-SPの新規歯周病予防法への応用が期待される。

Research Products

• [Journal Article] Adsorption of FDC-SP onto mineral deposits- application of a new stable gene expression system (2008)
  • Author(s): Shinomura, T. Nakamura, S, Ito, K. Shirasawa, SI. Hook, M. and Kimura, JH
  • Journal Title: J Biol Chem 283(48) Pages: 33658-64
  • Peer Reviewed
• [Journal Article] Culture medium study of human mesenchyal stem cells for practical use of tissue engineering and regenerative medicine (2008)
  • Author(s): Nakamura, S, Yamada, Y. Baba, S, Kato, H. Kogami, H. Takao, M. Matsumoto, N. and Ueda, M
  • Journal Title: Biomed Mater Eng 18(3) Pages: 129-136
  • Peer Reviewed
• [Journal Article] Injectable tissue-engineered bone using autogenous bone marrow-derived stromal cells for maxillary sinus augmentation (2008)
  • Author(s): Yamada, Y. Nakamura, S, Ito, K. Kohgo, T. Hibi, H. and Ueda, M
  • Journal Title: Clinical application report from a 2-6-year follow-up, Tissue Eng Part A 14(10) Pages: 1699-1707
  • Peer Reviewed
• [Journal Article] Culture medium study of human mesenchyal stem cells for practical use of tissue engineering and regenerative medicine (2008)
  • Author(s): Nakamura, S
  • Journal Title: Biomed Mater Eng 18(3) Pages: 129-136
  • Peer Reviewed
• [Journal Article] Adsorption of FDC-SP onto mineral deposits-application of a new stable gene expression system (2008)
  • Author(s): Shinomura, T
  • Journal Title: J Biol Chem 283(48) Pages: 33658-64
  • Peer Reviewed
• [Journal Article] Injectable tissue-engineered bone using autogenous bone marrow-derived stromal cells for maxillary sinus augmentation : Clinical application report from a 2-6-year follow-up (2008)
  • Author(s): Yamada, Y
  • Journal Title: Tissue Eng Part A 14(10) Pages: 1699-1707
  • Peer Reviewed
• [Presentation] ヒト乳歯歯髄由来幹細胞の特性の検討 (2008)
  • Author(s): 中村さやか
  • Organizer: 第129回日本歯科保存学会学術大会
  • Place of Presentation: 富山
• [Presentation] The novel sinus floor augmentation using injectable tissue-engineered bone (2008)
  • Author(s): Nakamura S
  • Organizer: 17th Annual Scientific Meeting of European Association for Osseointegration
  • Place of Presentation: Warsaw, Poland
• [Presentation] 新規遺伝子発現システムを用いた歯根膜成分の機能解析 (2008)
  • Author(s): 篠村多摩之
  • Organizer: 第40回日本結合組織学会学術大会
  • Place of Presentation: 東京
• [Presentation] The novel sinus floor augmentation using injectable tissue-engineered bone. (2008)
  • Author(s): Nakamura, S
  • Organizer: 17th Annual Scientific Meeting of European Association for Osseointegration
  • Place of Presentation: Warsaw, Poland
• [Book] 綜合臨床 (2009)
  • Author(s): 中村さやか
  • Publisher: 永井書店