• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Single nucleotide polymorphism in folate related genes in patients with osteosarcoma

Research Project

Project/Area Number 19890131
Research Category

Grant-in-Aid for Young Scientists (Start-up)

Allocation TypeSingle-year Grants
Research Field Orthopaedic surgery
Research InstitutionOkayama University

Principal Investigator

MORIMOTO Yuki  Okayama University, 医学部・歯学部附属病院, 助教 (00452574)

Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥1,800,000 (Direct Cost: ¥1,650,000、Indirect Cost: ¥150,000)
Fiscal Year 2008: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2007: ¥1,150,000 (Direct Cost: ¥1,150,000)
Keywords骨・軟部腫瘍学 / 薬物代謝酵素・トランスポーター / 薬剤感受性 / 骨軟部腫瘍 / 一塩基多型
Research Abstract

骨肉腫患者と健常人における葉酸代謝関連遺伝子であるRFC1とMTHFRの一塩基多型を検討し、日本人の骨肉腫患者ではRFC-1のallele80にAAを持つ群が有意に多いことを発見した。この一塩基多型が骨肉腫の発生に影響を及ぼす可能性が示唆された。また、メソトレキセートによる治療を受けた骨肉腫患者においてRFC1の一塩基多型とメソトレート投与後の肝機能障害、MTHFR allele677の一塩基多型と生命予後とに相関を認め、予後や副作用の予測に有用であると考えられた。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (5 results)

All 2009 2008

All Presentation (5 results)

  • [Presentation] Single Nucleotide Polymorphism of Folic Acid Metabolism Related Genes in Patients with Osteosarcoma2009

    • Author(s)
      Yuki Morimoto, Aki Yoshida, Mamoru Ouchida, Toshiyuki Kunisada, Kenji Shimizu and Toshifumi Ozaki
    • Organizer
      55th Annual Meeting of the Orthopaedic Research Society
    • Place of Presentation
      Las Vegas(USA)
    • Related Report
      2008 Final Research Report
  • [Presentation] Single nucleotide polymorphism in reuced folate carrier-1 gene andmethyleneterahydrofolate reductase gene in patients with osteosarcoma2009

    • Author(s)
      Yuki Morimoto, Aki Yoshida, Mamoru Ouchida, Toshiyuki Kunisada, Kenji Shimizu, Toshifumi Ozaki
    • Organizer
      55th Annual Meeting of the Orthopaedic Research Society
    • Place of Presentation
      Las Vegas (USA)
    • Related Report
      2008 Annual Research Report
  • [Presentation] 骨肉腫患者における葉酸代謝関連遺伝子の一塩基多型の検討2008

    • Author(s)
      森本裕樹, 吉田晶, 大内田守, 国定俊之, 尾崎敏文
    • Organizer
      日本整形外科学会基礎学術集会
    • Place of Presentation
      京都市
    • Year and Date
      2008-10-24
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] 骨肉腫患者における葉酸代謝関連遺伝子の一塩基多型の検討2008

    • Author(s)
      森本裕樹, 吉田晶, 大内田守, 国定俊之, 清水憲二, 尾崎敏文
    • Organizer
      第67回日本癌学会総会
    • Place of Presentation
      名古屋市
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] Single nucleotide polymorphism in reuced folate carrier-1 gene and methyleneterahydrofolate reductase gene in patients with osteosarcoma2008

    • Author(s)
      Yuki Morimoto, Aki Yoshida, Mamoru Ouchida, Kunihiko Numoto, Shinsuke Sugihara, Toshiyuki Kunisada, Kenji Shimizu and Toshifumi Ozaki
    • Organizer
      20Th Meeting of The European Association for Cancer Research
    • Place of Presentation
      Lyon (France)
    • Related Report
      2008 Annual Research Report 2008 Final Research Report

URL: 

Published: 2007-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi