Elucidation of the mechanism for periodontal pocket formation by MMP-2 and Laminin-5 interactions

• Project/Area Number: 19890163
• Research Category: Grant-in-Aid for Young Scientists (Start-up)
• Allocation Type: Single-year Grants
• Research Field: Periodontal dentistry
• Research Institution: Nagasaki University
• Principal Investigator: YOSHINAGA Yasunori Nagasaki University, 医学部・歯学部附属病院, 医員 (60452869)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥3,075,000 (Direct Cost: ¥2,670,000、Indirect Cost: ¥405,000); Fiscal Year 2008: ¥1,755,000 (Direct Cost: ¥1,350,000、Indirect Cost: ¥405,000); Fiscal Year 2007: ¥1,320,000 (Direct Cost: ¥1,320,000)
• Keywords: 歯周ポケット / LPS / ラミニン-5 / MMP-2 / 歯周病原性細菌

Research Abstract

ラット歯肉溝への高濃度LPS滴下による炎症誘導とLPS腹腔内投与による免疫感作による歯周ポケット形成(アタッチメントロス)を伴ったラット歯周炎モデルを確立した。上記モデルを用いて免疫組織学的に歯周ポケット形成過程における経時的なMMP-2とラミニン-5発現の観察を試みている(手技の確立中)。

Research Products

• [Presentation] The systemic immune activation by lipopolysaccharide from Escherichia coli promoted periodontal pocket formation (2008)
  • Author(s): Yasunori Yoshinaga
  • Organizer: The 10th Biennial meeting of the IEIIS
  • Place of Presentation: Edinburgh
  • Year and Date: 2008-08-01
• [Presentation] The systemic immune activation by lipopolysaccharide periodontal pocket formation (2008)
  • Author(s): Yasunori Yoshinaga
  • Organizer: The 10th Biennial meeting of the IEIIS、(1st August)
  • Place of Presentation: Edinburgh