Role of SCGB3A2 in pulmonary fibrosis

• Project/Area Number: 19890175
• Research Category: Grant-in-Aid for Young Scientists (Start-up)
• Allocation Type: Single-year Grants
• Research Field: General physiology
• Research Institution: Yokohama City University
• Principal Investigator: KUROTANI Reiko Yokohama City University, 医学部, 特任助教 (00453043)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥3,095,000 (Direct Cost: ¥2,690,000、Indirect Cost: ¥405,000); Fiscal Year 2008: ¥1,755,000 (Direct Cost: ¥1,350,000、Indirect Cost: ¥405,000); Fiscal Year 2007: ¥1,340,000 (Direct Cost: ¥1,340,000)
• Keywords: SCGB3A2 / 肺線維症 / ブレオマイシン / 肺 / 線維化 / マイクロアレイ

Research Abstract

ブレオマイシン(BLM)誘導性肺線維症モデルを用いて、SCGB3A2が肺線維症を改善することを明らかにし、その作用機序の解明を試みた。マイクロアレイによる遺伝子発現プロファイリングによりSCGB3A2がプロコラーゲン遺伝子群の発現を抑制することを明らかにした。このとき、サイトカインシグナル遺伝子発現が亢進することも明らかになった。

Research Products

• [Journal Article] Drug Delivery System Using Magnetic Materials (2009)
  • Author(s): Shimada C, Kurotani R, Fukumura H, Ono S, Egushi H, Ishikawa Y.
  • Journal Title: 日本病態生理学会雑誌 第18巻第1号(印刷中)
• [Journal Article] Cardiac myosin light chain kinase : a new player in the regulation of myosin light chain in the heart (2008)
  • Author(s): Ishikawa Y, Kurotani R.
  • Journal Title: 2008 Circ Res. 102(5) Pages: 516-518
• [Journal Article] CAATT/enhancer binding proteins alpha and delta interact with NKX2-1 to synergistically activate mouse secretoglobin 3A2 gene expression. (2008)
  • Author(s): Tomita T, Kido T, Kurotani R, Iemura SI, Sterneck E, Natsume T, Vinson C, Kimura S.
  • Journal Title: J Biol Chem 283(37) Pages: 25617-25627
• [Journal Article] Role of Secretoglobin (SCGB) 3A2 in Lung Development (2008)
  • Author(s): Kurotani R, Tomita T, Yang Q, Carlson BA, Chen C, Kimura S.
  • Journal Title: 2008 Am J Respir Crit Care Med. 178(4) Pages: 389-398
• [Journal Article] Type 5 adenylyl cyclase plays a major role in stabilizing heart rate in response to microgravity induced by parabolic flight. (2008)
  • Author(s): Okumura S, Tsunematsu T, Bai Y, Jiao Q, Ono S, Suzuki S, Kurotani R, Sato M, Minamisawa S, Umemura S, Ishikawa Y.
  • Journal Title: J Appl Physiol 105(1) Pages: 173-9
• [Journal Article] Hepatocyte nuclear factor 4alpha in the intestinal epithelial cells protects against inflammatory bowel disease (2008)
  • Author(s): Ahn SH, Shah YM, Inoue J, Morimura K, Kim I, Yim S, Lambert G, Kurotani R, Nagashima K, Gonzalez FJ, Inoue Y.
  • Journal Title: Inflamm Bowel Dis. 14(7) Pages: 908-920
• [Journal Article] CAATT/enhancer binding proteins alpha and delta interact with NKX2-1 to synergistically activate mouse secretoglobin 3A2 gene expression. 2008 (37) : 25617-25627. (2008)
  • Author(s): Tomita T, Kido T, Kurotani R, Iemura SI, Sterneck E, Natsume T, Vinson C, Kimura S.
  • Journal Title: J Biol Chem. 283 Pages: 25617-25627
  • Peer Reviewed
• [Journal Article] Role of Secretoglobin (SCGB) 3A2 in Lung Development. (2008)
  • Author(s): Kurotani R, Tomita T, Yang Q, Carlson BA, Chen C, Kimura S.
  • Journal Title: Am J Respir Crit Care Med 178 Pages: 389-398
  • Peer Reviewed
• [Journal Article] Type 5 adenylyl cyclase plays a major role in stabilizing heart rate in response to microgravity induced by parabolic flight. (2008)
  • Author(s): Okumura S, Tsunematsu T, Bai Y, Jiao Q, Ono S, Suzuki S, Kurotani R, Sato M, Minamisawa S, Umemura S, Ishikawa Y.
  • Journal Title: J Appl Physiol. 105 Pages: 173-179
  • Peer Reviewed
• [Journal Article] Hepatocyte nuclear factor 4alpha in the intestinal epithelial cells protects against inflammatory bowel disease. (2008)
  • Author(s): Ahn SH, Shah YM, InoueJ, Morimura K, Kim I, Yim S, Lambert G, Kurotani R, Nagashima K, Gonzalez FJ, Inoue Y.
  • Journal Title: Inflamm Bowel Dis. 14 Pages: 908-920
  • Peer Reviewed
• [Journal Article] Cardiac myosin light chain kinase : a new player in the regulation of myosin light chain in the heart. (2008)
  • Author(s): Ishikawa Y, Kurotani R.
  • Journal Title: Circ Res. 102 Pages: 516-518
• [Journal Article] Disruption of type 5 adenylyl cyclase enhances desensitization of cyclic adenosine monophosphate signal and increases Akt signal with chronic catecholamine stress (2007)
  • Author(s): Okumura S, Vatner DE, Kurotani R, Bai Y, Gao S, Yuan Z, Iwatsubo K, Ulucan C, Kawabe J, Ghosh K, Vatner SF, Ishikawa Y.
  • Journal Title: Circulation 116(16) Pages: 1776-1783
• [Journal Article] Multiple dose-dependent roles for Sox2 in the patterning and differentiation of anterior foregut endoderm (2007)
  • Author(s): Que J, Okubo T, Goldenring JR, Nam KT, Kurotani R, Morrisey EE, Taranova O, Pevny LH, Hogan BL
  • Journal Title: Development 134(13) Pages: 2521-2531
• [Presentation] 新規磁性化合物を利用した抗癌剤のドラッグデリバリーシステムの開発 (2009)
  • Author(s): 島田千恵美、黒谷玲子、福村英信、小野伸二、江口晴樹、石川義弘
  • Organizer: 第19回日本病態生理学会
  • Place of Presentation: 埼玉
  • Year and Date: 2009-01-24
• [Presentation] SCGB3A2は胎仔肺における新規増殖因子である (2008)
  • Author(s): 黒谷玲子、富田毅、木村芝生子
  • Organizer: 第31回日本分子生物学会, 第81回日本生化学会合同大会
  • Place of Presentation: 神戸
  • Year and Date: 2008-12-10
• [Presentation] 新しいベータアドレナリン受容体シグナル Epac1 とサイトカインシグナルのCross-talk (2008)
  • Author(s): 白水御代, 稲垣萌美, 奥村敏, 黒谷玲子, 白云哲, 金美花, 鈴木さやか, 岩坪耕策, 石川義弘
  • Organizer: 第29回日本循環制御医学会総会
  • Place of Presentation: 横浜
  • Year and Date: 2008-05-10
• [Presentation] 新しいベーダアドレナリン受容体シグナル EpaclとサイトカインシグナルのCross-talk (2008)
  • Author(s): 白水御代, 稲垣萌美, 奥村敏, 黒谷玲子, 白云哲, 金美花, 鈴木さやか, 岩坪耕策, 石川義弘
  • Organizer: 第29回 日本循環制御医学会総会
  • Place of Presentation: 横浜
  • Year and Date: 2008-05-10
• [Presentation] Type 5 Adenylyl Cyclase Plays a Major Role in Regulating Autonomic Response to Microgravity in the Heart (2008)
  • Author(s): Bai Y, Okumura S, Tsunematsu T, Ono S, Suzuki S, Kurotani R, Sato M, Minamisawa S, Ishikawa Y.
  • Organizer: 第72回日本循環器学会
  • Place of Presentation: 福岡
  • Year and Date: 2008-03-28
• [Presentation] 5型アデニル酸シクラーゼが微小重力下における心臓の自律神経に果たす役割 (2008)
  • Author(s): 白云哲、奥村敏、常松尚志、焦其彬、小野伸二、鈴木さやか、黒谷玲子、佐藤元彦、南沢享、石川義弘
  • Organizer: 第85回日本生理学会大会
  • Place of Presentation: 東京
  • Year and Date: 2008-03-27
• [Presentation] 5型アデニル酸シクラーゼの微小重力下での自律神経による心機能制御機構の解析 (2008)
  • Author(s): 白云哲、奥村敏、常松尚志、焦其彬、小野伸二、鈴木さやか、黒谷玲子、佐藤元彦、南沢享、石川義弘
  • Organizer: 第24回宇宙利用シンポジウム
  • Place of Presentation: 東京
  • Year and Date: 2008-01-17
• [Presentation] An involvement of a novel G-protein activator on hypoxia-induced apoptosis of cardiomyocytes and its interaction with connexin 43 American Heart Association (2008)
  • Author(s): Sato M, Honda T, Jiao Q, Kurotani R, Toyota E, Lanier SM and Ishikawa Y
  • Organizer: Scientific Sessions
  • Place of Presentation: New Orleans
• [Presentation] 第一原理解析を利用した創薬溶液中の心臓型アデニル酸シクラーゼ特異的刺激剤の分析 (2008)
  • Author(s): 江口晴樹、黒谷玲子、大津恒治、鈴木さやか、石川義弘
  • Organizer: 第81回日本薬理学会年会
  • Place of Presentation: 横浜
• [Presentation] An involvement of a novel G-protein activator on hypoxia-induced apoptosis of cardiomyocytes and its interaction with connexin 43 (2008)
  • Author(s): Motohiko Sato, Takashi Honda, Qibin Jiao, Reiko Kurotani, Eiji Toyota, Stephen M Lanier, Yoshihiro Ishikawa.
  • Organizer: American Heart Association
  • Place of Presentation: New Orleans
• [Presentation] 新規サーファクタントSCGB3A2は胎仔肺の発生を促進する (2007)
  • Author(s): 黒谷玲子
  • Organizer: 第6回 心血管発生研究会
  • Place of Presentation: 東京
  • Year and Date: 2007-07-06
• [Presentation] SCGB3A2は胎仔肺における新規増殖因子である
  • Author(s): 黒谷 玲子, 富田 毅, 木村 芝生子
  • Organizer: 第31回日本分子生物学会 第81回日本生化学会 合同大会
  • Place of Presentation: 神戸