Effect of Oral Cryotherapy for Preventing Stomatitis, Adverse Chemotherapy

• Project/Area Number: 19890178
• Research Category: Grant-in-Aid for Young Scientists (Start-up)
• Allocation Type: Single-year Grants
• Research Field: Clinical nursing
• Research Institution: Yamanashi Prefectural University
• Principal Investigator: TAKAGISHI Hiromi Yamanashi Prefectural University, 看護学部, 助教 (10453052)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥2,879,000 (Direct Cost: ¥2,480,000、Indirect Cost: ¥399,000); Fiscal Year 2009: ¥234,000 (Direct Cost: ¥180,000、Indirect Cost: ¥54,000); Fiscal Year 2008: ¥1,495,000 (Direct Cost: ¥1,150,000、Indirect Cost: ¥345,000); Fiscal Year 2007: ¥1,150,000 (Direct Cost: ¥1,150,000)
• Keywords: がん / 化学療法 / 口内炎 / クライオセラピー

Research Abstract

Objective : To clarify the effect of oral cryotherapy on the development of stomatitis in the cancer patient who treatment with chemotherapy. Methods : Using a randomized crossover design. Patients (the malignant lymphoma patients during a chemotherapy) were randomized to the cryotherapy group or the control group. Subjects evaluate their QOL utilizing the SF-36 QOL scale. The physician evaluates subject stomatitis both before and 14 days after the initiation of chemotherapy, utilizing the NCI-CTC [National Cancer Institute-Common Toxicity Criteria] Grade Scale. Results : There was no difference in the development of stomatitis between the cryotherapy group and the control group. There was a decrease in QOL between the second and third cycles of chemotherapy as measured by the SF36 QOL scale. Conclusion : The low incidence of stomatitis in subjects during both the cryotherapy group and control group may be due to inadequate consideration of the post-chemotherapy schedule of cryotherapy.

Research Products

• [Presentation] 化学療法を受けている患者の口内炎予防に対するクライオセラピーの効果に関する研究 (2010)
  • Author(s): 高岸弘美
  • Organizer: 第36回日本看護研究学会学術集会
  • Place of Presentation: 岡山市(予定・採択済み)
• [Presentation] 化学療法を受けている患者の口内炎予防対するクライオセラピーの効果に関する研究 (2010)
  • Author(s): 高岸弘美
  • Organizer: 第36回日本看護研究学会 学術集会
  • Place of Presentation: 岡山県岡山市岡山コンベンションセンター
• [Remarks] 独立行政法人日本学術振興会ひらめき☆ときめきサイエンス平成22年度採択:平成22年7月24日・25日実施予定
• [Remarks] 上記関連記事平成22年5月31日山梨日日新聞掲載
• [Remarks] 上記関連HP山梨県立大学HP
  • URL: http://yamanashi-ken.ac.jp/modules/tinyd12/index.php?id=36
• [Remarks] ひらめき☆ときめきサイエンスHP
  • URL: http://www.jsps.go.jp/hirameki/02_jisshi_program.html