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Development of new therapy for osteogenesis using sonoporation and its molecular mechanism

Research Project

Project/Area Number 19890195
Research Category

Grant-in-Aid for Young Scientists (Start-up)

Allocation TypeSingle-year Grants
Research Field Surgical dentistry
Research InstitutionKyushu Dental College

Principal Investigator

IWANAGA Kenjiro  Kyushu Dental College, 歯学部, 助教 (20448484)

Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥3,085,000 (Direct Cost: ¥2,680,000、Indirect Cost: ¥405,000)
Fiscal Year 2008: ¥1,755,000 (Direct Cost: ¥1,350,000、Indirect Cost: ¥405,000)
Fiscal Year 2007: ¥1,330,000 (Direct Cost: ¥1,330,000)
Keywordsソノポレーション / 骨延長 / マイクロバブル / 遺伝子導入 / bFGF
Research Abstract

骨延長術は骨の造成のみならず周囲の骨膜、筋、神経脈管などの軟組織も同時に延長されることから,従来の骨欠損部位に対する自家骨移植術にはない利点を有する.しかしながら骨移植法に比べ治療期間の長期化が大きな欠点とされている.近年,骨延長術の治療期間の短期化を目的とした骨硬化促進の研究がなされている.そこで本研究では顎骨に骨延長術を行い,延長部に対しbFGFを超音波遺伝子法にて骨芽細胞に導入し,創傷治癒促進,骨硬化促進度合を解析したところ,新規骨誘導療法の実現に向け多くの知見を得ることができた.

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (9 results)

All 2009 2008 2007

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (8 results)

  • [Journal Article] Targeted drug delivery system for oral cancer therapy using sonoporation2009

    • Author(s)
      Hironobu Maeda, Kazuhiro Tominaga, Kenjiro Iwanaga, Fuminori Nagao, Manabu Habu, Toshiyuki Tsujisawa, Yuji Seta, Kuniaki Toyoshima, Jin-ichi Fukuda, Tatsuji Nishihara
    • Journal Title

      Journal of Oral Pathology and Medicine (in press)

      Pages: 0-0

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Presentation] ソノポレーション法を用いた遺伝子導入による顎関節炎の次世代治療法の開発2008

    • Author(s)
      永尾史徳,岩永賢二郎,土生学,吉岡泉,福田仁一,冨永和宏
    • Organizer
      第21回日本顎関節学会総会・学術大会
    • Place of Presentation
      大阪
    • Year and Date
      2008-07-27
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] Targeted drug delivery system for cancer therapy using sonoporation2008

    • Author(s)
      Maeda, H., Iwanaga, K., Nagao, F., Tsujisawa, T., Tominaga, K., Fukuda, J., Nishihara, T
    • Organizer
      86st General Session of the IADR
    • Place of Presentation
      Toronto, Canada
    • Year and Date
      2008-07-03
    • Related Report
      2008 Final Research Report
  • [Presentation] Gene transfer of interleukin-1 receptor antagonist into HIG-82 cells2008

    • Author(s)
      Nagao, F., Tujisawa, T., Maeda, H., Iwanaga, K., Habu, M., Yoshioka, I., Tominaga, K., Fukuda, J., Nishihara, T
    • Organizer
      86st General Session of the IADR
    • Place of Presentation
      Toronto, Canada
    • Year and Date
      2008-07-03
    • Related Report
      2008 Final Research Report
  • [Presentation] Targeted drug delivery system for cancer therapy using sonoporation.2008

    • Author(s)
      H, Maeda., K, Iwanaga., et al.
    • Organizer
      86^<st> General Session of the IADR
    • Place of Presentation
      Toronto, Canada
    • Year and Date
      2008-07-03
    • Related Report
      2008 Annual Research Report
  • [Presentation] Gene transfer of interleukin-1 receptor antagonist into HIG-82cells.2008

    • Author(s)
      F, Nagao., K, Iwanaga., et al.
    • Organizer
      86^<st> General Session of the IADR
    • Place of Presentation
      Toronto, Canada
    • Year and Date
      2008-07-03
    • Related Report
      2008 Annual Research Report
  • [Presentation] 超音波を用いたIL-1ra遺伝子導入による滑膜細胞の炎症反応抑制2008

    • Author(s)
      永尾 史徳, 岩永 賢二郎, ら
    • Organizer
      第62回日本口腔科学会学術集会
    • Place of Presentation
      福岡
    • Year and Date
      2008-04-18
    • Related Report
      2007 Annual Research Report
  • [Presentation] 障害者用自動口腔洗浄装置の開発-(第1報)超音波を利用したバイオフィルム除去効果に関する研究2008

    • Author(s)
      西川 健, 岩永 賢二郎, ら
    • Organizer
      第62回日本口腔科学会学術集会
    • Place of Presentation
      福岡
    • Year and Date
      2008-04-18
    • Related Report
      2007 Annual Research Report
  • [Presentation] ソノポレーション法を用いて薬剤および遺伝子を導入したヒト扁平上皮癌に見られた細胞増殖抑制効果について2007

    • Author(s)
      前田 博信, 岩永 賢二郎, ら
    • Organizer
      第49回歯科基礎医学会総会
    • Place of Presentation
      北海道
    • Related Report
      2007 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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