| Project/Area Number |
19890253
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|---|
| Research Category |
Grant-in-Aid for Young Scientists (Start-up)
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| Allocation Type | Single-year Grants |
|---|
| Research Field |
Hygiene
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|---|
| Research Institution | Kawasaki Medical School |
|---|
Principal Investigator |
SHUKO Murakami Kawasaki Medical School, 衛生学, 助教 (50454848)
|
|---|
| Project Period (FY) |
2007 – 2008
|
| Project Status |
Completed (Fiscal Year 2008)
|
| Budget Amount *help |
¥3,075,000 (Direct Cost: ¥2,670,000、Indirect Cost: ¥405,000)
Fiscal Year 2008: ¥1,755,000 (Direct Cost: ¥1,350,000、Indirect Cost: ¥405,000)
Fiscal Year 2007: ¥1,320,000 (Direct Cost: ¥1,320,000)
|
|---|
| Keywords | アスベスト / 細胞増殖 / 転写因子 / アポトーシス / サイトカイン |
|---|
| Research Abstract |
The establishment of in vitro model using cell line for long-term and low-dose exposure model to asbestos on immunocompetent cells and immunological assessment of cases exposed silica, and asbestos were performed. Although increased production of IL-10, which is known as immune-suppressive cytokine, and decreased production of IFNγ, which is immune-activating cytokine, were observed by in vito model, the serum concentration of various cytokines from silicosis and asbestos-exposed patients did not show any apparent difference among these groups except high IL-6 (probably produced by tumor cells) in mesothelioma patients.
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