Role of inflammatory cytokines on lung dysfunction following hemorrhagic shock and its application to forensic diagnosis

• Project/Area Number: 19890263
• Research Category: Grant-in-Aid for Young Scientists (Start-up)
• Allocation Type: Single-year Grants
• Research Field: Legal medicine
• Research Institution: University of Occupational and Environmental Health, Japan
• Principal Investigator: SATO Hiroaki University of Occupational and Environmental Health, Japan, 医学部, 産業医学基礎研究医員 (50441845)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥1,737,000 (Direct Cost: ¥1,560,000、Indirect Cost: ¥177,000); Fiscal Year 2008: ¥767,000 (Direct Cost: ¥590,000、Indirect Cost: ¥177,000); Fiscal Year 2007: ¥970,000 (Direct Cost: ¥970,000)
• Keywords: TNF-α / IL-1 / neutrophil / inflammation / lung dysfunction / IL-1β

Research Abstract

ラットを出血させてショック状態とし,その肺を観察した。すると出血の5時間後には肺障害が生じていて,肺における炎症反応がその原因と考えられた。また,炎症反応の際に増加する好中球という白血球の一種が肺の中で有意に増加していたので,実際の出血性ショック死例の肺を調べたところ他の死因よりも有意に好中球が増加していた。このことから肺での好中球の増加は,出血性ショックの診断マーカーになる可能性が考えられた。

Research Products

• [Journal Article] Marker of death from hemorrhagic shock (2009)
  • Author(s): H Sato, T Kita, T Tanaka, K Kasai, N Tanaka.
  • Journal Title: Legal Medicine 14(in press) Pages: 0-0
  • NAID: 10027262824
  • Peer Reviewed
• [Journal Article] Role of Tumor necrosis factor-α and interleukin-1β on lung dysfunction following hemorrhagic shock in rats. (2008)
  • Author(s): H Sato, K Kasai, T Tanaka, T Kita, N Tanaka
  • Journal Title: Medical Science Monitor 14
  • Peer Reviewed
• [Journal Article] Role of Tumor Necrosis Factor-α and Interleukin-1β on lung dysfunction following hemorrhagic shock in rats (2008)
  • Author(s): 佐藤寛晃
  • Journal Title: Medical Science Monitor 14
  • Peer Reviewed
• [Presentation] Markers of death from hemorrhagic shock. (2008)
  • Author(s): H Sato, T Kita, T Tanaka, K Kasai, N Tanaka
  • Organizer: 7th International Symposium Advances in Legal Medicine
  • Place of Presentation: Osaka
  • Year and Date: 2008-09-03
• [Presentation] Markers of death from hemorrhagic shock (2008)
  • Author(s): 佐藤寛晃
  • Organizer: 7^<th> International Symposium ADVANCES IN LEGAL MEDICINE
  • Place of Presentation: 大阪
  • Year and Date: 2008-09-03
• [Presentation] 出血性ショックにおける多臓器不全の発生メカニズム(第五報)肺障害に関する検討 (2007)
  • Author(s): 佐藤寛晃, 笠井謙多郎, 田中敏子, 北敏郎, 田中宣幸
  • Organizer: 第91次日本法医学会総会
  • Place of Presentation: 秋田
  • Year and Date: 2007-05-18
• [Presentation] 出血性ショックにおける多臓器不全の発生メカニズム(第五報)-肺障害に関する検討- (2007)
  • Author(s): 佐藤 寛晃
  • Organizer: 第91次日本法医学会総会
  • Place of Presentation: 秋田
  • Year and Date: 2007-05-18