Analysis of virulence factors on the inhibition mechanism of cell destruction by Shigella infection

• Project/Area Number: 19890277
• Research Category: Grant-in-Aid for Young Scientists (Start-up)
• Allocation Type: Single-year Grants
• Research Field: Bacteriology (including Mycology)
• Research Institution: National Institute of Infectious Diseases
• Principal Investigator: ISHIHARA Tomoko National Institute of Infectious Diseases, 細菌第一部, 研究員 (30450555)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥3,075,000 (Direct Cost: ¥2,670,000、Indirect Cost: ¥405,000); Fiscal Year 2008: ¥1,755,000 (Direct Cost: ¥1,350,000、Indirect Cost: ¥405,000); Fiscal Year 2007: ¥1,320,000 (Direct Cost: ¥1,320,000)
• Keywords: 感染症 / 細菌 / 微生物

Research Abstract

赤痢菌は腸管上皮細胞に感染し、最終的に感染細胞を含む上皮組織を破壊することによって炎症性下痢を引き起こす。本研究から、赤痢菌は細胞侵入することによって、潜在的にDNAの損傷を引き起こし感染細胞の破壊を昂進する作用を持つ一方、これらの作用を抑制し感染細胞の生存を維持する機構を持つことが示唆された。本成果は赤痢菌の感染メカニズムを理解する上で非常に重要であり、感染制御の基盤的知見となると考えられる。

Research Products

• [Journal Article] Involvement of RNA binding protein hfq in the post-transcriptional regulation of invE gene expression in Shigella sonnei. (2008)
  • Author(s): Mitobe J, Morita-Ishihara T, Ishihama A, Watanabe H.
  • Journal Title: The Journal of Biological Chemistry. 283 Pages: 5738-5747
  • Peer Reviewed
• [Journal Article] Mechanism of cell adhesion and invasion by Type III secretion machinery in Enteropathogenic bacteria. (2008)
  • Author(s): Morita-Ishihara T.
  • Journal Title: Japanese Journal of Lactic acid Bacteria. 19 Pages: 37-45
• [Journal Article] Molecular characterization of Enterohemorrhagic Escherichia coli O157 : H7 isolates dispersed across Japan by pulsed-field gel electrophoresis and multiple-locus variable number tandem repeat analysis. (2008)
  • Author(s): Pei Y, Terajima J, Saito Y, Suzuki R, Takai N, Izumiya H, Morita-Ishihara T, Ohnishi M, Miura M, Iyoda S, Mitobe J, Wang B, Watanabe H.
  • Journal Title: Japanese Journal of Infectious Diseases. 61 Pages: 58-64
  • Peer Reviewed
• [Journal Article] Molecular characterization of Enterohemorrhagic Escherichia coli O157:H7 isolates dispersed across Japan by pulsed-field Rel electrophoresis and multiple-locus variable number tandem repeat analysis (2008)
  • Author(s): Pei Y
  • Journal Title: Japanese Journal of Infectious Diseases 61 Pages: 58-64
  • Peer Reviewed
• [Journal Article] Mechanism of cell adhesion and invasion by Type III secretion machinery in Enteropathogenic bacteria (2008)
  • Author(s): Morita-Ishihara T
  • Journal Title: Japanese Journal of Lactic acid Bacteria 19 Pages: 37-45
• [Journal Article] Involvement of RNA binding protein hfq in the post-transcriptional regulation of invE gene expression in Shigella sonnei (2008)
  • Author(s): Mitobe J
  • Journal Title: The Journal of Biological Chemistry 283 Pages: 5738-47
  • Peer Reviewed
• [Presentation] 赤痢菌による感染上皮細胞の破壊抑制機構についての解析 (2009)
  • Author(s): 石原朋子
  • Organizer: 第82回日本細菌学会総会
  • Place of Presentation: 名古屋
  • Year and Date: 2009-03-12
• [Presentation] Analysis on the inhibition mechanism of cell destruction by Shigella Infection (2008)
  • Author(s): 石原朋子
  • Organizer: Forum of the Network of Research Centers on Infectious Diseases
  • Place of Presentation: ベトナム
  • Year and Date: 2008-10-06
• [Presentation] Analysis on the inhibition mechanism of cell destruction by Shigella infection (2008)
  • Author(s): 石原朋
  • Organizer: Forum of the Network of Research Centers on Infectious Diseases
  • Place of Presentation: ベトナム
  • Year and Date: 2008-10-06
• [Presentation] 赤痢菌感染による細胞破壊抑制機構の解析 (2008)
  • Author(s): 石原朋子
  • Organizer: 第81回日本細菌学会総会
  • Place of Presentation: 京都
  • Year and Date: 2008-03-26