A new strategy in the prophylaxis against testicular dysfunction after cancer chemotherapy aided by high field MRI and MRS

• Project/Area Number: 19890281
• Research Category: Grant-in-Aid for Young Scientists (Start-up)
• Allocation Type: Single-year Grants
• Research Field: Radiation science
• Research Institution: National Cancer Center Research Institute and Research Center for Innovative Oncology, National Cancer Center Hospital East
• Principal Investigator: 山口 雅之 National Cancer Center Research Institute and Research Center for Innovative Oncology, National Cancer Center Hospital East, 研究所及び東病院臨床開発センター・機能診断開発部, 室長 (90450577)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥2,564,000 (Direct Cost: ¥2,240,000、Indirect Cost: ¥324,000); Fiscal Year 2008: ¥1,404,000 (Direct Cost: ¥1,080,000、Indirect Cost: ¥324,000); Fiscal Year 2007: ¥1,160,000 (Direct Cost: ¥1,160,000)
• Keywords: 癌 / 動物 / MRI / MRS / 精巣

Research Abstract

3 Tesla高磁場MRI装置に適合する超高感度信号受信コイルを開発し、直径約200ミクロンのラット精細管の生体内イメージングに成功した。抗癌剤投与後、精巣は縮小、かつ精細管の陰影が不明瞭化し、MRIを使い精巣障害を診断可能であった。この装置と診断基準を用いれば、将来、ヒトでも抗癌剤投与後の障害精巣の診断に役立つ可能性がある。

Research Products

• [Journal Article] Improvement of Radiation-induced Healing Delay by Etanercept-treatment in Rat Arteries. (2009)
  • Author(s): Sugiyama K, Yamaguchi M, Kuroda J, et al. 他4名
  • Journal Title: Cancer Science [Epub ahead of print] Pages: 0-0
  • NAID: 10027193821
  • Peer Reviewed
• [Journal Article] Precise co-registration SPECT and MRI for small animal imaging using a common animal bed with external references : A feasibility study. (2009)
  • Author(s): Yamaguchi M, Fujii H, Inoue K, et al. 他7名
  • Journal Title: Intl Soc Mag Reson Med 17 Pages: 3091-3091
  • Peer Reviewed
• [Journal Article] In vivo visualization of mouse sciatic nerves involved with pancreatic cancer cells using manganese enhanced MR imaging technique. (2009)
  • Author(s): Mieno H, Yamaguchi M, Mitsunaga S, et al. 他8名
  • Journal Title: Proceedings of Intl Soc Mag Reson Med 17 Pages: 2326-2326
  • Peer Reviewed
• [Journal Article] Prolonged signal decay in the ablated area after radiofrequency ablation in the ferucarbotran-administered liver: A basic experimental study for the visualization of ablative margins in a rabbit model. (2009)
  • Author(s): Mori K, Yamaguchi M, Fujii H, et al. 他3名
  • Journal Title: Proceedings of Intl Soc Mag Reson Med 17 Pages: 4047-4047
  • Peer Reviewed
• [Journal Article] Visualization of Seminiferous Tubules in Rat Testes in Normal and Diseased Conditions by High-resolution Magnetic Resonance Imaging (2009)
  • Author(s): Yamaguchi M, Mitsumori F, Watanabe H, Takaya N, Minami M
  • Journal Title: Magnetic Resonance in Medicine (in press)
  • Peer Reviewed
• [Journal Article] Improvement of Radiation-induced Healing Delay by Etanercept-treatment in Rat Arteries (2009)
  • Author(s): Sugiyama K, Yamaguchi M, Kuroda J, et al
  • Journal Title: Cancer Science (in press)
  • NAID: 10027193821
  • Peer Reviewed
• [Journal Article] Precise co-registration SPECT and MRI for small animal imaging using a common animal bed with external references : A feasibility study (2009)
  • Author(s): Yamaguchi M, Fujii H, Inoue K, et al
  • Journal Title: Proceedings International Society for Magnetic Resonance in Medicine 17 Pages: 3091-3091
  • Peer Reviewed
• [Journal Article] In vivo visualization of mouse sciatic nerves involved with pancreatic cancer cells using manganese enhanced MR imaging technique (2009)
  • Author(s): Mieno H, Yamaguchi M, Mitsunaga S, et al.
  • Journal Title: Proceedings International Society for Magnetic Resonance in Medicine 17 Pages: 2326-2326
  • Peer Reviewed
• [Journal Article] Prolonged signal decay in the ablated area after radiofrequency ablation in the ferucarbotran-administered liver : A basic experimental study for the visualization of ablative margins in a rabbit model (2009)
  • Author(s): Mori K, Yamaguchi M, Fujii H, Nakagami R, Furuta T, Minami M
  • Journal Title: Proceedings International Society for Magnetic Resonance in Medicine 17 Pages: 4047-4047
  • Peer Reviewed
• [Journal Article] Visualization of Seminiferous Tubules in Rat Testes in Normal and Diseased Conditions by High-resolution Magnetic Resonance Imaging. (2008)
  • Author(s): Yamaguchi M, Mitsumori F, Watanabe H, et al. 他2名
  • Journal Title: Magnetic Resonance in Medicine in press Pages: 0-0
  • Peer Reviewed
• [Journal Article] Validation of diffusion tensor imaging and tractography of the human peripheral nerve using small-diameter ex vivo phantoms. (2008)
  • Author(s): Kunimatsu A, Yamaguchi M, Okamoto Y, et al. 他5名
  • Journal Title: Proceedings of Intl Soc Mag Reson Med 16 Pages: 3304-3304
  • Peer Reviewed
• [Journal Article] バイオマーカー研究の現状と展開 機能診断 (2007)
  • Author(s): 藤井博史、梅田泉、山口雅之
  • Journal Title: がん分子標的治療 5(4) Pages: 268-274
• [Journal Article] ^1H MRS assessment of spermatogenic activity in experimentally injured rat testes. (2007)
  • Author(s): Yamaguchi M, Mitsumori F, Watanabe H, et al. 他2名
  • Journal Title: Proceedings of Intl Soc Mag Reson Med 15 Pages: 2738-2738
  • Peer Reviewed
• [Journal Article] 1H MRS assessment of spermatogenic activity in experimentally injured rat testes. (2007)
  • Author(s): Yamaguchi M, et. al.
  • Journal Title: Proceedings International Society for Magetic Resonance in Medicine 15 Pages: 2738-2738
  • Peer Reviewed
• [Journal Article] バイオマーカー研究の現状と展開:機能画像診断 (2007)
  • Author(s): 藤井 博史、梅田 泉、山口 雅之
  • Journal Title: がん分子標的療法 5 Pages: 268-274
• [Presentation] 腫瘍モデルマウスの拡散強調MRイメージング : マルチショットエコープラナーイメージングの有用性 (2008)
  • Author(s): 山口雅之、梅田泉、藤井博史
  • Organizer: 第67回日本癌学会学術総会
  • Place of Presentation: 名古屋市
  • Year and Date: 2008-10-29
• [Presentation] ヒト膵がん神経浸潤モデルを用いた、膵がん神経浸潤のin vivo MRイメージング (2008)
  • Author(s): 光永修一、山口雅之、落合敦志、他
  • Organizer: 第67回日本癌学会学術総会
  • Place of Presentation: 名古屋市
  • Year and Date: 2008-10-29
• [Presentation] 腫瘍モデルマウスの拡散強調MRイメージング:マルチショットエコープラナーイメージングの有用性 (2008)
  • Author(s): 山口雅之, 梅田泉, 藤井博史
  • Organizer: 第67回日本癌学会学術総会
  • Place of Presentation: 名古屋市
  • Year and Date: 2008-10-29
• [Presentation] ヒト膵がん神経浸潤モデルを用いた、膵がん神経浸潤の in vivo MRイメージング (2008)
  • Author(s): 光永修一, 山口雅之, 落合敦志, 藤井博史
  • Organizer: 第67回日本癌学会学術総会
  • Place of Presentation: 名古屋市
  • Year and Date: 2008-10-29
• [Presentation] 人用3TMRI上での動物マイクロイメージングデバイス : 信号不均一性の検討 (2008)
  • Author(s): 中神龍太朗、山口雅之、平山章、他
  • Organizer: 第36回日本磁気共鳴医学会
  • Place of Presentation: 旭川市
  • Year and Date: 2008-09-12
• [Presentation] 人用3T MRI上での動物マイクロイメージングデバイス:信号不均一性の検討 (2008)
  • Author(s): 中神龍太朗, 山口雅之, 平山章, 他
  • Organizer: 第36回日本磁気共鳴医学会
  • Place of Presentation: 旭川市
  • Year and Date: 2008-09-12
• [Presentation] 3テスラ全身用装置によるラット精細管の高精細MRI観測 (2008)
  • Author(s): 山口雅之、奈部谷章、野崎敦、他
  • Organizer: 第36回日本磁気共鳴医学会
  • Place of Presentation: 旭川市
  • Year and Date: 2008-09-11
• [Presentation] 小動物用SPECTに融合させるべきはMRIかCTか? (2008)
  • Author(s): 山口雅之、井上一雅、梅田泉、他
  • Organizer: 第36回日本磁気共鳴医学会
  • Place of Presentation: 旭川市
  • Year and Date: 2008-09-11
• [Presentation] whole body MRI臨床装置を用いた微小検体マイクロイメージング (2008)
  • Author(s): 山口雅之、奈部谷章、野崎敦、他 高磁場
  • Organizer: 第67回日本医学放射線学会総会
  • Place of Presentation: 横浜市
  • Year and Date: 2008-04-05
• [Presentation] 高磁場 whole body MRI臨床装置を用いた微小検体マイクロイメージング (2008)
  • Author(s): 山口雅之, 奈部谷章, 野崎敦, 梅田泉, 井上一雅, 藤井博史
  • Organizer: 第67回日本医学放射線学会総会
  • Place of Presentation: 横浜市
  • Year and Date: 2008-04-05
• [Presentation] MR microscopyによる精巣機能評価(招待講演) (2007)
  • Author(s): 山口雅之, 三森文行
  • Organizer: 第35回日本磁気共鳴医学会大会
  • Place of Presentation: 神戸市
  • Year and Date: 2007-09-29
• [Presentation] MR microscopyによる精巣機能評価 (2007)
  • Author(s): 山口 雅之
  • Organizer: 第35回日本磁気共鳴医学会
  • Place of Presentation: 神戸ポートピアホテル