| Project/Area Number |
19F19408
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| Research Category |
Grant-in-Aid for JSPS Fellows
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| Allocation Type | Single-year Grants |
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| Section | 外国 |
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| Review Section |
Basic Section 59040:Nutrition science and health science-related
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| Research Institution | Waseda University |
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Principal Investigator |
秋本 崇之 早稲田大学, スポーツ科学学術院, 教授 (00323460)
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| Co-Investigator(Kenkyū-buntansha) |
LEE MINJUNG 早稲田大学, スポーツ科学学術院, 外国人特別研究員
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| Project Period (FY) |
2019-11-08 – 2022-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥2,300,000 (Direct Cost: ¥2,300,000)
Fiscal Year 2020: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 2019: ¥1,000,000 (Direct Cost: ¥1,000,000)
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| Keywords | progeria / non-cording RNAs / activity / development / exercise |
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| Outline of Research at the Start |
Our group has focused on microRNAs (miRNAs) to investigate their roles in skeletal muscle biology. We found a mouse lacking specific miRNAs (KO mice) showed accelerated aging phenotype. The KO mice showed low physical activity, growth retardation, hair loss, hair graying and kyphosis earlier than WT mice. The aging phenotypes are progressive and result in short lifespan in the KO mice.
In the present study, we define the function of the miRNAs on aging.
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| Outline of Annual Research Achievements |
MicroRNA (miRNA) is a small non-coding RNA which represses its target genes at post-transcriptional level. In previous studies, the host researcher established genetically modified mice of several miRNAs which are involved in exercise-induced skeletal muscle adaptation. Coincidentally, we found that certain modification of miRNAs caused accelerated aging. To clarify the aging factor(s), first we determined the aging phenotypes of the GM mice during the fellowship tenure.
The average lifespan of GM mice were significantly shorter than those for males and females for WT. The median survival time was also significantly shorter in GM mice than in WT mice. Frailty index of the GM mice was significantly higher than that of WT mice. Collectively, these results suggested that the aging process is accelerated in the GM mice and it eventually shortened the lifespan of the mice.
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| Research Progress Status |
翌年度、交付申請を辞退するため、記入しない。
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| Strategy for Future Research Activity |
翌年度、交付申請を辞退するため、記入しない。
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