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On the Role of Mechanical Interactions in Cellular Systems

Research Project

Project/Area Number 19F19705
Research Category

Grant-in-Aid for JSPS Fellows

Allocation TypeSingle-year Grants
Section外国
Review Section Basic Section 13040:Biophysics, chemical physics and soft matter physics-related
Research InstitutionOkinawa Institute of Science and Technology Graduate University

Principal Investigator

フリード エリオット  沖縄科学技術大学院大学, 力学と材料科学ユニット, 教授 (70735761)

Co-Investigator(Kenkyū-buntansha) KWIECINSKI JAMES  沖縄科学技術大学院大学, 数理力学と材料科学ユニット, 外国人特別研究員
Project Period (FY) 2019-10-11 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥1,400,000 (Direct Cost: ¥1,400,000)
Fiscal Year 2021: ¥300,000 (Direct Cost: ¥300,000)
Fiscal Year 2020: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 2019: ¥400,000 (Direct Cost: ¥400,000)
KeywordsMathematical model / cellular systems / protein interaction / immune system / macromolecules / B-cell
Outline of Research at the Start

The goal of this research is to build a realistic mathematical model of membrane-mediated interactions between proteins and macromolecules, focusing on how they affect the shape of lipid bilayers and on the prelude to antigen extraction by white-blood cells. The research will increase the understanding of key cellular processes. By determining the basic interaction laws between proteins and macromolecules and the process by which they assemble and aggregate, the computational cost of large-scale simulations will be significantly reduced, leading to the ability to model more complex systems.

Outline of Annual Research Achievements

Dr. Kwiecinski was preparing a sole author paper on a mathematical model describing the relaxation of rotational behavior of viscoelastic solids entitled "Relaxation of Viscoelastic Tumblers with Application to 1I/2017 (`Oumuamua) and 4179 Toutatis" with plans to submit this to the Monthly Notices for the Royal Astronomical Society.

Research Progress Status

令和3年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

令和3年度が最終年度であるため、記入しない。

Report

(3 results)
  • 2021 Annual Research Report
  • 2020 Annual Research Report
  • 2019 Annual Research Report
  • Research Products

    (2 results)

All 2020

All Journal Article (2 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 2 results)

  • [Journal Article] Interactions of anisotropic inclusions on a fluid membrane2020

    • Author(s)
      Kwiecinski, J. A., Goriely, A., and Chapman S. J.
    • Journal Title

      SIAM Journal on Applied Mathematics

      Volume: 80 Issue: 6 Pages: 2448-2471

    • DOI

      10.1137/20m1332694

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Relaxation of viscoelastic tumblers with application to 1I/2017 U1 ('Oumuamua) and 4179 Toutatis2020

    • Author(s)
      Kwiecinski, J. A.
    • Journal Title

      Monthly Notices of the Royal Astronomical Society

      Volume: 497 Issue: 1 Pages: 19-36

    • DOI

      10.1093/mnras/staa1933

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research

URL: 

Published: 2019-10-15   Modified: 2024-03-26  

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